Severe Hypokinesis Caused by Paraneoplastic Anti-Ma2 Encephalitis Associated with Bilateral Intratubular Germ-Cell Neoplasm of the Testes
Identifieur interne : 000427 ( Pmc/Curation ); précédent : 000426; suivant : 000428Severe Hypokinesis Caused by Paraneoplastic Anti-Ma2 Encephalitis Associated with Bilateral Intratubular Germ-Cell Neoplasm of the Testes
Auteurs : Lumine Matsumoto [Japon] ; Tomotaka Yamamoto [Japon] ; Mana Higashihara [Japon] ; Izumi Sugimoto [Japon] ; Hisatomo Kowa [Japon] ; Junji Shibahara [Japon] ; Koichiro Nakamura [Japon] ; Jun Shimizu [Japon] ; Yoshikazu Ugawa [Japon] ; Jun Goto [Japon] ; Josep Dalmau [États-Unis] ; Shoji Tsuji [Japon]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
Abstract
We report a 40-year-old man with severe hypokinesis as paraneoplastic manifestation of a microscopic “carcinoma
Url:
DOI: 10.1002/mds.21314
PubMed: 17269131
PubMed Central: 1909751
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<author><name sortKey="Nakamura, Koichiro" sort="Nakamura, Koichiro" uniqKey="Nakamura K" first="Koichiro" last="Nakamura">Koichiro Nakamura</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<front><div type="abstract" xml:lang="en"><p id="P2">We report a 40-year-old man with severe hypokinesis as paraneoplastic manifestation of a microscopic “carcinoma <italic>in situ</italic>
” of the testis. The young age of the patient, along with progressive neurologic deterioration, detection of anti-Ma2 antibodies, and ultrasound findings of bilateral microcalcifications, led to bilateral orchiectomy, revealing the tumor in both testes. After orchiectomy, neurological symptoms stabilized, but the patient eventually died of systemic complications caused by his severe neurological deficits. Anti-Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5937</journal-id>
<journal-id journal-id-type="nlm-ta">Mov Disord</journal-id>
<journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title>
<issn pub-type="ppub">0885-3185</issn>
<issn pub-type="epub">1531-8257</issn>
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<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Severe Hypokinesis Caused by Paraneoplastic Anti-Ma2 Encephalitis Associated with Bilateral Intratubular Germ-Cell Neoplasm of the Testes</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Matsumoto</surname>
<given-names>Lumine</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yamamoto</surname>
<given-names>Tomotaka</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="author-notes" rid="FN1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Higashihara</surname>
<given-names>Mana</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sugimoto</surname>
<given-names>Izumi</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kowa</surname>
<given-names>Hisatomo</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shibahara</surname>
<given-names>Junji</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nakamura</surname>
<given-names>Koichiro</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shimizu</surname>
<given-names>Jun</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ugawa</surname>
<given-names>Yoshikazu</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Goto</surname>
<given-names>Jun</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dalmau</surname>
<given-names>Josep</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tsuji</surname>
<given-names>Shoji</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Neurology, The University of Tokyo, Tokyo, Japan</aff>
<aff id="A2"><label>2</label>
Department of Pathology, The University of Tokyo, Tokyo, Japan</aff>
<aff id="A3"><label>3</label>
Department of Neurology (Division Neuro-Oncology), University of Pennsylvania, Philadelphia, Pennsylvania, USA</aff>
<author-notes><fn fn-type="corresp" id="FN1"><label>*</label>
<p id="P1">Correspondence to: Tomotaka Yamamoto, MD, PhD, Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-8655, Japan. E-mail: <email>tyama-tky@umin.ac.jp</email>
</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>12</day>
<month>6</month>
<year>2007</year>
</pub-date>
<pub-date pub-type="ppub"><day>15</day>
<month>4</month>
<year>2007</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>5</day>
<month>7</month>
<year>2007</year>
</pub-date>
<volume>22</volume>
<issue>5</issue>
<fpage>728</fpage>
<lpage>731</lpage>
<abstract><p id="P2">We report a 40-year-old man with severe hypokinesis as paraneoplastic manifestation of a microscopic “carcinoma <italic>in situ</italic>
” of the testis. The young age of the patient, along with progressive neurologic deterioration, detection of anti-Ma2 antibodies, and ultrasound findings of bilateral microcalcifications, led to bilateral orchiectomy, revealing the tumor in both testes. After orchiectomy, neurological symptoms stabilized, but the patient eventually died of systemic complications caused by his severe neurological deficits. Anti-Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits.</p>
</abstract>
<kwd-group><kwd>anti-Ma2 paraneoplastic encephalitis</kwd>
<kwd>hypokinesis</kwd>
<kwd>Parkinsonism</kwd>
<kwd>intratubular germ-cell neoplasia</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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