Topiramate therapy for paroxysmal kinesigenic choreoathetosis.
Identifieur interne : 001060 ( Ncbi/Merge ); précédent : 001059; suivant : 001061Topiramate therapy for paroxysmal kinesigenic choreoathetosis.
Auteurs : Yuan-Gui Huang [République populaire de Chine] ; Yun-Chun Chen ; Fang Du ; Rui Li ; Ge-Lin Xu ; Wen Jiang ; Jing HuangSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Adolescent, Adult, Anticonvulsants (therapeutic use), Athetosis (complications), Athetosis (drug therapy), Child, Chorea (complications), Chorea (drug therapy), Dose-Response Relationship, Drug, Female, Follow-Up Studies, Fructose (analogs & derivatives), Fructose (therapeutic use), Humans, Male, Treatment Outcome.
- MESH :
- chemical , analogs & derivatives : Fructose.
- chemical , therapeutic use : Anticonvulsants, Fructose.
- complications : Athetosis, Chorea.
- drug therapy : Athetosis, Chorea.
- Adolescent, Adult, Child, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Male, Treatment Outcome.
Abstract
We observed the clinical efficacy of topiramate for paroxysmal kinesigenic choreoathetosis (PKC). Topiramate was administered as a monotherapy with titrated dosages to 8 patients with PKC. Target daily dose of topiramate was 100 to 200 mg; the follow-up period ranged from 8 months to 2 years. All of the patients became attack-free, and side effects were mild. The results show that topiramate is effective as a monotherapy for treating patients with PKC. The response to topiramate indicates that the disease may be caused by an ion channel defect.
DOI: 10.1002/mds.20283
PubMed: 15390133
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pubmed:15390133Le document en format XML
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<author><name sortKey="Huang, Yuan Gui" sort="Huang, Yuan Gui" uniqKey="Huang Y" first="Yuan-Gui" last="Huang">Yuan-Gui Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>The Department of Neurology, Xijing Hospital, the Fourth Military Medical University, Shaanxi, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Department of Neurology, Xijing Hospital, the Fourth Military Medical University, Shaanxi</wicri:regionArea>
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<author><name sortKey="Chen, Yun Chun" sort="Chen, Yun Chun" uniqKey="Chen Y" first="Yun-Chun" last="Chen">Yun-Chun Chen</name>
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<author><name sortKey="Du, Fang" sort="Du, Fang" uniqKey="Du F" first="Fang" last="Du">Fang Du</name>
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<author><name sortKey="Li, Rui" sort="Li, Rui" uniqKey="Li R" first="Rui" last="Li">Rui Li</name>
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<author><name sortKey="Xu, Ge Lin" sort="Xu, Ge Lin" uniqKey="Xu G" first="Ge-Lin" last="Xu">Ge-Lin Xu</name>
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<author><name sortKey="Jiang, Wen" sort="Jiang, Wen" uniqKey="Jiang W" first="Wen" last="Jiang">Wen Jiang</name>
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<author><name sortKey="Huang, Jing" sort="Huang, Jing" uniqKey="Huang J" first="Jing" last="Huang">Jing Huang</name>
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<author><name sortKey="Li, Rui" sort="Li, Rui" uniqKey="Li R" first="Rui" last="Li">Rui Li</name>
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<author><name sortKey="Xu, Ge Lin" sort="Xu, Ge Lin" uniqKey="Xu G" first="Ge-Lin" last="Xu">Ge-Lin Xu</name>
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<author><name sortKey="Jiang, Wen" sort="Jiang, Wen" uniqKey="Jiang W" first="Wen" last="Jiang">Wen Jiang</name>
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<term>Anticonvulsants (therapeutic use)</term>
<term>Athetosis (complications)</term>
<term>Athetosis (drug therapy)</term>
<term>Child</term>
<term>Chorea (complications)</term>
<term>Chorea (drug therapy)</term>
<term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Fructose (analogs & derivatives)</term>
<term>Fructose (therapeutic use)</term>
<term>Humans</term>
<term>Male</term>
<term>Treatment Outcome</term>
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<term>Chorea</term>
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<term>Adult</term>
<term>Child</term>
<term>Dose-Response Relationship, Drug</term>
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<front><div type="abstract" xml:lang="en">We observed the clinical efficacy of topiramate for paroxysmal kinesigenic choreoathetosis (PKC). Topiramate was administered as a monotherapy with titrated dosages to 8 patients with PKC. Target daily dose of topiramate was 100 to 200 mg; the follow-up period ranged from 8 months to 2 years. All of the patients became attack-free, and side effects were mild. The results show that topiramate is effective as a monotherapy for treating patients with PKC. The response to topiramate indicates that the disease may be caused by an ion channel defect.</div>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<ArticleTitle>Topiramate therapy for paroxysmal kinesigenic choreoathetosis.</ArticleTitle>
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<Abstract><AbstractText>We observed the clinical efficacy of topiramate for paroxysmal kinesigenic choreoathetosis (PKC). Topiramate was administered as a monotherapy with titrated dosages to 8 patients with PKC. Target daily dose of topiramate was 100 to 200 mg; the follow-up period ranged from 8 months to 2 years. All of the patients became attack-free, and side effects were mild. The results show that topiramate is effective as a monotherapy for treating patients with PKC. The response to topiramate indicates that the disease may be caused by an ion channel defect.</AbstractText>
<CopyrightInformation>(c) 2004 Movement Disorder Society.</CopyrightInformation>
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