Severe hypokinesis caused by paraneoplastic anti‐Ma2 encephalitis associated with bilateral intratubular germ‐cell neoplasm of the testes
Identifieur interne : 002B84 ( Main/Exploration ); précédent : 002B83; suivant : 002B85Severe hypokinesis caused by paraneoplastic anti‐Ma2 encephalitis associated with bilateral intratubular germ‐cell neoplasm of the testes
Auteurs : Lumine Matsumoto [Japon] ; Tomotaka Yamamoto [Japon] ; Mana Higashihara [Japon] ; Izumi Sugimoto [Japon] ; Hisatomo Kowa [Japon] ; Junji Shibahara [Japon] ; Koichiro Nakamura [Japon] ; Jun Shimizu [Japon] ; Yoshikazu Ugawa [Japon] ; Jun Goto [Japon] ; Josep Dalmau [États-Unis] ; Shoji Tsuji [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-04-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Antigens, Neoplasm (immunology), Autoantibodies (blood), Brain (immunology), Brain (pathology), Carcinoma in Situ (diagnosis), Carcinoma in Situ (immunology), Carcinoma in Situ (pathology), Carcinoma in Situ (surgery), Disease Progression, Encephalitis, Fatal Outcome, Humans, Hypokinesia (diagnosis), Hypokinesia (immunology), Hypokinesia (pathology), Limbic Encephalitis (diagnosis), Limbic Encephalitis (immunology), Limbic Encephalitis (pathology), Magnetic Resonance Imaging, Male, Neoplasms, Germ Cell and Embryonal (diagnosis), Neoplasms, Germ Cell and Embryonal (immunology), Neoplasms, Germ Cell and Embryonal (pathology), Neoplasms, Germ Cell and Embryonal (surgery), Nerve Tissue Proteins (immunology), Nervous system diseases, Orchiectomy, Paraneoplastic Syndromes (diagnosis), Paraneoplastic Syndromes (immunology), Paraneoplastic Syndromes (pathology), Paraneoplastic syndrome, Parkinsonism, Seminiferous Tubules (pathology), Testicular Neoplasms (diagnosis), Testicular Neoplasms (immunology), Testicular Neoplasms (pathology), Testicular Neoplasms (surgery), Tumor, anti‐Ma2 paraneoplastic encephalitis, hypokinesis, intratubular germ‐cell neoplasia.
- MESH :
- chemical , blood : Autoantibodies.
- chemical , immunology : Antigens, Neoplasm, Nerve Tissue Proteins.
- diagnosis : Carcinoma in Situ, Hypokinesia, Limbic Encephalitis, Neoplasms, Germ Cell and Embryonal, Paraneoplastic Syndromes, Testicular Neoplasms.
- immunology : Brain, Carcinoma in Situ, Hypokinesia, Limbic Encephalitis, Neoplasms, Germ Cell and Embryonal, Paraneoplastic Syndromes, Testicular Neoplasms.
- pathology : Brain, Carcinoma in Situ, Hypokinesia, Limbic Encephalitis, Neoplasms, Germ Cell and Embryonal, Paraneoplastic Syndromes, Seminiferous Tubules, Testicular Neoplasms.
- surgery : Carcinoma in Situ, Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms.
- Adult, Disease Progression, Fatal Outcome, Humans, Magnetic Resonance Imaging, Male, Orchiectomy.
