Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic
Identifieur interne : 000593 ( Ncbi/Checkpoint ); précédent : 000592; suivant : 000594Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic
Auteurs : Rafi Ahmed ; Michael B A. Oldstone [États-Unis] ; Peter Palese [États-Unis]Source :
- Nature Immunology [ 1529-2908 ] ; 2007.
Descripteurs français
- KwdFr :
- MESH :
- histoire : Flambées de maladies.
- immunologie : Grippe humaine, Susceptibilité à une maladie.
- mortalité : Grippe humaine.
- Adolescent, Adulte, Enfant, Facteurs de l'âge, Histoire du 20ème siècle, Humains, Mémoire immunologique.
English descriptors
- KwdEn :
- MESH :
- history : Disease Outbreaks.
- immunology : Disease Susceptibility, Influenza, Human.
- mortality : Influenza, Human.
- Adolescent, Adult, Age Factors, Child, History, 20th Century, Humans, Immunologic Memory.
Abstract
The influenza pandemic of 1918 killed nearly 50 million people worldwide and was characterized by an atypical W-shaped mortality curve, where adults between the ages of 30–60 years fared better than younger adults aged 18–30 years. In this review, we will discuss why this influenza virus strain was so virulent and how immunological memory to the 1918 virus may have shaped the W mortality curve. We will end on the topic of the 'honeymoon' period of infectious diseases—the clinically documented period between the ages of 4–13 years during which children demonstrate less morbidity and/or mortality to infectious diseases, in general, compared with young adults.
Url:
DOI: 10.1038/ni1530
PubMed: 17952044
PubMed Central: 7097533
Affiliations:
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PMC:7097533Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="Par1">The influenza pandemic of 1918 killed nearly 50 million people worldwide and was characterized by an atypical W-shaped mortality curve, where adults between the ages of 30–60 years fared better than younger adults aged 18–30 years. In this review, we will discuss why this influenza virus strain was so virulent and how immunological memory to the 1918 virus may have shaped the W mortality curve. We will end on the topic of the 'honeymoon' period of infectious diseases—the clinically documented period between the ages of 4–13 years during which children demonstrate less morbidity and/or mortality to infectious diseases, in general, compared with young adults.</p>
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