Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease.
Identifieur interne : 000219 ( Ncbi/Checkpoint ); précédent : 000218; suivant : 000220Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease.
Auteurs : P. Hagell [Suède] ; L. Crabb ; O. Pogarell ; A. Schrag ; H. Widner ; D J Brooks ; W H Oertel ; N P Quinn ; O. LindvallSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2000.
English descriptors
- KwdEn :
- Activities of Daily Living (psychology), Adaptation, Psychological, Adult, Aged, Brain Tissue Transplantation (psychology), Corpus Striatum (surgery), Fetal Tissue Transplantation (psychology), Humans, Male, Mesencephalon (transplantation), Middle Aged, Parkinson Disease (psychology), Parkinson Disease (surgery), Postoperative Complications (psychology), Quality of Life, Sick Role, Sickness Impact Profile.
- MESH :
- psychology : Activities of Daily Living, Brain Tissue Transplantation, Fetal Tissue Transplantation, Parkinson Disease, Postoperative Complications.
- surgery : Corpus Striatum, Parkinson Disease.
- transplantation : Mesencephalon.
- Adaptation, Psychological, Adult, Aged, Humans, Male, Middle Aged, Quality of Life, Sick Role, Sickness Impact Profile.
Abstract
Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown longterm graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.
PubMed: 10752570
Affiliations:
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Pogarell</name></author><author><name sortKey="Schrag, A" sort="Schrag, A" uniqKey="Schrag A" first="A" last="Schrag">A. Schrag</name></author><author><name sortKey="Widner, H" sort="Widner, H" uniqKey="Widner H" first="H" last="Widner">H. Widner</name></author><author><name sortKey="Brooks, D J" sort="Brooks, D J" uniqKey="Brooks D" first="D J" last="Brooks">D J Brooks</name></author><author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W H" last="Oertel">W H Oertel</name></author><author><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N P" last="Quinn">N P Quinn</name></author><author><name sortKey="Lindvall, O" sort="Lindvall, O" uniqKey="Lindvall O" first="O" last="Lindvall">O. Lindvall</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2000">2000</date><idno type="RBID">pubmed:10752570</idno><idno type="pmid">10752570</idno><idno type="wicri:Area/PubMed/Corpus">004032</idno><idno type="wicri:Area/PubMed/Curation">004032</idno><idno type="wicri:Area/PubMed/Checkpoint">003F75</idno><idno type="wicri:Area/Ncbi/Merge">000219</idno><idno type="wicri:Area/Ncbi/Curation">000219</idno><idno type="wicri:Area/Ncbi/Checkpoint">000219</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease.</title><author><name sortKey="Hagell, P" sort="Hagell, P" uniqKey="Hagell P" first="P" last="Hagell">P. Hagell</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Neuroscience, University Hospital, University of Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Neuroscience, University Hospital, University of Lund</wicri:regionArea><wicri:noRegion>University of Lund</wicri:noRegion></affiliation></author><author><name sortKey="Crabb, L" sort="Crabb, L" uniqKey="Crabb L" first="L" last="Crabb">L. Crabb</name></author><author><name sortKey="Pogarell, O" sort="Pogarell, O" uniqKey="Pogarell O" first="O" last="Pogarell">O. Pogarell</name></author><author><name sortKey="Schrag, A" sort="Schrag, A" uniqKey="Schrag A" first="A" last="Schrag">A. Schrag</name></author><author><name sortKey="Widner, H" sort="Widner, H" uniqKey="Widner H" first="H" last="Widner">H. Widner</name></author><author><name sortKey="Brooks, D J" sort="Brooks, D J" uniqKey="Brooks D" first="D J" last="Brooks">D J Brooks</name></author><author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W H" last="Oertel">W H Oertel</name></author><author><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N P" last="Quinn">N P Quinn</name></author><author><name sortKey="Lindvall, O" sort="Lindvall, O" uniqKey="Lindvall O" first="O" last="Lindvall">O. Lindvall</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living (psychology)</term><term>Adaptation, Psychological</term><term>Adult</term><term>Aged</term><term>Brain Tissue Transplantation (psychology)</term><term>Corpus Striatum (surgery)</term><term>Fetal Tissue Transplantation (psychology)</term><term>Humans</term><term>Male</term><term>Mesencephalon (transplantation)</term><term>Middle Aged</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (surgery)</term><term>Postoperative Complications (psychology)</term><term>Quality of Life</term><term>Sick Role</term><term>Sickness Impact Profile</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Activities of Daily Living</term><term>Brain Tissue Transplantation</term><term>Fetal Tissue Transplantation</term><term>Parkinson Disease</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Mesencephalon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptation, Psychological</term><term>Adult</term><term>Aged</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Quality of Life</term><term>Sick Role</term><term>Sickness Impact Profile</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown longterm graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.</div></front></TEI><affiliations><list><country><li>Suède</li></country></list><tree><noCountry><name sortKey="Brooks, D J" sort="Brooks, D J" uniqKey="Brooks D" first="D J" last="Brooks">D J Brooks</name><name sortKey="Crabb, L" sort="Crabb, L" uniqKey="Crabb L" first="L" last="Crabb">L. Crabb</name><name sortKey="Lindvall, O" sort="Lindvall, O" uniqKey="Lindvall O" first="O" last="Lindvall">O. Lindvall</name><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W H" last="Oertel">W H Oertel</name><name sortKey="Pogarell, O" sort="Pogarell, O" uniqKey="Pogarell O" first="O" last="Pogarell">O. Pogarell</name><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N P" last="Quinn">N P Quinn</name><name sortKey="Schrag, A" sort="Schrag, A" uniqKey="Schrag A" first="A" last="Schrag">A. Schrag</name><name sortKey="Widner, H" sort="Widner, H" uniqKey="Widner H" first="H" last="Widner">H. Widner</name></noCountry><country name="Suède"><noRegion><name sortKey="Hagell, P" sort="Hagell, P" uniqKey="Hagell P" first="P" last="Hagell">P. Hagell</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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