Antigenic Fingerprinting of H5N1 Avian Influenza Using Convalescent Sera and Monoclonal Antibodies Reveals Potential Vaccine and Diagnostic Targets
Identifieur interne : 000867 ( Ncbi/Merge ); précédent : 000866; suivant : 000868Antigenic Fingerprinting of H5N1 Avian Influenza Using Convalescent Sera and Monoclonal Antibodies Reveals Potential Vaccine and Diagnostic Targets
Auteurs : Surender Khurana [États-Unis] ; Amorsolo L. Suguitan [États-Unis] ; Yonaira Rivera [États-Unis] ; Cameron P. Simmons [Viêt Nam] ; Antonio Lanzavecchia [Suisse] ; Federica Sallusto [Suisse] ; Jody Manischewitz [États-Unis] ; Lisa R. King [États-Unis] ; Kanta Subbarao [États-Unis] ; Hana Golding [États-Unis]Source :
- PLoS Medicine [ 1549-1277 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux, Antigènes viraux (immunologie), Banque génomique, Cartographie épitopique, Convalescence, Facteurs de virulence, Grippe chez les oiseaux (immunologie), Grippe chez les oiseaux (virologie), Humains, Oiseaux, Protéines de la matrice virale (immunologie), Protéines virales (antagonistes et inhibiteurs), Protéines virales (immunologie), Sialidase (immunologie), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (pathogénicité), Vaccins antigrippaux (immunologie), Vietnam, Épitopes (sang).
- MESH :
- antagonistes et inhibiteurs : Protéines virales.
- immunologie : Antigènes viraux, Grippe chez les oiseaux, Protéines de la matrice virale, Protéines virales, Sialidase, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux.
- pathogénicité : Sous-type H5N1 du virus de la grippe A.
- sang : Épitopes.
- virologie : Grippe chez les oiseaux.
- Animaux, Anticorps monoclonaux, Banque génomique, Cartographie épitopique, Convalescence, Facteurs de virulence, Humains, Oiseaux, Vietnam.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal, Antigens, Viral (immunology), Birds, Convalescence, Epitope Mapping, Epitopes (blood), Genomic Library, Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H3N2 Subtype (immunology), Influenza A Virus, H5N1 Subtype (immunology), Influenza A Virus, H5N1 Subtype (pathogenicity), Influenza Vaccines (immunology), Influenza in Birds (immunology), Influenza in Birds (virology), Neuraminidase (immunology), Vietnam, Viral Matrix Proteins (immunology), Viral Proteins (antagonists & inhibitors), Viral Proteins (immunology), Virulence Factors.
- MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , blood : Epitopes.
- chemical , immunology : Antigens, Viral, Influenza Vaccines, Neuraminidase, Viral Matrix Proteins, Viral Proteins.
- chemical : Antibodies, Monoclonal, Virulence Factors.
- geographic : Vietnam.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A Virus, H5N1 Subtype, Influenza in Birds.
- pathogenicity : Influenza A Virus, H5N1 Subtype.
- virology : Influenza in Birds.
- Animals, Birds, Convalescence, Epitope Mapping, Genomic Library, Humans.
Abstract
Using whole-genome-fragment phage display libraries, Hana Golding and colleagues identify the viral epitopes recognized by serum antibodies in humans who have recovered from infection with H5N1 avian influenza.
Url:
DOI: 10.1371/journal.pmed.1000049
PubMed: 19381279
PubMed Central: 2661249
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PMC:2661249Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Using whole-genome-fragment phage display libraries, Hana Golding and colleagues identify the viral epitopes recognized by serum antibodies in humans who have recovered from infection with H5N1 avian influenza.</p>
</div>
</front>
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<country xml:lang="fr">Viêt Nam</country>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
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</nlm:aff>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antigenic Fingerprinting of H5N1 Avian Influenza Using Convalescent Sera and Monoclonal Antibodies Reveals Potential Vaccine and Diagnostic Targets</title>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
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</nlm:aff>
<country xml:lang="fr">Viêt Nam</country>
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<country xml:lang="fr">Suisse</country>
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<country xml:lang="fr">Suisse</country>
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<affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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<author><name sortKey="Golding, Hana" sort="Golding, Hana" uniqKey="Golding H" first="Hana" last="Golding">Hana Golding</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<series><title level="j">PLoS Medicine</title>
<idno type="ISSN">1549-1277</idno>
<idno type="eISSN">1549-1676</idno>
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<front><div type="abstract" xml:lang="en"><p>Using whole-genome-fragment phage display libraries, Hana Golding and colleagues identify the viral epitopes recognized by serum antibodies in humans who have recovered from infection with H5N1 avian influenza.</p>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antigenic fingerprinting of H5N1 avian influenza using convalescent sera and monoclonal antibodies reveals potential vaccine and diagnostic targets.</title>
<author><name sortKey="Khurana, Surender" sort="Khurana, Surender" uniqKey="Khurana S" first="Surender" last="Khurana">Surender Khurana</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Suguitan, Amorsolo L" sort="Suguitan, Amorsolo L" uniqKey="Suguitan A" first="Amorsolo L" last="Suguitan">Amorsolo L. Suguitan</name>
</author>
<author><name sortKey="Rivera, Yonaira" sort="Rivera, Yonaira" uniqKey="Rivera Y" first="Yonaira" last="Rivera">Yonaira Rivera</name>
</author>
<author><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P" last="Simmons">Cameron P. Simmons</name>
</author>
<author><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name>
</author>
<author><name sortKey="Sallusto, Federica" sort="Sallusto, Federica" uniqKey="Sallusto F" first="Federica" last="Sallusto">Federica Sallusto</name>
