Antigenic Fingerprinting of H5N1 Avian Influenza Using Convalescent Sera and Monoclonal Antibodies Reveals Potential Vaccine and Diagnostic Targets
Identifieur interne : 003E42 ( Main/Exploration ); précédent : 003E41; suivant : 003E43Antigenic Fingerprinting of H5N1 Avian Influenza Using Convalescent Sera and Monoclonal Antibodies Reveals Potential Vaccine and Diagnostic Targets
Auteurs : Surender Khurana [États-Unis] ; Amorsolo L. Suguitan [États-Unis] ; Yonaira Rivera [États-Unis] ; Cameron P. Simmons [Viêt Nam] ; Antonio Lanzavecchia [Suisse] ; Federica Sallusto [Suisse] ; Jody Manischewitz [États-Unis] ; Lisa R. King [États-Unis] ; Kanta Subbarao [États-Unis] ; Hana Golding [États-Unis]Source :
- PLoS Medicine [ 1549-1277 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux, Antigènes viraux (immunologie), Banque génomique, Cartographie épitopique, Convalescence, Facteurs de virulence, Grippe chez les oiseaux (immunologie), Grippe chez les oiseaux (virologie), Humains, Oiseaux, Protéines de la matrice virale (immunologie), Protéines virales (antagonistes et inhibiteurs), Protéines virales (immunologie), Sialidase (immunologie), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (pathogénicité), Vaccins antigrippaux (immunologie), Vietnam, Épitopes (sang).
- MESH :
- antagonistes et inhibiteurs : Protéines virales.
- immunologie : Antigènes viraux, Grippe chez les oiseaux, Protéines de la matrice virale, Protéines virales, Sialidase, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux.
- pathogénicité : Sous-type H5N1 du virus de la grippe A.
- sang : Épitopes.
- virologie : Grippe chez les oiseaux.
- Animaux, Anticorps monoclonaux, Banque génomique, Cartographie épitopique, Convalescence, Facteurs de virulence, Humains, Oiseaux, Vietnam.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal, Antigens, Viral (immunology), Birds, Convalescence, Epitope Mapping, Epitopes (blood), Genomic Library, Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H3N2 Subtype (immunology), Influenza A Virus, H5N1 Subtype (immunology), Influenza A Virus, H5N1 Subtype (pathogenicity), Influenza Vaccines (immunology), Influenza in Birds (immunology), Influenza in Birds (virology), Neuraminidase (immunology), Vietnam, Viral Matrix Proteins (immunology), Viral Proteins (antagonists & inhibitors), Viral Proteins (immunology), Virulence Factors.
- MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , blood : Epitopes.
- chemical , immunology : Antigens, Viral, Influenza Vaccines, Neuraminidase, Viral Matrix Proteins, Viral Proteins.
- chemical : Antibodies, Monoclonal, Virulence Factors.
- geographic : Vietnam.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A Virus, H5N1 Subtype, Influenza in Birds.
- pathogenicity : Influenza A Virus, H5N1 Subtype.
- virology : Influenza in Birds.
- Animals, Birds, Convalescence, Epitope Mapping, Genomic Library, Humans.
Abstract
Using whole-genome-fragment phage display libraries, Hana Golding and colleagues identify the viral epitopes recognized by serum antibodies in humans who have recovered from infection with H5N1 avian influenza.
