Health‐related quality of life following bilateral intrastriatal transplantation in Parkinson's disease
Identifieur interne : 001934 ( Istex/Curation ); précédent : 001933; suivant : 001935Health‐related quality of life following bilateral intrastriatal transplantation in Parkinson's disease
Auteurs : Peter Hagell [Suède] ; Lesley Crabb [Royaume-Uni] ; Oliver Pogarell [Allemagne] ; Anette Schrag [Royaume-Uni] ; H Kan Widner [Suède] ; David J. Brooks [Royaume-Uni] ; Wolfgang H. Oertel [Allemagne] ; Niall P. Quinn [Royaume-Uni] ; Olle Lindvall [Suède]Source :
- Movement Disorders [ 0885-3185 ] ; 2000-03.
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Abstract
Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown long‐term graft survival and therapeutically valuable improvements with decreased l‐dopa dose and time spent in the “off”‐phase, and reduced rigidity and hypokinesia. We have measured health‐related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom‐oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.
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DOI: 10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-03">2000-03</date><biblScope unit="vol">15</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="224">224</biblScope><biblScope unit="page" to="229">229</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">53517968D8D5C1AA1FD0B61107DB034B33F6B651</idno><idno type="DOI">10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W</idno><idno type="ArticleID">MDS1004</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Health‐related quality of life</term><term>Nottingham Health Profile</term><term>Parkinson's disease</term><term>Transplantation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown long‐term graft survival and therapeutically valuable improvements with decreased l‐dopa dose and time spent in the “off”‐phase, and reduced rigidity and hypokinesia. We have measured health‐related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom‐oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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