Movement Disorders (revue)

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Severe Hypokinesis Caused by Paraneoplastic Anti-Ma2 Encephalitis Associated with Bilateral Intratubular Germ-Cell Neoplasm of the Testes

Identifieur interne : 000427 ( Pmc/Curation ); précédent : 000426; suivant : 000428

Severe Hypokinesis Caused by Paraneoplastic Anti-Ma2 Encephalitis Associated with Bilateral Intratubular Germ-Cell Neoplasm of the Testes

Auteurs : Lumine Matsumoto [Japon] ; Tomotaka Yamamoto [Japon] ; Mana Higashihara [Japon] ; Izumi Sugimoto [Japon] ; Hisatomo Kowa [Japon] ; Junji Shibahara [Japon] ; Koichiro Nakamura [Japon] ; Jun Shimizu [Japon] ; Yoshikazu Ugawa [Japon] ; Jun Goto [Japon] ; Josep Dalmau [États-Unis] ; Shoji Tsuji [Japon]

Source :

RBID : PMC:1909751

Abstract

We report a 40-year-old man with severe hypokinesis as paraneoplastic manifestation of a microscopic “carcinoma in situ” of the testis. The young age of the patient, along with progressive neurologic deterioration, detection of anti-Ma2 antibodies, and ultrasound findings of bilateral microcalcifications, led to bilateral orchiectomy, revealing the tumor in both testes. After orchiectomy, neurological symptoms stabilized, but the patient eventually died of systemic complications caused by his severe neurological deficits. Anti-Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits.


Url:
DOI: 10.1002/mds.21314
PubMed: 17269131
PubMed Central: 1909751

Links toward previous steps (curation, corpus...)


