MovDisordV3, PascalFrancis, Curation, bibRecord, 001609

Severe hypokinesis caused by paraneoplastic anti-ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes

Identifieur interne : 001609 ( PascalFrancis/Curation ); précédent : 001608; suivant : 001610

Severe hypokinesis caused by paraneoplastic anti-ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes

Auteurs : Lumine Matsumoto [Japon] ; Tomotaka Yamamoto [Japon] ; Mana Higashihara [Japon] ; Izumi Sugimoto [Japon] ; Hisatomo Kowa [Japon] ; Junji Shibahara [Japon] ; Koichiro Nakamura [Japon] ; Jun Shimizu [Japon] ; Yoshikazu Ugawa [Japon] ; Jun Goto [Japon] ; Josep Dalmau [États-Unis] ; Shoji Tsuji [Japon]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0263045

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Paranéoplasique syndrome, Encéphalite, Tumeur, Parkinsonisme.

English descriptors

KwdEn :
- Encephalitis, Nervous system diseases, Paraneoplastic syndrome, Parkinsonism, Tumor.

Abstract

We report a 40-year-old man with severe hypokinesis as paraneoplastic manifestation of a microscopic "carcinoma in situ" of the testis. The young age of the patient, along with progressive neurologic deterioration, detection of anti-Ma2 antibodies, and ultrasound findings of bilateral micro-calcifications, led to bilateral orchiectomy, revealing the tumor in both testes. After orchiectomy, neurological symptoms stabilized, but the patient eventually died of systemic complications caused by his severe neurological deficits. Anti-Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits.

A01	`01`	`1`		`@0 0885-3185`
A03		`1`		`@0 Mov. disord.`
A05				`@2 22`
A06				`@2 5`
A08	`01`	`1`	`ENG`	`@1 Severe hypokinesis caused by paraneoplastic anti-ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes`
A11	`01`	`1`		`@1 MATSUMOTO (Lumine)`
A11	`02`	`1`		`@1 YAMAMOTO (Tomotaka)`
A11	`03`	`1`		`@1 HIGASHIHARA (Mana)`
A11	`04`	`1`		`@1 SUGIMOTO (Izumi)`
A11	`05`	`1`		`@1 KOWA (Hisatomo)`
A11	`06`	`1`		`@1 SHIBAHARA (Junji)`
A11	`07`	`1`		`@1 NAKAMURA (Koichiro)`
A11	`08`	`1`		`@1 SHIMIZU (Jun)`
A11	`09`	`1`		`@1 UGAWA (Yoshikazu)`
A11	`10`	`1`		`@1 GOTO (Jun)`
A11	`11`	`1`		`@1 DALMAU (Josep)`
A11	`12`	`1`		`@1 TSUJI (Shoji)`
A14	`01`			`@1 Department of Neurology, The University of Tokyo @2 Tokyo @3 JPN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 7 aut. @Z 8 aut. @Z 9 aut. @Z 10 aut. @Z 12 aut.`
A14	`02`			`@1 Department of Pathology, The University of Tokyo @2 Tokyo @3 JPN @Z 6 aut.`
A14	`03`			`@1 Department of Neurology (Division Neuro-Oncology), University of Pennsylvania @2 Philadelphia, Pennsylvania @3 USA @Z 11 aut.`
A20				`@1 728-731`
A21				`@1 2007`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 20953 @5 354000149439720230`
A44				`@0 0000 @1 © 2007 INIST-CNRS. All rights reserved.`
A45				`@0 11 ref.`
A47	`01`	`1`		`@0 07-0263045`
A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 We report a 40-year-old man with severe hypokinesis as paraneoplastic manifestation of a microscopic "carcinoma in situ" of the testis. The young age of the patient, along with progressive neurologic deterioration, detection of anti-Ma2 antibodies, and ultrasound findings of bilateral micro-calcifications, led to bilateral orchiectomy, revealing the tumor in both testes. After orchiectomy, neurological symptoms stabilized, but the patient eventually died of systemic complications caused by his severe neurological deficits. Anti-Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits.
C02	`01`	`X`		`@0 002B17`
C02	`02`	`X`		`@0 002B05C02A`
C02	`03`	`X`		`@0 002A25L`
C03	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 01`
C03	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 01`
C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Paranéoplasique syndrome @5 02`
C03	`02`	`X`	`ENG`	`@0 Paraneoplastic syndrome @5 02`
C03	`02`	`X`	`SPA`	`@0 Paraneoplásico síndrome @5 02`
C03	`03`	`X`	`FRE`	`@0 Encéphalite @5 03`
C03	`03`	`X`	`ENG`	`@0 Encephalitis @5 03`
C03	`03`	`X`	`SPA`	`@0 Encefalitis @5 03`
C03	`04`	`X`	`FRE`	`@0 Tumeur @5 04`
C03	`04`	`X`	`ENG`	`@0 Tumor @5 04`
C03	`04`	`X`	`SPA`	`@0 Tumor @5 04`
C03	`05`	`X`	`FRE`	`@0 Parkinsonisme @2 NM @5 05`
C03	`05`	`X`	`ENG`	`@0 Parkinsonism @2 NM @5 05`
C03	`05`	`X`	`SPA`	`@0 Parkinson síndrome @2 NM @5 05`
C07	`01`	`X`	`FRE`	`@0 Encéphale pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 38`
N21				`@1 176`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:07-0263045