</author>
<author><name sortKey="Manischewitz, Jody" sort="Manischewitz, Jody" uniqKey="Manischewitz J" first="Jody" last="Manischewitz">Jody Manischewitz</name>
</author>
<author><name sortKey="King, Lisa R" sort="King, Lisa R" uniqKey="King L" first="Lisa R" last="King">Lisa R. King</name>
</author>
<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
</author>
<author><name sortKey="Golding, Hana" sort="Golding, Hana" uniqKey="Golding H" first="Hana" last="Golding">Hana Golding</name>
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<idno type="pmid">19381279</idno>
<idno type="doi">10.1371/journal.pmed.1000049</idno>
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<author><name sortKey="Khurana, Surender" sort="Khurana, Surender" uniqKey="Khurana S" first="Surender" last="Khurana">Surender Khurana</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Suguitan, Amorsolo L" sort="Suguitan, Amorsolo L" uniqKey="Suguitan A" first="Amorsolo L" last="Suguitan">Amorsolo L. Suguitan</name>
</author>
<author><name sortKey="Rivera, Yonaira" sort="Rivera, Yonaira" uniqKey="Rivera Y" first="Yonaira" last="Rivera">Yonaira Rivera</name>
</author>
<author><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P" last="Simmons">Cameron P. Simmons</name>
</author>
<author><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name>
</author>
<author><name sortKey="Sallusto, Federica" sort="Sallusto, Federica" uniqKey="Sallusto F" first="Federica" last="Sallusto">Federica Sallusto</name>
</author>
<author><name sortKey="Manischewitz, Jody" sort="Manischewitz, Jody" uniqKey="Manischewitz J" first="Jody" last="Manischewitz">Jody Manischewitz</name>
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<author><name sortKey="King, Lisa R" sort="King, Lisa R" uniqKey="King L" first="Lisa R" last="King">Lisa R. King</name>
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<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
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<author><name sortKey="Golding, Hana" sort="Golding, Hana" uniqKey="Golding H" first="Hana" last="Golding">Hana Golding</name>
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<series><title level="j">PLoS medicine</title>
<idno type="eISSN">1549-1676</idno>
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<term>Antibodies, Monoclonal</term>
<term>Antigens, Viral (immunology)</term>
<term>Birds</term>
<term>Convalescence</term>
<term>Epitope Mapping</term>
<term>Epitopes (blood)</term>
<term>Genomic Library</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H3N2 Subtype (immunology)</term>
<term>Influenza A Virus, H5N1 Subtype (immunology)</term>
<term>Influenza A Virus, H5N1 Subtype (pathogenicity)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza in Birds (immunology)</term>
<term>Influenza in Birds (virology)</term>
<term>Neuraminidase (immunology)</term>
<term>Vietnam</term>
<term>Viral Matrix Proteins (immunology)</term>
<term>Viral Proteins (antagonists & inhibitors)</term>
<term>Viral Proteins (immunology)</term>
<term>Virulence Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps monoclonaux</term>
<term>Antigènes viraux (immunologie)</term>
<term>Banque génomique</term>
<term>Cartographie épitopique</term>
<term>Convalescence</term>
<term>Facteurs de virulence</term>
<term>Grippe chez les oiseaux (immunologie)</term>
<term>Grippe chez les oiseaux (virologie)</term>
<term>Humains</term>
<term>Oiseaux</term>
<term>Protéines de la matrice virale (immunologie)</term>
<term>Protéines virales (antagonistes et inhibiteurs)</term>
<term>Protéines virales (immunologie)</term>
<term>Sialidase (immunologie)</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H3N2 du virus de la grippe A (immunologie)</term>
<term>Sous-type H5N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H5N1 du virus de la grippe A (pathogénicité)</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Vietnam</term>
<term>Épitopes (sang)</term>
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</keywords>
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<term>Influenza Vaccines</term>
<term>Neuraminidase</term>
<term>Viral Matrix Proteins</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Vietnam</term>
</keywords>
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</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term>
<term>Grippe chez les oiseaux</term>
<term>Protéines de la matrice virale</term>
<term>Protéines virales</term>
<term>Sialidase</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Vaccins antigrippaux</term>
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<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza in Birds</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H5N1 du virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Épitopes</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe chez les oiseaux</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza in Birds</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Birds</term>
<term>Convalescence</term>
<term>Epitope Mapping</term>
<term>Genomic Library</term>
<term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Anticorps monoclonaux</term>
<term>Banque génomique</term>
<term>Cartographie épitopique</term>
<term>Convalescence</term>
<term>Facteurs de virulence</term>
<term>Humains</term>
<term>Oiseaux</term>
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<front><div type="abstract" xml:lang="en">Transmission of highly pathogenic avian H5N1 viruses from poultry to humans have raised fears of an impending influenza pandemic. Concerted efforts are underway to prepare effective vaccines and therapies including polyclonal or monoclonal antibodies against H5N1. Current efforts are hampered by the paucity of information on protective immune responses against avian influenza. Characterizing the B cell responses in convalescent individuals could help in the design of future vaccines and therapeutics.</div>
</front>
</TEI>
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