Url:
DOI: 10.1371/journal.pmed.1000049
PubMed: 19381279
PubMed Central: 2661249
Affiliations:
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Le document en format XML
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Suguitan</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Rivera, Yonaira" sort="Rivera, Yonaira" uniqKey="Rivera Y" first="Yonaira" last="Rivera">Yonaira Rivera</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P." last="Simmons">Cameron P. 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King</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Golding, Hana" sort="Golding, Hana" uniqKey="Golding H" first="Hana" last="Golding">Hana Golding</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Medicine</title><idno type="ISSN">1549-1277</idno><idno type="eISSN">1549-1676</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal</term><term>Antigens, Viral (immunology)</term><term>Birds</term><term>Convalescence</term><term>Epitope Mapping</term><term>Epitopes (blood)</term><term>Genomic Library</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A Virus, H3N2 Subtype (immunology)</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Influenza A Virus, H5N1 Subtype (pathogenicity)</term><term>Influenza Vaccines (immunology)</term><term>Influenza in Birds (immunology)</term><term>Influenza in Birds (virology)</term><term>Neuraminidase (immunology)</term><term>Vietnam</term><term>Viral Matrix Proteins (immunology)</term><term>Viral Proteins (antagonists & inhibitors)</term><term>Viral Proteins (immunology)</term><term>Virulence Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux</term><term>Antigènes viraux (immunologie)</term><term>Banque génomique</term><term>Cartographie épitopique</term><term>Convalescence</term><term>Facteurs de virulence</term><term>Grippe chez les oiseaux (immunologie)</term><term>Grippe chez les oiseaux (virologie)</term><term>Humains</term><term>Oiseaux</term><term>Protéines de la matrice virale (immunologie)</term><term>Protéines virales (antagonistes et inhibiteurs)</term><term>Protéines virales (immunologie)</term><term>Sialidase (immunologie)</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H3N2 du virus de la grippe A (immunologie)</term><term>Sous-type H5N1 du virus de la grippe A (immunologie)</term><term>Sous-type H5N1 du virus de la grippe A (pathogénicité)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vietnam</term><term>Épitopes (sang)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Epitopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term><term>Influenza Vaccines</term><term>Neuraminidase</term><term>Viral Matrix Proteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Virulence Factors</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Vietnam</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term><term>Grippe chez les oiseaux</term><term>Protéines de la matrice virale</term><term>Protéines virales</term><term>Sialidase</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H5N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Birds</term><term>Convalescence</term><term>Epitope Mapping</term><term>Genomic Library</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux</term><term>Banque génomique</term><term>Cartographie épitopique</term><term>Convalescence</term><term>Facteurs de virulence</term><term>Humains</term><term>Oiseaux</term><term>Vietnam</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Using whole-genome-fragment phage display libraries, Hana Golding and colleagues identify the viral epitopes recognized by serum antibodies in humans who have recovered from infection with H5N1 avian influenza.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K 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uniqKey="Horton M">MS Horton</name></author><author><name sortKey="Fan, J" uniqKey="Fan J">J Fan</name></author><author><name sortKey="Citron, Mp" uniqKey="Citron M">MP Citron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Black, Ra" uniqKey="Black R">RA Black</name></author><author><name sortKey="Rota, Pa" uniqKey="Rota P">PA Rota</name></author><author><name sortKey="Gorodkova, N" uniqKey="Gorodkova N">N Gorodkova</name></author><author><name sortKey="Klenk, Hd" uniqKey="Klenk H">HD Klenk</name></author><author><name sortKey="Kendal, Ap" uniqKey="Kendal A">AP Kendal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zamarin, D" uniqKey="Zamarin D">D Zamarin</name></author><author><name sortKey="Ortigoza, Mb" uniqKey="Ortigoza M">MB Ortigoza</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Suisse</li><li>Viêt Nam</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Khurana, Surender" sort="Khurana, Surender" uniqKey="Khurana S" first="Surender" last="Khurana">Surender Khurana</name></region><name sortKey="Golding, Hana" sort="Golding, Hana" uniqKey="Golding H" first="Hana" last="Golding">Hana Golding</name><name sortKey="King, Lisa R" sort="King, Lisa R" uniqKey="King L" first="Lisa R." last="King">Lisa R. King</name><name sortKey="Manischewitz, Jody" sort="Manischewitz, Jody" uniqKey="Manischewitz J" first="Jody" last="Manischewitz">Jody Manischewitz</name><name sortKey="Rivera, Yonaira" sort="Rivera, Yonaira" uniqKey="Rivera Y" first="Yonaira" last="Rivera">Yonaira Rivera</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Suguitan, Amorsolo L" sort="Suguitan, Amorsolo L" uniqKey="Suguitan A" first="Amorsolo L." last="Suguitan">Amorsolo L. Suguitan</name></country><country name="Viêt Nam"><noRegion><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P." last="Simmons">Cameron P. Simmons</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name></noRegion><name sortKey="Sallusto, Federica" sort="Sallusto, Federica" uniqKey="Sallusto F" first="Federica" last="Sallusto">Federica Sallusto</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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