Antigenic fingerprinting of H5N1 avian influenza using convalescent sera and monoclonal antibodies reveals potential vaccine and diagnostic targets.
Identifieur interne : 001676 ( PubMed/Checkpoint ); précédent : 001675; suivant : 001677Antigenic fingerprinting of H5N1 avian influenza using convalescent sera and monoclonal antibodies reveals potential vaccine and diagnostic targets.
Auteurs : Surender Khurana [États-Unis] ; Amorsolo L. Suguitan ; Yonaira Rivera ; Cameron P. Simmons ; Antonio Lanzavecchia ; Federica Sallusto ; Jody Manischewitz ; Lisa R. King ; Kanta Subbarao ; Hana GoldingSource :
- PLoS medicine [ 1549-1676 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux, Antigènes viraux (immunologie), Banque génomique, Cartographie épitopique, Convalescence, Facteurs de virulence, Grippe chez les oiseaux (immunologie), Grippe chez les oiseaux (virologie), Humains, Oiseaux, Protéines de la matrice virale (immunologie), Protéines virales (antagonistes et inhibiteurs), Protéines virales (immunologie), Sialidase (immunologie), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (pathogénicité), Vaccins antigrippaux (immunologie), Vietnam, Épitopes (sang).
- MESH :
- antagonistes et inhibiteurs : Protéines virales.
- immunologie : Antigènes viraux, Grippe chez les oiseaux, Protéines de la matrice virale, Protéines virales, Sialidase, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux.
- pathogénicité : Sous-type H5N1 du virus de la grippe A.
- sang : Épitopes.
- virologie : Grippe chez les oiseaux.
- Animaux, Anticorps monoclonaux, Banque génomique, Cartographie épitopique, Convalescence, Facteurs de virulence, Humains, Oiseaux, Vietnam.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal, Antigens, Viral (immunology), Birds, Convalescence, Epitope Mapping, Epitopes (blood), Genomic Library, Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H3N2 Subtype (immunology), Influenza A Virus, H5N1 Subtype (immunology), Influenza A Virus, H5N1 Subtype (pathogenicity), Influenza Vaccines (immunology), Influenza in Birds (immunology), Influenza in Birds (virology), Neuraminidase (immunology), Vietnam, Viral Matrix Proteins (immunology), Viral Proteins (antagonists & inhibitors), Viral Proteins (immunology), Virulence Factors.
- MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , blood : Epitopes.
- chemical , immunology : Antigens, Viral, Influenza Vaccines, Neuraminidase, Viral Matrix Proteins, Viral Proteins.
- chemical : Antibodies, Monoclonal, Virulence Factors.
- geographic : Vietnam.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A Virus, H5N1 Subtype, Influenza in Birds.
- pathogenicity : Influenza A Virus, H5N1 Subtype.
- virology : Influenza in Birds.
- Animals, Birds, Convalescence, Epitope Mapping, Genomic Library, Humans.
Abstract
Transmission of highly pathogenic avian H5N1 viruses from poultry to humans have raised fears of an impending influenza pandemic. Concerted efforts are underway to prepare effective vaccines and therapies including polyclonal or monoclonal antibodies against H5N1. Current efforts are hampered by the paucity of information on protective immune responses against avian influenza. Characterizing the B cell responses in convalescent individuals could help in the design of future vaccines and therapeutics.
DOI: 10.1371/journal.pmed.1000049
PubMed: 19381279
Affiliations:
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pubmed:19381279Le document en format XML
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(immunologie)</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H3N2 du virus de la grippe A (immunologie)</term><term>Sous-type H5N1 du virus de la grippe A (immunologie)</term><term>Sous-type H5N1 du virus de la grippe A (pathogénicité)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vietnam</term><term>Épitopes (sang)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Epitopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term><term>Influenza Vaccines</term><term>Neuraminidase</term><term>Viral Matrix Proteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Virulence Factors</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Vietnam</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term><term>Grippe chez les oiseaux</term><term>Protéines de la matrice virale</term><term>Protéines virales</term><term>Sialidase</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H5N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Birds</term><term>Convalescence</term><term>Epitope Mapping</term><term>Genomic Library</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux</term><term>Banque génomique</term><term>Cartographie épitopique</term><term>Convalescence</term><term>Facteurs de virulence</term><term>Humains</term><term>Oiseaux</term><term>Vietnam</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Transmission of highly pathogenic avian H5N1 viruses from poultry to humans have raised fears of an impending influenza pandemic. Concerted efforts are underway to prepare effective vaccines and therapies including polyclonal or monoclonal antibodies against H5N1. Current efforts are hampered by the paucity of information on protective immune responses against avian influenza. Characterizing the B cell responses in convalescent individuals could help in the design of future vaccines and therapeutics.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19381279</PMID><DateCompleted><Year>2009</Year><Month>06</Month><Day>09</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1549-1676</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>4</Issue><PubDate><Year>2009</Year><Month>Apr</Month><Day>21</Day></PubDate></JournalIssue><Title>PLoS medicine</Title><ISOAbbreviation>PLoS Med.