MovDisordV3, Main, Curation, bibRecord, 004A62

Health‐related quality of life following bilateral intrastriatal transplantation in Parkinson's disease

Identifieur interne : 004A62 ( Main/Curation ); précédent : 004A61; suivant : 004A63

Health‐related quality of life following bilateral intrastriatal transplantation in Parkinson's disease

Auteurs : Peter Hagell [Suède] ; Lesley Crabb [Royaume-Uni] ; Oliver Pogarell [Allemagne] ; Anette Schrag [Royaume-Uni] ; H Kan Widner [Suède] ; David J. Brooks [Royaume-Uni] ; Wolfgang H. Oertel [Allemagne] ; Niall P. Quinn [Royaume-Uni] ; Olle Lindvall [Suède]

Source :

Movement Disorders [ 0885-3185 ] ; 2000-03.

RBID : ISTEX:53517968D8D5C1AA1FD0B61107DB034B33F6B651

Descripteurs français

Pascal (Inist)
- Adulte, Bilatéral, Corps strié, Embryon, Evolution, Homogreffe, Neurone dopaminergique, Nottingham Health Profile, Parkinson maladie, Psychométrie, Qualité vie, Santé, Traitement.
Wicri :
- topic : Adulte.

English descriptors

KwdEn :
- Activities of Daily Living (psychology), Adaptation, Psychological, Adult, Aged, Bilateral, Brain Tissue Transplantation (psychology), Corpus Striatum (surgery), Corpus striatum, Dopaminergic neuron, Embryo, Evolution, Fetal Tissue Transplantation (psychology), Health, Health‐related quality of life, Homograft, Humans, Male, Mesencephalon (transplantation), Middle Aged, Nottingham Health Profile, Parkinson Disease (psychology), Parkinson Disease (surgery), Parkinson disease, Parkinson's disease, Postoperative Complications (psychology), Psychometrics, Quality of Life, Quality of life, Sick Role, Sickness Impact Profile, Transplantation, Treatment.
MESH :
- psychology : Activities of Daily Living, Brain Tissue Transplantation, Fetal Tissue Transplantation, Parkinson Disease, Postoperative Complications.
- surgery : Corpus Striatum, Parkinson Disease.
- transplantation : Mesencephalon.
- Adaptation, Psychological, Adult, Aged, Humans, Male, Middle Aged, Quality of Life, Sick Role, Sickness Impact Profile.

Abstract

Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown long‐term graft survival and therapeutically valuable improvements with decreased l‐dopa dose and time spent in the “off”‐phase, and reduced rigidity and hypokinesia. We have measured health‐related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom‐oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.

Url:

https://api.istex.fr/document/53517968D8D5C1AA1FD0B61107DB034B33F6B651/fulltext/pdf

DOI: 10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001934
to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :001934
to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003262
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :007359
to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002C55
to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :000066
to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002B98
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :007590
to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :004032
to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :004032
to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003F75
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000219
to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000219
to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000219
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :007118