Le document en format XML

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<author><name sortKey="Matsumoto, Lumine" sort="Matsumoto, Lumine" uniqKey="Matsumoto L" first="Lumine" last="Matsumoto">Lumine Matsumoto</name>
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<author><name sortKey="Kowa, Hisatomo" sort="Kowa, Hisatomo" uniqKey="Kowa H" first="Hisatomo" last="Kowa">Hisatomo Kowa</name>
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<author><name sortKey="Shibahara, Junji" sort="Shibahara, Junji" uniqKey="Shibahara J" first="Junji" last="Shibahara">Junji Shibahara</name>
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<author><name sortKey="Nakamura, Koichiro" sort="Nakamura, Koichiro" uniqKey="Nakamura K" first="Koichiro" last="Nakamura">Koichiro Nakamura</name>
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<author><name sortKey="Shimizu, Jun" sort="Shimizu, Jun" uniqKey="Shimizu J" first="Jun" last="Shimizu">Jun Shimizu</name>
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<author><name sortKey="Ugawa, Yoshikazu" sort="Ugawa, Yoshikazu" uniqKey="Ugawa Y" first="Yoshikazu" last="Ugawa">Yoshikazu Ugawa</name>
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<s2>Tokyo</s2>
<s3>JPN</s3>
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<author><name sortKey="Goto, Jun" sort="Goto, Jun" uniqKey="Goto J" first="Jun" last="Goto">Jun Goto</name>
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<author><name sortKey="Dalmau, Josep" sort="Dalmau, Josep" uniqKey="Dalmau J" first="Josep" last="Dalmau">Josep Dalmau</name>
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<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
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<author><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The University of Tokyo</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Severe hypokinesis caused by paraneoplastic anti-ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes</title>
<author><name sortKey="Matsumoto, Lumine" sort="Matsumoto, Lumine" uniqKey="Matsumoto L" first="Lumine" last="Matsumoto">Lumine Matsumoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The University of Tokyo</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<sZ>10 aut.</sZ>
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<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Yamamoto, Tomotaka" sort="Yamamoto, Tomotaka" uniqKey="Yamamoto T" first="Tomotaka" last="Yamamoto">Tomotaka Yamamoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The University of Tokyo</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
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</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Higashihara, Mana" sort="Higashihara, Mana" uniqKey="Higashihara M" first="Mana" last="Higashihara">Mana Higashihara</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The University of Tokyo</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
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<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Sugimoto, Izumi" sort="Sugimoto, Izumi" uniqKey="Sugimoto I" first="Izumi" last="Sugimoto">Izumi Sugimoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The University of Tokyo</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
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<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Kowa, Hisatomo" sort="Kowa, Hisatomo" uniqKey="Kowa H" first="Hisatomo" last="Kowa">Hisatomo Kowa</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The University of Tokyo</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Shibahara, Junji" sort="Shibahara, Junji" uniqKey="Shibahara J" first="Junji" last="Shibahara">Junji Shibahara</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pathology, The University of Tokyo</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Nakamura, Koichiro" sort="Nakamura, Koichiro" uniqKey="Nakamura K" first="Koichiro" last="Nakamura">Koichiro Nakamura</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The University of Tokyo</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Shimizu, Jun" sort="Shimizu, Jun" uniqKey="Shimizu J" first="Jun" last="Shimizu">Jun Shimizu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The University of Tokyo</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
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<sZ>3 aut.</sZ>
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<sZ>10 aut.</sZ>
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<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Ugawa, Yoshikazu" sort="Ugawa, Yoshikazu" uniqKey="Ugawa Y" first="Yoshikazu" last="Ugawa">Yoshikazu Ugawa</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The University of Tokyo</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
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<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Goto, Jun" sort="Goto, Jun" uniqKey="Goto J" first="Jun" last="Goto">Jun Goto</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The University of Tokyo</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
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<author><name sortKey="Dalmau, Josep" sort="Dalmau, Josep" uniqKey="Dalmau J" first="Josep" last="Dalmau">Josep Dalmau</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology (Division Neuro-Oncology), University of Pennsylvania</s1>
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<s3>USA</s3>
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<country>États-Unis</country>
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<author><name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, The University of Tokyo</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
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<sZ>10 aut.</sZ>
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<country>Japon</country>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007">2007</date>
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<front><div type="abstract" xml:lang="en">We report a 40-year-old man with severe hypokinesis as paraneoplastic manifestation of a microscopic "carcinoma in situ" of the testis. The young age of the patient, along with progressive neurologic deterioration, detection of anti-Ma2 antibodies, and ultrasound findings of bilateral micro-calcifications, led to bilateral orchiectomy, revealing the tumor in both testes. After orchiectomy, neurological symptoms stabilized, but the patient eventually died of systemic complications caused by his severe neurological deficits. Anti-Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Severe hypokinesis caused by paraneoplastic anti-ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes

Severe hypokinesis caused by paraneoplastic anti-ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes

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