Abstract
We report a 40‐year‐old man with severe hypokinesis as paraneoplastic manifestation of a microscopic “carcinoma in situ” of the testis. The young age of the patient, along with progressive neurologic deterioration, detection of anti‐Ma2 antibodies, and ultrasound findings of bilateral microcalcifications, led to bilateral orchiectomy, revealing the tumor in both testes. After orchiectomy, neurological symptoms stabilized, but the patient eventually died of systemic complications caused by his severe neurological deficits. Anti‐Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits. © 2006 Movement Disorder Society
Url:
- https://api.istex.fr/document/5EB5E12C59D842A3A97211F6ABC9D543D07BD0CA/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1909751
DOI: 10.1002/mds.21314
Affiliations:
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Le document en format XML
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Kowa</name></author><author><name sortKey="Shibahara, Junji" sort="Shibahara, Junji" uniqKey="Shibahara J" first="Junji" last="Shibahara">Junji Shibahara</name></author><author><name sortKey="Nakamura, Koichiro" sort="Nakamura, Koichiro" uniqKey="Nakamura K" first="Koichiro" last="Nakamura">Koichiro Nakamura</name></author><author><name sortKey="Shimizu, Jun" sort="Shimizu, Jun" uniqKey="Shimizu J" first="Jun" last="Shimizu">Jun Shimizu</name></author><author><name sortKey="Ugawa, Yoshikazu" sort="Ugawa, Yoshikazu" uniqKey="Ugawa Y" first="Yoshikazu" last="Ugawa">Yoshikazu Ugawa</name></author><author><name sortKey="Goto, Jun" sort="Goto, Jun" uniqKey="Goto J" first="Jun" last="Goto">Jun Goto</name></author><author><name sortKey="Dalmau, Josep" sort="Dalmau, Josep" uniqKey="Dalmau J" first="Josep" last="Dalmau">Josep Dalmau</name></author><author><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji 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hypokinesis caused by paraneoplastic anti‐Ma2 encephalitis associated with bilateral intratubular germ‐cell neoplasm of the testes</title><author><name sortKey="Matsumoto, Lumine" sort="Matsumoto, Lumine" uniqKey="Matsumoto L" first="Lumine" last="Matsumoto">Lumine Matsumoto</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Yamamoto, Tomotaka" sort="Yamamoto, Tomotaka" uniqKey="Yamamoto T" first="Tomotaka" last="Yamamoto">Tomotaka Yamamoto</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Higashihara, Mana" sort="Higashihara, Mana" uniqKey="Higashihara M" first="Mana" last="Higashihara">Mana Higashihara</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Sugimoto, Izumi" sort="Sugimoto, Izumi" uniqKey="Sugimoto I" first="Izumi" last="Sugimoto">Izumi Sugimoto</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Kowa, Hisatomo" sort="Kowa, Hisatomo" uniqKey="Kowa H" first="Hisatomo" last="Kowa">Hisatomo Kowa</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Shibahara, Junji" sort="Shibahara, Junji" uniqKey="Shibahara J" first="Junji" last="Shibahara">Junji Shibahara</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Nakamura, Koichiro" sort="Nakamura, Koichiro" uniqKey="Nakamura K" first="Koichiro" last="Nakamura">Koichiro Nakamura</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Shimizu, Jun" sort="Shimizu, Jun" uniqKey="Shimizu J" first="Jun" last="Shimizu">Jun Shimizu</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Ugawa, Yoshikazu" sort="Ugawa, Yoshikazu" uniqKey="Ugawa Y" first="Yoshikazu" last="Ugawa">Yoshikazu Ugawa</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Goto, Jun" sort="Goto, Jun" uniqKey="Goto J" first="Jun" last="Goto">Jun Goto</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Dalmau, Josep" sort="Dalmau, Josep" uniqKey="Dalmau J" first="Josep" last="Dalmau">Josep Dalmau</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology (Division Neuro‐Oncology), University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-04-15">2007-04-15</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="728">728</biblScope><biblScope unit="page" to="731">731</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5EB5E12C59D842A3A97211F6ABC9D543D07BD0CA</idno><idno type="DOI">10.1002/mds.21314</idno><idno type="ArticleID">MDS21314</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antigens, Neoplasm (immunology)</term><term>Autoantibodies (blood)</term><term>Brain (immunology)</term><term>Brain (pathology)</term><term>Carcinoma in Situ (diagnosis)</term><term>Carcinoma in Situ (immunology)</term><term>Carcinoma in Situ (pathology)</term><term>Carcinoma in Situ (surgery)</term><term>Disease Progression</term><term>Encephalitis</term><term>Fatal Outcome</term><term>Humans</term><term>Hypokinesia (diagnosis)</term><term>Hypokinesia (immunology)</term><term>Hypokinesia (pathology)</term><term>Limbic Encephalitis (diagnosis)</term><term>Limbic Encephalitis (immunology)</term><term>Limbic Encephalitis (pathology)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Neoplasms, Germ Cell and Embryonal (diagnosis)</term><term>Neoplasms, Germ Cell and Embryonal (immunology)</term><term>Neoplasms, Germ Cell and Embryonal (pathology)</term><term>Neoplasms, Germ Cell and Embryonal (surgery)</term><term>Nerve Tissue Proteins (immunology)</term><term>Nervous system diseases</term><term>Orchiectomy</term><term>Paraneoplastic Syndromes (diagnosis)</term><term>Paraneoplastic Syndromes (immunology)</term><term>Paraneoplastic Syndromes (pathology)</term><term>Paraneoplastic syndrome</term><term>Parkinsonism</term><term>Seminiferous Tubules (pathology)</term><term>Testicular Neoplasms (diagnosis)</term><term>Testicular Neoplasms (immunology)</term><term>Testicular Neoplasms (pathology)</term><term>Testicular Neoplasms (surgery)</term><term>Tumor</term><term>anti‐Ma2 paraneoplastic encephalitis</term><term>hypokinesis</term><term>intratubular germ‐cell neoplasia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Autoantibodies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Neoplasm</term><term>Nerve Tissue Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Carcinoma in Situ</term><term>Hypokinesia</term><term>Limbic Encephalitis</term><term>Neoplasms, Germ Cell and Embryonal</term><term>Paraneoplastic Syndromes</term><term>Testicular Neoplasms</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brain</term><term>Carcinoma in Situ</term><term>Hypokinesia</term><term>Limbic Encephalitis</term><term>Neoplasms, Germ Cell and Embryonal</term><term>Paraneoplastic Syndromes</term><term>Testicular Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Carcinoma in Situ</term><term>Hypokinesia</term><term>Limbic Encephalitis</term><term>Neoplasms, Germ Cell and Embryonal</term><term>Paraneoplastic Syndromes</term><term>Seminiferous Tubules</term><term>Testicular Neoplasms</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Carcinoma in Situ</term><term>Neoplasms, Germ Cell and Embryonal</term><term>Testicular Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Disease Progression</term><term>Fatal Outcome</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Orchiectomy</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Encéphalite</term><term>Paranéoplasique syndrome</term><term>Parkinsonisme</term><term>Système nerveux pathologie</term><term>Tumeur</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report a 40‐year‐old man with severe hypokinesis as paraneoplastic manifestation of a microscopic “carcinoma in situ” of the testis. The young age of the patient, along with progressive neurologic deterioration, detection of anti‐Ma2 antibodies, and ultrasound findings of bilateral microcalcifications, led to bilateral orchiectomy, revealing the tumor in both testes. After orchiectomy, neurological symptoms stabilized, but the patient eventually died of systemic complications caused by his severe neurological deficits. Anti‐Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Pennsylvanie</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Matsumoto, Lumine" sort="Matsumoto, Lumine" uniqKey="Matsumoto L" first="Lumine" last="Matsumoto">Lumine Matsumoto</name></noRegion><name sortKey="Goto, Jun" sort="Goto, Jun" uniqKey="Goto J" first="Jun" last="Goto">Jun Goto</name><name sortKey="Higashihara, Mana" sort="Higashihara, Mana" uniqKey="Higashihara M" first="Mana" last="Higashihara">Mana Higashihara</name><name sortKey="Kowa, Hisatomo" sort="Kowa, Hisatomo" uniqKey="Kowa H" first="Hisatomo" last="Kowa">Hisatomo Kowa</name><name sortKey="Nakamura, Koichiro" sort="Nakamura, Koichiro" uniqKey="Nakamura K" first="Koichiro" last="Nakamura">Koichiro Nakamura</name><name sortKey="Shibahara, Junji" sort="Shibahara, Junji" uniqKey="Shibahara J" first="Junji" last="Shibahara">Junji Shibahara</name><name sortKey="Shimizu, Jun" sort="Shimizu, Jun" uniqKey="Shimizu J" first="Jun" last="Shimizu">Jun Shimizu</name><name sortKey="Sugimoto, Izumi" sort="Sugimoto, Izumi" uniqKey="Sugimoto I" first="Izumi" last="Sugimoto">Izumi Sugimoto</name><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name><name sortKey="Ugawa, Yoshikazu" sort="Ugawa, Yoshikazu" uniqKey="Ugawa Y" first="Yoshikazu" last="Ugawa">Yoshikazu Ugawa</name><name sortKey="Yamamoto, Tomotaka" sort="Yamamoto, Tomotaka" uniqKey="Yamamoto T" first="Tomotaka" last="Yamamoto">Tomotaka Yamamoto</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Dalmau, Josep" sort="Dalmau, Josep" uniqKey="Dalmau J" first="Josep" last="Dalmau">Josep Dalmau</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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