Links to Exploration step

ISTEX:53517968D8D5C1AA1FD0B61107DB034B33F6B651

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Health‐related quality of life following bilateral intrastriatal transplantation in Parkinson's disease</title>
<author><name sortKey="Hagell, Peter" sort="Hagell, Peter" uniqKey="Hagell P" first="Peter" last="Hagell">Peter Hagell</name>
</author>
<author><name sortKey="Crabb, Lesley" sort="Crabb, Lesley" uniqKey="Crabb L" first="Lesley" last="Crabb">Lesley Crabb</name>
</author>
<author><name sortKey="Pogarell, Oliver" sort="Pogarell, Oliver" uniqKey="Pogarell O" first="Oliver" last="Pogarell">Oliver Pogarell</name>
</author>
<author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name>
</author>
<author><name sortKey="Widner, H Kan" sort="Widner, H Kan" uniqKey="Widner H" first="H Kan" last="Widner">H Kan Widner</name>
</author>
<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
</author>
<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name>
</author>
<author><name sortKey="Lindvall, Olle" sort="Lindvall, Olle" uniqKey="Lindvall O" first="Olle" last="Lindvall">Olle Lindvall</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:53517968D8D5C1AA1FD0B61107DB034B33F6B651</idno>
<date when="2000" year="2000">2000</date>
<idno type="doi">10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W</idno>
<idno type="url">https://api.istex.fr/document/53517968D8D5C1AA1FD0B61107DB034B33F6B651/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001934</idno>
<idno type="wicri:Area/Istex/Curation">001934</idno>
<idno type="wicri:Area/Istex/Checkpoint">003262</idno>
<idno type="wicri:doubleKey">0885-3185:2000:Hagell P:health:related:quality</idno>
<idno type="wicri:Area/Main/Merge">007359</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:00-0177299</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002C55</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000066</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002B98</idno>
<idno type="wicri:doubleKey">0885-3185:2000:Hagell P:health:related:quality</idno>
<idno type="wicri:Area/Main/Merge">007590</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:10752570</idno>
<idno type="wicri:Area/PubMed/Corpus">004032</idno>
<idno type="wicri:Area/PubMed/Curation">004032</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003F75</idno>
<idno type="wicri:Area/Ncbi/Merge">000219</idno>
<idno type="wicri:Area/Ncbi/Curation">000219</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000219</idno>
<idno type="wicri:doubleKey">0885-3185:2000:Hagell P:health:related:quality</idno>
<idno type="wicri:Area/Main/Merge">007118</idno>
<idno type="wicri:Area/Main/Curation">004A62</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Health‐related quality of life following bilateral intrastriatal transplantation in Parkinson's disease</title>
<author><name sortKey="Hagell, Peter" sort="Hagell, Peter" uniqKey="Hagell P" first="Peter" last="Hagell">Peter Hagell</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Section of Restorative Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Crabb, Lesley" sort="Crabb, Lesley" uniqKey="Crabb L" first="Lesley" last="Crabb">Lesley Crabb</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Neurology, Queen Square, Hammersmith Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pogarell, Oliver" sort="Pogarell, Oliver" uniqKey="Pogarell O" first="Oliver" last="Pogarell">Oliver Pogarell</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Center of Nervous Diseases, Philipps‐University Marburg, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Neurology, Queen Square, Hammersmith Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Widner, H Kan" sort="Widner, H Kan" uniqKey="Widner H" first="H Kan" last="Widner">H Kan Widner</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Neurobiology, Department of Physiological Sciences, University of Lund, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Cyclotron Unit, Hammersmith Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Center of Nervous Diseases, Philipps‐University Marburg, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Neurology, Queen Square, Hammersmith Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lindvall, Olle" sort="Lindvall, Olle" uniqKey="Lindvall O" first="Olle" last="Lindvall">Olle Lindvall</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Section of Restorative Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>John Wiley & Sons, Inc.</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2000-03">2000-03</date>
<biblScope unit="vol">15</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="224">224</biblScope>
<biblScope unit="page" to="229">229</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">53517968D8D5C1AA1FD0B61107DB034B33F6B651</idno>
<idno type="DOI">10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W</idno>
<idno type="ArticleID">MDS1004</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living (psychology)</term>
<term>Adaptation, Psychological</term>
<term>Adult</term>
<term>Aged</term>
<term>Bilateral</term>
<term>Brain Tissue Transplantation (psychology)</term>
<term>Corpus Striatum (surgery)</term>
<term>Corpus striatum</term>
<term>Dopaminergic neuron</term>
<term>Embryo</term>
<term>Evolution</term>
<term>Fetal Tissue Transplantation (psychology)</term>
<term>Health</term>
<term>Health‐related quality of life</term>
<term>Homograft</term>
<term>Humans</term>
<term>Male</term>
<term>Mesencephalon (transplantation)</term>
<term>Middle Aged</term>
<term>Nottingham Health Profile</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Postoperative Complications (psychology)</term>
<term>Psychometrics</term>
<term>Quality of Life</term>
