Movement Disorders (revue)

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Severe Hypokinesis Caused by Paraneoplastic Anti-Ma2 Encephalitis Associated with Bilateral Intratubular Germ-Cell Neoplasm of the Testes

Identifieur interne : 000427 ( Pmc/Corpus ); précédent : 000426; suivant : 000428

Severe Hypokinesis Caused by Paraneoplastic Anti-Ma2 Encephalitis Associated with Bilateral Intratubular Germ-Cell Neoplasm of the Testes

Auteurs : Lumine Matsumoto ; Tomotaka Yamamoto ; Mana Higashihara ; Izumi Sugimoto ; Hisatomo Kowa ; Junji Shibahara ; Koichiro Nakamura ; Jun Shimizu ; Yoshikazu Ugawa ; Jun Goto ; Josep Dalmau ; Shoji Tsuji

Source :

RBID : PMC:1909751

Abstract

We report a 40-year-old man with severe hypokinesis as paraneoplastic manifestation of a microscopic “carcinoma in situ” of the testis. The young age of the patient, along with progressive neurologic deterioration, detection of anti-Ma2 antibodies, and ultrasound findings of bilateral microcalcifications, led to bilateral orchiectomy, revealing the tumor in both testes. After orchiectomy, neurological symptoms stabilized, but the patient eventually died of systemic complications caused by his severe neurological deficits. Anti-Ma2 paraneoplastic encephalitis should be considered in patients with severe hypokinesis, and intensive investigation and aggressive approach to treatment is encouraged to prevent progression of the neurological deficits.


Url:
DOI: 10.1002/mds.21314
PubMed: 17269131
PubMed Central: 1909751

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