</ISOAbbreviation></Journal><ArticleTitle>Antigenic fingerprinting of H5N1 avian influenza using convalescent sera and monoclonal antibodies reveals potential vaccine and diagnostic targets.</ArticleTitle><Pagination><MedlinePgn>e1000049</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pmed.1000049</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Transmission of highly pathogenic avian H5N1 viruses from poultry to humans have raised fears of an impending influenza pandemic. Concerted efforts are underway to prepare effective vaccines and therapies including polyclonal or monoclonal antibodies against H5N1. Current efforts are hampered by the paucity of information on protective immune responses against avian influenza. Characterizing the B cell responses in convalescent individuals could help in the design of future vaccines and therapeutics.</AbstractText><AbstractText Label="METHODS AND FINDINGS" NlmCategory="RESULTS">To address this need, we generated whole-genome-fragment phage display libraries (GFPDL) expressing fragments of 15-350 amino acids covering all the proteins of A/Vietnam/1203/2004 (H5N1). These GFPDL were used to analyze neutralizing human monoclonal antibodies and sera of five individuals who had recovered from H5N1 infection. This approach led to the mapping of two broadly neutralizing human monoclonal antibodies with conformation-dependent epitopes. In H5N1 convalescent sera, we have identified several potentially protective H5N1-specific human antibody epitopes in H5 HA[(-10)-223], neuraminidase catalytic site, and M2 ectodomain. In addition, for the first time to our knowledge in humans, we identified strong reactivity against PB1-F2, a putative virulence factor, following H5N1 infection. Importantly, novel epitopes were identified, which were recognized by H5N1-convalescent sera but did not react with sera from control individuals (H5N1 naïve, H1N1 or H3N2 seropositive).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This is the first study, to our knowledge, describing the complete antibody repertoire following H5N1 infection. Collectively, these data will contribute to rational vaccine design and new H5N1-specific serodiagnostic surveillance tools.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Khurana</LastName><ForeName>Surender</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suguitan</LastName><ForeName>Amorsolo L</ForeName><Initials>AL</Initials><Suffix>Jr</Suffix></Author><Author ValidYN="Y"><LastName>Rivera</LastName><ForeName>Yonaira</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Simmons</LastName><ForeName>Cameron P</ForeName><Initials>CP</Initials></Author><Author ValidYN="Y"><LastName>Lanzavecchia</LastName><ForeName>Antonio</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Sallusto</LastName><ForeName>Federica</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Manischewitz</LastName><ForeName>Jody</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>King</LastName><ForeName>Lisa R</ForeName><Initials>LR</Initials></Author><Author ValidYN="Y"><LastName>Subbarao</LastName><ForeName>Kanta</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Golding</LastName><ForeName>Hana</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>079864</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>04</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS Med</MedlineTA><NlmUniqueID>101231360</NlmUniqueID><ISSNLinking>1549-1277</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000956">Antigens, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000939">Epitopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C488937">M2 protein, Influenza A virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C442816">PB1-F2 protein, Influenza A virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014763">Viral Matrix Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D037521">Virulence Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.18</RegistryNumber><NameOfSubstance UI="D009439">Neuraminidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>PLoS Med. 2009 Apr 21;6(4):e1000064</RefSource><PMID Version="1">19381281</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" 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sortKey="Golding, Hana" sort="Golding, Hana" uniqKey="Golding H" first="Hana" last="Golding">Hana Golding</name><name sortKey="King, Lisa R" sort="King, Lisa R" uniqKey="King L" first="Lisa R" last="King">Lisa R. King</name><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name><name sortKey="Manischewitz, Jody" sort="Manischewitz, Jody" uniqKey="Manischewitz J" first="Jody" last="Manischewitz">Jody Manischewitz</name><name sortKey="Rivera, Yonaira" sort="Rivera, Yonaira" uniqKey="Rivera Y" first="Yonaira" last="Rivera">Yonaira Rivera</name><name sortKey="Sallusto, Federica" sort="Sallusto, Federica" uniqKey="Sallusto F" first="Federica" last="Sallusto">Federica Sallusto</name><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P" last="Simmons">Cameron P. Simmons</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Suguitan, Amorsolo L" sort="Suguitan, Amorsolo L" uniqKey="Suguitan A" first="Amorsolo L" last="Suguitan">Amorsolo L. Suguitan</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Khurana, Surender" sort="Khurana, Surender" uniqKey="Khurana S" first="Surender" last="Khurana">Surender Khurana</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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