<term>Quality of life</term>
<term>Sick Role</term>
<term>Sickness Impact Profile</term>
<term>Transplantation</term>
<term>Treatment</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Activities of Daily Living</term>
<term>Brain Tissue Transplantation</term>
<term>Fetal Tissue Transplantation</term>
<term>Parkinson Disease</term>
<term>Postoperative Complications</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Corpus Striatum</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Mesencephalon</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adaptation, Psychological</term>
<term>Adult</term>
<term>Aged</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Quality of Life</term>
<term>Sick Role</term>
<term>Sickness Impact Profile</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term>
<term>Bilatéral</term>
<term>Corps strié</term>
<term>Embryon</term>
<term>Evolution</term>
<term>Homogreffe</term>
<term>Neurone dopaminergique</term>
<term>Nottingham Health Profile</term>
<term>Parkinson maladie</term>
<term>Psychométrie</term>
<term>Qualité vie</term>
<term>Santé</term>
<term>Traitement</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown long‐term graft survival and therapeutically valuable improvements with decreased l‐dopa dose and time spent in the “off”‐phase, and reduced rigidity and hypokinesia. We have measured health‐related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom‐oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.</div>
</front>
</TEI>
<double idat="0885-3185:2000:Hagell P:health:related:quality"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease</title>
<author><name sortKey="Hagell, P" sort="Hagell, P" uniqKey="Hagell P" first="P." last="Hagell">P. Hagell</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Restorative Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Crabb, L" sort="Crabb, L" uniqKey="Crabb L" first="L." last="Crabb">L. Crabb</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Neurology, Queen Square, Hammersmith Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pogarell, O" sort="Pogarell, O" uniqKey="Pogarell O" first="O." last="Pogarell">O. Pogarell</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurology, Center of Nervous Diseases, Philipps-University Marburg</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schrag, A" sort="Schrag, A" uniqKey="Schrag A" first="A." last="Schrag">A. Schrag</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Neurology, Queen Square, Hammersmith Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Widner, H" sort="Widner, H" uniqKey="Widner H" first="H." last="Widner">H. Widner</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Division of Neurobiology, Department of Physiological Sciences, University of Lund</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brooks, D J" sort="Brooks, D J" uniqKey="Brooks D" first="D. J." last="Brooks">D. J. Brooks</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>MRC Cyclotron Unit, Hammersmith Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W. H." last="Oertel">W. H. Oertel</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurology, Center of Nervous Diseases, Philipps-University Marburg</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N. P." last="Quinn">N. P. Quinn</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Neurology, Queen Square, Hammersmith Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lindvall, O" sort="Lindvall, O" uniqKey="Lindvall O" first="O." last="Lindvall">O. Lindvall</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Restorative Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">00-0177299</idno>
<date when="2000">2000</date>
<idno type="stanalyst">PASCAL 00-0177299 INIST</idno>
<idno type="RBID">Pascal:00-0177299</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002C55</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000066</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002B98</idno>
<idno type="wicri:doubleKey">0885-3185:2000:Hagell P:health:related:quality</idno>
<idno type="wicri:Area/Main/Merge">007590</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease</title>
<author><name sortKey="Hagell, P" sort="Hagell, P" uniqKey="Hagell P" first="P." last="Hagell">P. Hagell</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Restorative Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Crabb, L" sort="Crabb, L" uniqKey="Crabb L" first="L." last="Crabb">L. Crabb</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Neurology, Queen Square, Hammersmith Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pogarell, O" sort="Pogarell, O" uniqKey="Pogarell O" first="O." last="Pogarell">O. Pogarell</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurology, Center of Nervous Diseases, Philipps-University Marburg</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schrag, A" sort="Schrag, A" uniqKey="Schrag A" first="A." last="Schrag">A. Schrag</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Neurology, Queen Square, Hammersmith Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Widner, H" sort="Widner, H" uniqKey="Widner H" first="H." last="Widner">H. Widner</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Division of Neurobiology, Department of Physiological Sciences, University of Lund</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brooks, D J" sort="Brooks, D J" uniqKey="Brooks D" first="D. J." last="Brooks">D. J. Brooks</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>MRC Cyclotron Unit, Hammersmith Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W. H." last="Oertel">W. H. Oertel</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurology, Center of Nervous Diseases, Philipps-University Marburg</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N. P." last="Quinn">N. P. Quinn</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Neurology, Queen Square, Hammersmith Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lindvall, O" sort="Lindvall, O" uniqKey="Lindvall O" first="O." last="Lindvall">O. Lindvall</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Restorative Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2000">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Bilateral</term>
