MovDisordV3, PascalFrancis, Curation, bibRecord, 000066

Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease

Identifieur interne : 000066 ( PascalFrancis/Curation ); précédent : 000065; suivant : 000067

Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease

Auteurs : P. Hagell [Suède] ; L. Crabb [Royaume-Uni] ; O. Pogarell [Allemagne] ; A. Schrag [Royaume-Uni] ; H. Widner [Suède] ; D. J. Brooks [Royaume-Uni] ; W. H. Oertel [Allemagne] ; N. P. Quinn [Royaume-Uni] ; O. Lindvall [Suède]

Source :

Movement disorders [ 0885-3185 ] ; 2000.

RBID : Pascal:00-0177299

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Qualité vie, Santé, Homogreffe, Neurone dopaminergique, Embryon, Corps strié, Bilatéral, Nottingham Health Profile, Traitement, Evolution, Psychométrie, Adulte.
Wicri :
- topic : Adulte.

English descriptors

KwdEn :
- Adult, Bilateral, Corpus striatum, Dopaminergic neuron, Embryo, Evolution, Health, Homograft, Nottingham Health Profile, Parkinson disease, Psychometrics, Quality of life, Treatment.

Abstract

Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown long-term graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.

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A08	`01`	`1`	`ENG`	`@1 Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease`
A11	`01`	`1`		`@1 HAGELL (P.)`
A11	`02`	`1`		`@1 CRABB (L.)`
A11	`03`	`1`		`@1 POGARELL (O.)`
A11	`04`	`1`		`@1 SCHRAG (A.)`
A11	`05`	`1`		`@1 WIDNER (H.)`
A11	`06`	`1`		`@1 BROOKS (D. J.)`
A11	`07`	`1`		`@1 OERTEL (W. H.)`
A11	`08`	`1`		`@1 QUINN (N. P.)`
A11	`09`	`1`		`@1 LINDVALL (O.)`
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A14	`04`			`@1 Department of Neurology, Center of Nervous Diseases, Philipps-University Marburg @2 Marburg @3 DEU @Z 3 aut. @Z 7 aut.`
A14	`05`			`@1 Division of Neurobiology, Department of Physiological Sciences, University of Lund @2 Lund @3 SWE @Z 5 aut.`
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C01	`01`		`ENG`	@0 Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown long-term graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.
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C03	`08`	`X`	`FRE`	`@0 Bilatéral @5 11`
C03	`08`	`X`	`ENG`	`@0 Bilateral @5 11`
C03	`08`	`X`	`SPA`	`@0 Bilateral @5 11`
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C03	`10`	`X`	`FRE`	`@0 Traitement @5 17`
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C07	`01`	`X`	`FRE`	`@0 Homme`
C07	`01`	`X`	`ENG`	`@0 Human`
C07	`01`	`X`	`SPA`	`@0 Hombre`
C07	`02`	`X`	`FRE`	`@0 Système nerveux pathologie @5 37`
C07	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 37`
C07	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 37`
C07	`03`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 38`
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C07	`06`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
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C07	`06`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
C07	`07`	`X`	`FRE`	`@0 Greffe @5 53`
C07	`07`	`X`	`ENG`	`@0 Graft @5 53`
C07	`07`	`X`	`SPA`	`@0 Injerto @5 53`
C07	`08`	`X`	`FRE`	`@0 Chirurgie @5 54`
C07	`08`	`X`	`ENG`	`@0 Surgery @5 54`
C07	`08`	`X`	`SPA`	`@0 Cirugía @5 54`
N21				`@1 129`

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Bilateral</term>
<term>Corpus striatum</term>
<term>Dopaminergic neuron</term>
<term>Embryo</term>
<term>Evolution</term>
<term>Health</term>
<term>Homograft</term>
<term>Nottingham Health Profile</term>
<term>Parkinson disease</term>
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<front><div type="abstract" xml:lang="en">Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown long-term graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.</div>
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<fC01 i1="01" l="ENG"><s0>Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown long-term graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.</s0>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease

Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease

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