Links to Exploration step

PMC:1909751

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Severe Hypokinesis Caused by Paraneoplastic Anti-Ma2 Encephalitis Associated with Bilateral Intratubular Germ-Cell Neoplasm of the Testes</title>
<author>
<name sortKey="Matsumoto, Lumine" sort="Matsumoto, Lumine" uniqKey="Matsumoto L" first="Lumine" last="Matsumoto">Lumine Matsumoto</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yamamoto, Tomotaka" sort="Yamamoto, Tomotaka" uniqKey="Yamamoto T" first="Tomotaka" last="Yamamoto">Tomotaka Yamamoto</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Higashihara, Mana" sort="Higashihara, Mana" uniqKey="Higashihara M" first="Mana" last="Higashihara">Mana Higashihara</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sugimoto, Izumi" sort="Sugimoto, Izumi" uniqKey="Sugimoto I" first="Izumi" last="Sugimoto">Izumi Sugimoto</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kowa, Hisatomo" sort="Kowa, Hisatomo" uniqKey="Kowa H" first="Hisatomo" last="Kowa">Hisatomo Kowa</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Shibahara, Junji" sort="Shibahara, Junji" uniqKey="Shibahara J" first="Junji" last="Shibahara">Junji Shibahara</name>
<affiliation wicri:level="1">
<nlm:aff id="A2">Department of Pathology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Pathology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Nakamura, Koichiro" sort="Nakamura, Koichiro" uniqKey="Nakamura K" first="Koichiro" last="Nakamura">Koichiro Nakamura</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Shimizu, Jun" sort="Shimizu, Jun" uniqKey="Shimizu J" first="Jun" last="Shimizu">Jun Shimizu</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ugawa, Yoshikazu" sort="Ugawa, Yoshikazu" uniqKey="Ugawa Y" first="Yoshikazu" last="Ugawa">Yoshikazu Ugawa</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Goto, Jun" sort="Goto, Jun" uniqKey="Goto J" first="Jun" last="Goto">Jun Goto</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dalmau, Josep" sort="Dalmau, Josep" uniqKey="Dalmau J" first="Josep" last="Dalmau">Josep Dalmau</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Neurology (Division Neuro-Oncology), University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology (Division Neuro-Oncology), University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">17269131</idno>
<idno type="pmc">1909751</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1909751</idno>
<idno type="RBID">PMC:1909751</idno>
<idno type="doi">10.1002/mds.21314</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">000427</idno>
<idno type="wicri:Area/Pmc/Curation">000427</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Severe Hypokinesis Caused by Paraneoplastic Anti-Ma2 Encephalitis Associated with Bilateral Intratubular Germ-Cell Neoplasm of the Testes</title>
<author>
<name sortKey="Matsumoto, Lumine" sort="Matsumoto, Lumine" uniqKey="Matsumoto L" first="Lumine" last="Matsumoto">Lumine Matsumoto</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Yamamoto, Tomotaka" sort="Yamamoto, Tomotaka" uniqKey="Yamamoto T" first="Tomotaka" last="Yamamoto">Tomotaka Yamamoto</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Higashihara, Mana" sort="Higashihara, Mana" uniqKey="Higashihara M" first="Mana" last="Higashihara">Mana Higashihara</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Sugimoto, Izumi" sort="Sugimoto, Izumi" uniqKey="Sugimoto I" first="Izumi" last="Sugimoto">Izumi Sugimoto</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Kowa, Hisatomo" sort="Kowa, Hisatomo" uniqKey="Kowa H" first="Hisatomo" last="Kowa">Hisatomo Kowa</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Shibahara, Junji" sort="Shibahara, Junji" uniqKey="Shibahara J" first="Junji" last="Shibahara">Junji Shibahara</name>
<affiliation wicri:level="1">
<nlm:aff id="A2">Department of Pathology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Pathology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Nakamura, Koichiro" sort="Nakamura, Koichiro" uniqKey="Nakamura K" first="Koichiro" last="Nakamura">Koichiro Nakamura</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Shimizu, Jun" sort="Shimizu, Jun" uniqKey="Shimizu J" first="Jun" last="Shimizu">Jun Shimizu</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Ugawa, Yoshikazu" sort="Ugawa, Yoshikazu" uniqKey="Ugawa Y" first="Yoshikazu" last="Ugawa">Yoshikazu Ugawa</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Goto, Jun" sort="Goto, Jun" uniqKey="Goto J" first="Jun" last="Goto">Jun Goto</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Dalmau, Josep" sort="Dalmau, Josep" uniqKey="Dalmau J" first="Josep" last="Dalmau">Josep Dalmau</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Neurology (Division Neuro-Oncology), University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology (Division Neuro-Oncology), University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tsuji, Shoji" sort="Tsuji, Shoji" uniqKey="Tsuji S" first="Shoji" last="Tsuji">Shoji Tsuji</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Neurology, The University of Tokyo, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Neurology, The University of Tokyo, Tokyo</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint>
<date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p id="P2">We report a 40-year-old man with severe hypokinesis as paraneoplastic manifestation of a microscopic “carcinoma
<italic>in situ</italic>
” of the testis. The young age of the patient, along with progressive neurologic deterioration, detection of anti-Ma2 antibodies, and ultrasound findings of bilateral microcalcifications, led to bilateral orchiectomy, revealing the tumor in both testes. After orchiectomy, neurological symptoms stabilized, but the patient eventually died of systemic complications caused by his severe neurological deficits. Anti-Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-journal-id">8610688</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5937</journal-id>
<journal-id journal-id-type="nlm-ta">Mov Disord</journal-id>
<journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title>
<issn pub-type="ppub">0885-3185</issn>
<issn pub-type="epub">1531-8257</issn>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">17269131</article-id>
<article-id pub-id-type="pmc">1909751</article-id>
<article-id pub-id-type="doi">10.1002/mds.21314</article-id>
<article-id pub-id-type="manuscript">NIHMS24643</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Severe Hypokinesis Caused by Paraneoplastic Anti-Ma2 Encephalitis Associated with Bilateral Intratubular Germ-Cell Neoplasm of the Testes</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Matsumoto</surname>
<given-names>Lumine</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yamamoto</surname>
<given-names>Tomotaka</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="author-notes" rid="FN1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Higashihara</surname>
<given-names>Mana</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sugimoto</surname>
<given-names>Izumi</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kowa</surname>
<given-names>Hisatomo</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Shibahara</surname>
<given-names>Junji</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nakamura</surname>
<given-names>Koichiro</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Shimizu</surname>
<given-names>Jun</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ugawa</surname>
<given-names>Yoshikazu</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Goto</surname>
<given-names>Jun</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Dalmau</surname>
<given-names>Josep</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tsuji</surname>
<given-names>Shoji</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1">
<label>1</label>
Department of Neurology, The University of Tokyo, Tokyo, Japan</aff>
<aff id="A2">
<label>2</label>
Department of Pathology, The University of Tokyo, Tokyo, Japan</aff>
<aff id="A3">
<label>3</label>
Department of Neurology (Division Neuro-Oncology), University of Pennsylvania, Philadelphia, Pennsylvania, USA</aff>
<author-notes>
<fn fn-type="corresp" id="FN1">
<label>*</label>
<p id="P1">Correspondence to: Tomotaka Yamamoto, MD, PhD, Department of Neurology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-8655, Japan. E-mail:
<email>tyama-tky@umin.ac.jp</email>
</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>12</day>
<month>6</month>
<year>2007</year>
</pub-date>
<pub-date pub-type="ppub">
<day>15</day>
<month>4</month>
<year>2007</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>5</day>
<month>7</month>
<year>2007</year>
</pub-date>
<volume>22</volume>
<issue>5</issue>
<fpage>728</fpage>
<lpage>731</lpage>
<abstract>
<p id="P2">We report a 40-year-old man with severe hypokinesis as paraneoplastic manifestation of a microscopic “carcinoma
<italic>in situ</italic>
” of the testis. The young age of the patient, along with progressive neurologic deterioration, detection of anti-Ma2 antibodies, and ultrasound findings of bilateral microcalcifications, led to bilateral orchiectomy, revealing the tumor in both testes. After orchiectomy, neurological symptoms stabilized, but the patient eventually died of systemic complications caused by his severe neurological deficits. Anti-Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits.</p>
</abstract>
<kwd-group>
<kwd>anti-Ma2 paraneoplastic encephalitis</kwd>
<kwd>hypokinesis</kwd>
<kwd>Parkinsonism</kwd>
<kwd>intratubular germ-cell neoplasia</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000427 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000427 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Pmc
   |étape=   Curation
   |type=    RBID
   |clé=     PMC:1909751
   |texte=   Severe Hypokinesis Caused by Paraneoplastic Anti-Ma2 Encephalitis Associated with Bilateral Intratubular Germ-Cell Neoplasm of the Testes
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i   -Sk "pubmed:17269131" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3 

Wicri

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024