<term>Corpus striatum</term>
<term>Dopaminergic neuron</term>
<term>Embryo</term>
<term>Evolution</term>
<term>Health</term>
<term>Homograft</term>
<term>Nottingham Health Profile</term>
<term>Parkinson disease</term>
<term>Psychometrics</term>
<term>Quality of life</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Qualité vie</term>
<term>Santé</term>
<term>Homogreffe</term>
<term>Neurone dopaminergique</term>
<term>Embryon</term>
<term>Corps strié</term>
<term>Bilatéral</term>
<term>Nottingham Health Profile</term>
<term>Traitement</term>
<term>Evolution</term>
<term>Psychométrie</term>
<term>Adulte</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown long-term graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Health‐related quality of life following bilateral intrastriatal transplantation in Parkinson's disease</title>
<author><name sortKey="Hagell, Peter" sort="Hagell, Peter" uniqKey="Hagell P" first="Peter" last="Hagell">Peter Hagell</name>
</author>
<author><name sortKey="Crabb, Lesley" sort="Crabb, Lesley" uniqKey="Crabb L" first="Lesley" last="Crabb">Lesley Crabb</name>
</author>
<author><name sortKey="Pogarell, Oliver" sort="Pogarell, Oliver" uniqKey="Pogarell O" first="Oliver" last="Pogarell">Oliver Pogarell</name>
</author>
<author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name>
</author>
<author><name sortKey="Widner, H Kan" sort="Widner, H Kan" uniqKey="Widner H" first="H Kan" last="Widner">H Kan Widner</name>
</author>
<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
</author>
<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name>
</author>
<author><name sortKey="Lindvall, Olle" sort="Lindvall, Olle" uniqKey="Lindvall O" first="Olle" last="Lindvall">Olle Lindvall</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:53517968D8D5C1AA1FD0B61107DB034B33F6B651</idno>
<date when="2000" year="2000">2000</date>
<idno type="doi">10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W</idno>
<idno type="url">https://api.istex.fr/document/53517968D8D5C1AA1FD0B61107DB034B33F6B651/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001934</idno>
<idno type="wicri:Area/Istex/Curation">001934</idno>
<idno type="wicri:Area/Istex/Checkpoint">003262</idno>
<idno type="wicri:doubleKey">0885-3185:2000:Hagell P:health:related:quality</idno>
<idno type="wicri:Area/Main/Merge">007359</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Health‐related quality of life following bilateral intrastriatal transplantation in Parkinson's disease</title>
<author><name sortKey="Hagell, Peter" sort="Hagell, Peter" uniqKey="Hagell P" first="Peter" last="Hagell">Peter Hagell</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Section of Restorative Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Crabb, Lesley" sort="Crabb, Lesley" uniqKey="Crabb L" first="Lesley" last="Crabb">Lesley Crabb</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Neurology, Queen Square, Hammersmith Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pogarell, Oliver" sort="Pogarell, Oliver" uniqKey="Pogarell O" first="Oliver" last="Pogarell">Oliver Pogarell</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Center of Nervous Diseases, Philipps‐University Marburg, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Neurology, Queen Square, Hammersmith Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Widner, H Kan" sort="Widner, H Kan" uniqKey="Widner H" first="H Kan" last="Widner">H Kan Widner</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Neurobiology, Department of Physiological Sciences, University of Lund, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David J." last="Brooks">David J. Brooks</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Cyclotron Unit, Hammersmith Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oertel, Wolfgang H" sort="Oertel, Wolfgang H" uniqKey="Oertel W" first="Wolfgang H." last="Oertel">Wolfgang H. Oertel</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, Center of Nervous Diseases, Philipps‐University Marburg, Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Neurology, Queen Square, Hammersmith Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lindvall, Olle" sort="Lindvall, Olle" uniqKey="Lindvall O" first="Olle" last="Lindvall">Olle Lindvall</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Section of Restorative Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>John Wiley & Sons, Inc.</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2000-03">2000-03</date>
<biblScope unit="vol">15</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="224">224</biblScope>
<biblScope unit="page" to="229">229</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">53517968D8D5C1AA1FD0B61107DB034B33F6B651</idno>
<idno type="DOI">10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W</idno>
<idno type="ArticleID">MDS1004</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Health‐related quality of life</term>
<term>Nottingham Health Profile</term>
<term>Parkinson's disease</term>
<term>Transplantation</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown long‐term graft survival and therapeutically valuable improvements with decreased l‐dopa dose and time spent in the “off”‐phase, and reduced rigidity and hypokinesia. We have measured health‐related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom‐oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.</div>
