Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic
Identifieur interne : 000D59 ( Pmc/Checkpoint ); précédent : 000D58; suivant : 000D60Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic
Auteurs : Rafi Ahmed ; Michael B A. Oldstone [États-Unis] ; Peter Palese [États-Unis]Source :
- Nature Immunology [ 1529-2908 ] ; 2007.
Abstract
The influenza pandemic of 1918 killed nearly 50 million people worldwide and was characterized by an atypical W-shaped mortality curve, where adults between the ages of 30–60 years fared better than younger adults aged 18–30 years. In this review, we will discuss why this influenza virus strain was so virulent and how immunological memory to the 1918 virus may have shaped the W mortality curve. We will end on the topic of the 'honeymoon' period of infectious diseases—the clinically documented period between the ages of 4–13 years during which children demonstrate less morbidity and/or mortality to infectious diseases, in general, compared with young adults.
Url:
DOI: 10.1038/ni1530
PubMed: 17952044
PubMed Central: 7097533
Affiliations:
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Nat Immunol</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Immunol</journal-id><journal-title-group><journal-title>Nature Immunology</journal-title></journal-title-group><issn pub-type="ppub">1529-2908</issn><issn pub-type="epub">1529-2916</issn><publisher><publisher-name>Nature Publishing Group US</publisher-name><publisher-loc>New York</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17952044</article-id><article-id pub-id-type="pmc">7097533</article-id><article-id pub-id-type="publisher-id">BFni1530</article-id><article-id pub-id-type="doi">10.1038/ni1530</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Ahmed</surname><given-names>Rafi</given-names></name><address><email>ra@microbio.emory.edu</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Oldstone</surname><given-names>Michael B A</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Palese</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.189967.8</institution-id><institution-id institution-id-type="ISNI">0000 0001 0941 6502</institution-id><institution>Emory Vaccine Center and Department of Microbiology and Immunology,</institution><institution>Emory University School of Medicine,</institution></institution-wrap>Atlanta, 30322 Georgia USA</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.214007.0</institution-id><institution-id institution-id-type="ISNI">0000000122199231</institution-id><institution>Molecular and Integrative Neurosciences Department,</institution><institution>Viral-Immunobiology Laboratory, The Scripps Research Institute,</institution></institution-wrap>10550 N. Torrey Pines Road, La Jolla, 92037 California USA</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.59734.3c</institution-id><institution-id institution-id-type="ISNI">0000 0001 0670 2351</institution-id><institution>Departments of Microbiology and Medicine,</institution><institution>Mount Sinai School of Medicine,</institution></institution-wrap>1 Gustave L. Levy Place, New York, 10029 New York USA</aff></contrib-group><pub-date pub-type="epub"><day>19</day><month>10</month><year>2007</year></pub-date><pub-date pub-type="ppub"><year>2007</year></pub-date><volume>8</volume><issue>11</issue><fpage>1188</fpage><lpage>1193</lpage><permissions><copyright-statement>© Nature Publishing Group 2007</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p id="Par1">The influenza pandemic of 1918 killed nearly 50 million people worldwide and was characterized by an atypical W-shaped mortality curve, where adults between the ages of 30–60 years fared better than younger adults aged 18–30 years. In this review, we will discuss why this influenza virus strain was so virulent and how immunological memory to the 1918 virus may have shaped the W mortality curve. We will end on the topic of the 'honeymoon' period of infectious diseases—the clinically documented period between the ages of 4–13 years during which children demonstrate less morbidity and/or mortality to infectious diseases, in general, compared with young adults.</p></abstract><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s), under exclusive licence to Springer Nature America, Inc. 2007</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>État de New York</li></region><settlement><li>New York</li></settlement></list><tree><noCountry><name sortKey="Ahmed, Rafi" sort="Ahmed, Rafi" uniqKey="Ahmed R" first="Rafi" last="Ahmed">Rafi Ahmed</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Oldstone, Michael B A" sort="Oldstone, Michael B A" uniqKey="Oldstone M" first="Michael B A" last="Oldstone">Michael B A. Oldstone</name></region><name sortKey="Palese, Peter" sort="Palese, Peter" uniqKey="Palese P" first="Peter" last="Palese">Peter Palese</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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