Topiramate therapy for paroxysmal kinesigenic choreoathetosis
Identifieur interne : 003699 ( Main/Exploration ); précédent : 003698; suivant : 003700Topiramate therapy for paroxysmal kinesigenic choreoathetosis
Auteurs : Yuan-Gui Huang [République populaire de Chine] ; Yun-Chun Chen [République populaire de Chine] ; Fang Du [République populaire de Chine] ; Rui Li [République populaire de Chine] ; Ge-Lin Xu [République populaire de Chine] ; Wen Jiang [République populaire de Chine] ; Jing Huang [République populaire de Chine]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-01.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adolescent, Adult, Anticonvulsants (therapeutic use), Athetosis (complications), Athetosis (drug therapy), Child, Chorea (complications), Chorea (drug therapy), Choreoathetosis, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Fructose (analogs & derivatives), Fructose (therapeutic use), Humans, Male, Motor control, Nervous system diseases, Topiramate, Treatment, Treatment Outcome, paroxysmal kinesigenic choreoathetosis, topiramate, treatment.
- MESH :
- chemical , analogs & derivatives : Fructose.
- chemical , therapeutic use : Anticonvulsants, Fructose.
- complications : Athetosis, Chorea.
- drug therapy : Athetosis, Chorea.
- Adolescent, Adult, Child, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Male, Treatment Outcome.
Abstract
We observed the clinical efficacy of topiramate for paroxysmal kinesigenic choreoathetosis (PKC). Topiramate was administered as a monotherapy with titrated dosages to 8 patients with PKC. Target daily dose of topiramate was 100 to 200 mg; the follow‐up period ranged from 8 months to 2 years. All of the patients became attack‐free, and side effects were mild. The results show that topiramate is effective as a monotherapy for treating patients with PKC. The response to topiramate indicates that the disease may be caused by an ion channel defect. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20283
Affiliations:
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Le document en format XML
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<term>Athetosis (drug therapy)</term>
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<term>Chorea (complications)</term>
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<term>Female</term>
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<front><div type="abstract" xml:lang="en">We observed the clinical efficacy of topiramate for paroxysmal kinesigenic choreoathetosis (PKC). Topiramate was administered as a monotherapy with titrated dosages to 8 patients with PKC. Target daily dose of topiramate was 100 to 200 mg; the follow‐up period ranged from 8 months to 2 years. All of the patients became attack‐free, and side effects were mild. The results show that topiramate is effective as a monotherapy for treating patients with PKC. The response to topiramate indicates that the disease may be caused by an ion channel defect. © 2004 Movement Disorder Society</div>
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<name sortKey="Xu, Ge In" sort="Xu, Ge In" uniqKey="Xu G" first="Ge-Lin" last="Xu">Ge-Lin Xu</name>
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