</front>
</TEI>
</ISTEX>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease.</title>
<author><name sortKey="Hagell, P" sort="Hagell, P" uniqKey="Hagell P" first="P" last="Hagell">P. Hagell</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Neuroscience, University Hospital, University of Lund, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Clinical Neuroscience, University Hospital, University of Lund</wicri:regionArea>
<wicri:noRegion>University of Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Crabb, L" sort="Crabb, L" uniqKey="Crabb L" first="L" last="Crabb">L. Crabb</name>
</author>
<author><name sortKey="Pogarell, O" sort="Pogarell, O" uniqKey="Pogarell O" first="O" last="Pogarell">O. Pogarell</name>
</author>
<author><name sortKey="Schrag, A" sort="Schrag, A" uniqKey="Schrag A" first="A" last="Schrag">A. Schrag</name>
</author>
<author><name sortKey="Widner, H" sort="Widner, H" uniqKey="Widner H" first="H" last="Widner">H. Widner</name>
</author>
<author><name sortKey="Brooks, D J" sort="Brooks, D J" uniqKey="Brooks D" first="D J" last="Brooks">D J Brooks</name>
</author>
<author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W H" last="Oertel">W H Oertel</name>
</author>
<author><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N P" last="Quinn">N P Quinn</name>
</author>
<author><name sortKey="Lindvall, O" sort="Lindvall, O" uniqKey="Lindvall O" first="O" last="Lindvall">O. Lindvall</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2000">2000</date>
<idno type="RBID">pubmed:10752570</idno>
<idno type="pmid">10752570</idno>
<idno type="wicri:Area/PubMed/Corpus">004032</idno>
<idno type="wicri:Area/PubMed/Curation">004032</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003F75</idno>
<idno type="wicri:Area/Ncbi/Merge">000219</idno>
<idno type="wicri:Area/Ncbi/Curation">000219</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000219</idno>
<idno type="wicri:doubleKey">0885-3185:2000:Hagell P:health:related:quality</idno>
<idno type="wicri:Area/Main/Merge">007118</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease.</title>
<author><name sortKey="Hagell, P" sort="Hagell, P" uniqKey="Hagell P" first="P" last="Hagell">P. Hagell</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Neuroscience, University Hospital, University of Lund, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Clinical Neuroscience, University Hospital, University of Lund</wicri:regionArea>
<wicri:noRegion>University of Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Crabb, L" sort="Crabb, L" uniqKey="Crabb L" first="L" last="Crabb">L. Crabb</name>
</author>
<author><name sortKey="Pogarell, O" sort="Pogarell, O" uniqKey="Pogarell O" first="O" last="Pogarell">O. Pogarell</name>
</author>
<author><name sortKey="Schrag, A" sort="Schrag, A" uniqKey="Schrag A" first="A" last="Schrag">A. Schrag</name>
</author>
<author><name sortKey="Widner, H" sort="Widner, H" uniqKey="Widner H" first="H" last="Widner">H. Widner</name>
</author>
<author><name sortKey="Brooks, D J" sort="Brooks, D J" uniqKey="Brooks D" first="D J" last="Brooks">D J Brooks</name>
</author>
<author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W H" last="Oertel">W H Oertel</name>
</author>
<author><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N P" last="Quinn">N P Quinn</name>
</author>
<author><name sortKey="Lindvall, O" sort="Lindvall, O" uniqKey="Lindvall O" first="O" last="Lindvall">O. Lindvall</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2000" type="published">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living (psychology)</term>
<term>Adaptation, Psychological</term>
<term>Adult</term>
<term>Aged</term>
<term>Brain Tissue Transplantation (psychology)</term>
<term>Corpus Striatum (surgery)</term>
<term>Fetal Tissue Transplantation (psychology)</term>
<term>Humans</term>
<term>Male</term>
<term>Mesencephalon (transplantation)</term>
<term>Middle Aged</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Postoperative Complications (psychology)</term>
<term>Quality of Life</term>
<term>Sick Role</term>
<term>Sickness Impact Profile</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Activities of Daily Living</term>
<term>Brain Tissue Transplantation</term>
<term>Fetal Tissue Transplantation</term>
<term>Parkinson Disease</term>
<term>Postoperative Complications</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Corpus Striatum</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Mesencephalon</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adaptation, Psychological</term>
<term>Adult</term>
<term>Aged</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Quality of Life</term>
<term>Sick Role</term>
<term>Sickness Impact Profile</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown longterm graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.</div>
</front>
</TEI>
</PubMed>
</double>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004A62 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 004A62 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Curation
   |type=    RBID
   |clé=     ISTEX:53517968D8D5C1AA1FD0B61107DB034B33F6B651
   |texte=   Health‐related quality of life following bilateral intrastriatal transplantation in Parkinson's disease
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Health‐related quality of life following bilateral intrastriatal transplantation in Parkinson's disease

Health‐related quality of life following bilateral intrastriatal transplantation in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri