Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease
Identifieur interne : 002B98 ( PascalFrancis/Checkpoint ); précédent : 002B97; suivant : 002B99Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease
Auteurs : P. Hagell [Suède] ; L. Crabb [Royaume-Uni] ; O. Pogarell [Allemagne] ; A. Schrag [Royaume-Uni] ; H. Widner [Suède] ; D. J. Brooks [Royaume-Uni] ; W. H. Oertel [Allemagne] ; N. P. Quinn [Royaume-Uni] ; O. Lindvall [Suède]Source :
- Movement disorders [ 0885-3185 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
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Abstract
Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown long-term graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.
Affiliations:
- Allemagne, Royaume-Uni, Suède
- Angleterre, District de Giessen, Grand Londres, Hesse (Land)
- Londres, Marbourg
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Hagell</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Restorative Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Crabb, L" sort="Crabb, L" uniqKey="Crabb L" first="L." last="Crabb">L. 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Oertel</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurology, Center of Nervous Diseases, Philipps-University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N. P." last="Quinn">N. P. Quinn</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Neurology, Queen Square, Hammersmith Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lindvall, O" sort="Lindvall, O" uniqKey="Lindvall O" first="O." last="Lindvall">O. Lindvall</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Restorative Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">00-0177299</idno><date when="2000">2000</date><idno type="stanalyst">PASCAL 00-0177299 INIST</idno><idno type="RBID">Pascal:00-0177299</idno><idno type="wicri:Area/PascalFrancis/Corpus">002C55</idno><idno type="wicri:Area/PascalFrancis/Curation">000066</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002B98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease</title><author><name sortKey="Hagell, P" sort="Hagell, P" uniqKey="Hagell P" first="P." last="Hagell">P. Hagell</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Restorative Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Crabb, L" sort="Crabb, L" uniqKey="Crabb L" first="L." last="Crabb">L. Crabb</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Neurology, Queen Square, Hammersmith Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pogarell, O" sort="Pogarell, O" uniqKey="Pogarell O" first="O." last="Pogarell">O. Pogarell</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurology, Center of Nervous Diseases, Philipps-University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Schrag, A" sort="Schrag, A" uniqKey="Schrag A" first="A." last="Schrag">A. Schrag</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Neurology, Queen Square, Hammersmith Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Widner, H" sort="Widner, H" uniqKey="Widner H" first="H." last="Widner">H. Widner</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Division of Neurobiology, Department of Physiological Sciences, University of Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>5 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Brooks, D J" sort="Brooks, D J" uniqKey="Brooks D" first="D. J." last="Brooks">D. J. Brooks</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>MRC Cyclotron Unit, Hammersmith Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W. H." last="Oertel">W. H. Oertel</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurology, Center of Nervous Diseases, Philipps-University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N. P." last="Quinn">N. P. Quinn</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Neurology, Queen Square, Hammersmith Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lindvall, O" sort="Lindvall, O" uniqKey="Lindvall O" first="O." last="Lindvall">O. Lindvall</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Restorative Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Lund</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Bilateral</term><term>Corpus striatum</term><term>Dopaminergic neuron</term><term>Embryo</term><term>Evolution</term><term>Health</term><term>Homograft</term><term>Nottingham Health Profile</term><term>Parkinson disease</term><term>Psychometrics</term><term>Quality of life</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Qualité vie</term><term>Santé</term><term>Homogreffe</term><term>Neurone dopaminergique</term><term>Embryon</term><term>Corps strié</term><term>Bilatéral</term><term>Nottingham Health Profile</term><term>Traitement</term><term>Evolution</term><term>Psychométrie</term><term>Adulte</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown long-term graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>15</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease</s1></fA08><fA11 i1="01" i2="1"><s1>HAGELL (P.)</s1></fA11><fA11 i1="02" i2="1"><s1>CRABB (L.)</s1></fA11><fA11 i1="03" i2="1"><s1>POGARELL (O.)</s1></fA11><fA11 i1="04" i2="1"><s1>SCHRAG (A.)</s1></fA11><fA11 i1="05" i2="1"><s1>WIDNER (H.)</s1></fA11><fA11 i1="06" i2="1"><s1>BROOKS (D. J.)</s1></fA11><fA11 i1="07" i2="1"><s1>OERTEL (W. H.)</s1></fA11><fA11 i1="08" i2="1"><s1>QUINN (N. P.)</s1></fA11><fA11 i1="09" i2="1"><s1>LINDVALL (O.)</s1></fA11><fA14 i1="01"><s1>Section of Restorative Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>9 aut.</sZ></fA14><fA14 i1="02"><s1>Division of Neurology, Department of Clinical Neuroscience, University Hospital, University of Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></fA14><fA14 i1="03"><s1>Institute of Neurology, Queen Square, Hammersmith Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Neurology, Center of Nervous Diseases, Philipps-University Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="05"><s1>Division of Neurobiology, Department of Physiological Sciences, University of Lund</s1><s2>Lund</s2><s3>SWE</s3><sZ>5 aut.</sZ></fA14><fA14 i1="06"><s1>MRC Cyclotron Unit, Hammersmith Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>6 aut.</sZ></fA14><fA20><s1>224-229</s1></fA20><fA21><s1>2000</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000082110890040</s5></fA43><fA44><s0>0000</s0><s1>© 2000 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>47 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>00-0177299</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown long-term graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.</s0></fC01><fC02 i1="01" i2="X"><s0>002B25J01</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Qualité vie</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Quality of life</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Calidad vida</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Santé</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Health</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Salud</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Homogreffe</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Homograft</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Homoinjerto</s0><s5>07</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Neurone dopaminergique</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Dopaminergic neuron</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Neurona dopaminérgica</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Embryon</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Embryo</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Embrión</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Corps strié</s0><s5>10</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Corpus striatum</s0><s5>10</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Cuerpo estriado</s0><s5>10</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Bilatéral</s0><s5>11</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Bilateral</s0><s5>11</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Bilateral</s0><s5>11</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Nottingham Health Profile</s0><s2>NP</s2><s5>13</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Nottingham Health Profile</s0><s2>NP</s2><s5>13</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Nottingham Health Profile</s0><s2>NP</s2><s5>13</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Traitement</s0><s5>17</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Treatment</s0><s5>17</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Tratamiento</s0><s5>17</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Evolution</s0><s5>18</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Evolution</s0><s5>18</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Evolución</s0><s5>18</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Psychométrie</s0><s5>19</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Psychometrics</s0><s5>19</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Psicometría</s0><s5>19</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Adulte</s0><s5>20</s5></fC03><fC03 i1="13" i2="X" l="ENG"><s0>Adult</s0><s5>20</s5></fC03><fC03 i1="13" i2="X" l="SPA"><s0>Adulto</s0><s5>20</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Human</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>37</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>38</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>39</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>40</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>41</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Greffe</s0><s5>53</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Graft</s0><s5>53</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Injerto</s0><s5>53</s5></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Chirurgie</s0><s5>54</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Surgery</s0><s5>54</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Cirugía</s0><s5>54</s5></fC07><fN21><s1>129</s1></fN21></pA></standard></inist><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li><li>Suède</li></country><region><li>Angleterre</li><li>District de Giessen</li><li>Grand Londres</li><li>Hesse (Land)</li></region><settlement><li>Londres</li><li>Marbourg</li></settlement></list><tree><country name="Suède"><noRegion><name sortKey="Hagell, P" sort="Hagell, P" uniqKey="Hagell P" first="P." last="Hagell">P. Hagell</name></noRegion><name sortKey="Hagell, P" sort="Hagell, P" uniqKey="Hagell P" first="P." last="Hagell">P. Hagell</name><name sortKey="Lindvall, O" sort="Lindvall, O" uniqKey="Lindvall O" first="O." last="Lindvall">O. Lindvall</name><name sortKey="Lindvall, O" sort="Lindvall, O" uniqKey="Lindvall O" first="O." last="Lindvall">O. Lindvall</name><name sortKey="Widner, H" sort="Widner, H" uniqKey="Widner H" first="H." last="Widner">H. Widner</name><name sortKey="Widner, H" sort="Widner, H" uniqKey="Widner H" first="H." last="Widner">H. Widner</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Crabb, L" sort="Crabb, L" uniqKey="Crabb L" first="L." last="Crabb">L. Crabb</name></region><name sortKey="Brooks, D J" sort="Brooks, D J" uniqKey="Brooks D" first="D. J." last="Brooks">D. J. Brooks</name><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N. P." last="Quinn">N. P. Quinn</name><name sortKey="Schrag, A" sort="Schrag, A" uniqKey="Schrag A" first="A." last="Schrag">A. Schrag</name></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Pogarell, O" sort="Pogarell, O" uniqKey="Pogarell O" first="O." last="Pogarell">O. Pogarell</name></region><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W. H." last="Oertel">W. H. Oertel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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