Topiramate therapy for paroxysmal kinesigenic choreoathetosis.
Identifieur interne : 001060 ( Ncbi/Curation ); précédent : 001059; suivant : 001061Topiramate therapy for paroxysmal kinesigenic choreoathetosis.
Auteurs : Yuan-Gui Huang [République populaire de Chine] ; Yun-Chun Chen ; Fang Du ; Rui Li ; Ge-Lin Xu ; Wen Jiang ; Jing HuangSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Adolescent, Adult, Anticonvulsants (therapeutic use), Athetosis (complications), Athetosis (drug therapy), Child, Chorea (complications), Chorea (drug therapy), Dose-Response Relationship, Drug, Female, Follow-Up Studies, Fructose (analogs & derivatives), Fructose (therapeutic use), Humans, Male, Treatment Outcome.
- MESH :
- chemical , analogs & derivatives : Fructose.
- chemical , therapeutic use : Anticonvulsants, Fructose.
- complications : Athetosis, Chorea.
- drug therapy : Athetosis, Chorea.
- Adolescent, Adult, Child, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Male, Treatment Outcome.
Abstract
We observed the clinical efficacy of topiramate for paroxysmal kinesigenic choreoathetosis (PKC). Topiramate was administered as a monotherapy with titrated dosages to 8 patients with PKC. Target daily dose of topiramate was 100 to 200 mg; the follow-up period ranged from 8 months to 2 years. All of the patients became attack-free, and side effects were mild. The results show that topiramate is effective as a monotherapy for treating patients with PKC. The response to topiramate indicates that the disease may be caused by an ion channel defect.
DOI: 10.1002/mds.20283
PubMed: 15390133
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pubmed:15390133Le document en format XML
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Rui" uniqKey="Li R" first="Rui" last="Li">Rui Li</name></author><author><name sortKey="Xu, Ge Lin" sort="Xu, Ge Lin" uniqKey="Xu G" first="Ge-Lin" last="Xu">Ge-Lin Xu</name></author><author><name sortKey="Jiang, Wen" sort="Jiang, Wen" uniqKey="Jiang W" first="Wen" last="Jiang">Wen Jiang</name></author><author><name sortKey="Huang, Jing" sort="Huang, Jing" uniqKey="Huang J" first="Jing" last="Huang">Jing Huang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:15390133</idno><idno type="pmid">15390133</idno><idno type="doi">10.1002/mds.20283</idno><idno type="wicri:Area/PubMed/Corpus">003228</idno><idno type="wicri:Area/PubMed/Curation">003228</idno><idno type="wicri:Area/PubMed/Checkpoint">002F31</idno><idno type="wicri:Area/Ncbi/Merge">001060</idno><idno type="wicri:Area/Ncbi/Curation">001060</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Topiramate therapy for 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Ge Lin" sort="Xu, Ge Lin" uniqKey="Xu G" first="Ge-Lin" last="Xu">Ge-Lin Xu</name></author><author><name sortKey="Jiang, Wen" sort="Jiang, Wen" uniqKey="Jiang W" first="Wen" last="Jiang">Wen Jiang</name></author><author><name sortKey="Huang, Jing" sort="Huang, Jing" uniqKey="Huang J" first="Jing" last="Huang">Jing Huang</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Anticonvulsants (therapeutic use)</term><term>Athetosis (complications)</term><term>Athetosis (drug therapy)</term><term>Child</term><term>Chorea (complications)</term><term>Chorea (drug therapy)</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Follow-Up Studies</term><term>Fructose (analogs & derivatives)</term><term>Fructose (therapeutic use)</term><term>Humans</term><term>Male</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Fructose</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anticonvulsants</term><term>Fructose</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Athetosis</term><term>Chorea</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Athetosis</term><term>Chorea</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We observed the clinical efficacy of topiramate for paroxysmal kinesigenic choreoathetosis (PKC). Topiramate was administered as a monotherapy with titrated dosages to 8 patients with PKC. Target daily dose of topiramate was 100 to 200 mg; the follow-up period ranged from 8 months to 2 years. All of the patients became attack-free, and side effects were mild. The results show that topiramate is effective as a monotherapy for treating patients with PKC. The response to topiramate indicates that the disease may be caused by an ion channel defect.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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