Antigenic Fingerprinting of H5N1 Avian Influenza Using Convalescent Sera and Monoclonal Antibodies Reveals Potential Vaccine and Diagnostic Targets
Identifieur interne : 004069 ( Main/Merge ); précédent : 004068; suivant : 004070Antigenic Fingerprinting of H5N1 Avian Influenza Using Convalescent Sera and Monoclonal Antibodies Reveals Potential Vaccine and Diagnostic Targets
Auteurs : Surender Khurana [États-Unis] ; Amorsolo L. Suguitan [États-Unis] ; Yonaira Rivera [États-Unis] ; Cameron P. Simmons [Viêt Nam] ; Antonio Lanzavecchia [Suisse] ; Federica Sallusto [Suisse] ; Jody Manischewitz [États-Unis] ; Lisa R. King [États-Unis] ; Kanta Subbarao [États-Unis] ; Hana Golding [États-Unis]Source :
- PLoS Medicine [ 1549-1277 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux, Antigènes viraux (immunologie), Banque génomique, Cartographie épitopique, Convalescence, Facteurs de virulence, Grippe chez les oiseaux (immunologie), Grippe chez les oiseaux (virologie), Humains, Oiseaux, Protéines de la matrice virale (immunologie), Protéines virales (antagonistes et inhibiteurs), Protéines virales (immunologie), Sialidase (immunologie), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (pathogénicité), Vaccins antigrippaux (immunologie), Vietnam, Épitopes (sang).
- MESH :
- antagonistes et inhibiteurs : Protéines virales.
- immunologie : Antigènes viraux, Grippe chez les oiseaux, Protéines de la matrice virale, Protéines virales, Sialidase, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux.
- pathogénicité : Sous-type H5N1 du virus de la grippe A.
- sang : Épitopes.
- virologie : Grippe chez les oiseaux.
- Animaux, Anticorps monoclonaux, Banque génomique, Cartographie épitopique, Convalescence, Facteurs de virulence, Humains, Oiseaux, Vietnam.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal, Antigens, Viral (immunology), Birds, Convalescence, Epitope Mapping, Epitopes (blood), Genomic Library, Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H3N2 Subtype (immunology), Influenza A Virus, H5N1 Subtype (immunology), Influenza A Virus, H5N1 Subtype (pathogenicity), Influenza Vaccines (immunology), Influenza in Birds (immunology), Influenza in Birds (virology), Neuraminidase (immunology), Vietnam, Viral Matrix Proteins (immunology), Viral Proteins (antagonists & inhibitors), Viral Proteins (immunology), Virulence Factors.
- MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , blood : Epitopes.
- chemical , immunology : Antigens, Viral, Influenza Vaccines, Neuraminidase, Viral Matrix Proteins, Viral Proteins.
- chemical : Antibodies, Monoclonal, Virulence Factors.
- geographic : Vietnam.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A Virus, H5N1 Subtype, Influenza in Birds.
- pathogenicity : Influenza A Virus, H5N1 Subtype.
- virology : Influenza in Birds.
- Animals, Birds, Convalescence, Epitope Mapping, Genomic Library, Humans.
Abstract
Using whole-genome-fragment phage display libraries, Hana Golding and colleagues identify the viral epitopes recognized by serum antibodies in humans who have recovered from infection with H5N1 avian influenza.
Url:
DOI: 10.1371/journal.pmed.1000049
PubMed: 19381279
PubMed Central: 2661249
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PMC:2661249Le document en format XML
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<term>Cartographie épitopique</term>
<term>Convalescence</term>
<term>Facteurs de virulence</term>
<term>Humains</term>
<term>Oiseaux</term>
<term>Vietnam</term>
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<front><div type="abstract" xml:lang="en"><p>Using whole-genome-fragment phage display libraries, Hana Golding and colleagues identify the viral epitopes recognized by serum antibodies in humans who have recovered from infection with H5N1 avian influenza.</p>
</div>
</front>
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