MovDisordV3, Main, Curation, bibRecord, 004708

Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease

Identifieur interne : 004708 ( Main/Curation ); précédent : 004707; suivant : 004709

Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease

Auteurs : J. P. P. Van Vugt [Pays-Bas] ; S. Siesling [Pays-Bas] ; K. K. E. Piet [Pays-Bas] ; A. H. Zwinderman [Pays-Bas] ; H. A. M. Middelkoop [Pays-Bas] ; J. J. Van Hilten [Pays-Bas] ; R. A. C. Roos [Pays-Bas]

Source :

Movement Disorders [ 0885-3185 ] ; 2001-05.

RBID : ISTEX:4B43B65CA0E4E157DA9E42D3E6F580153F58163A

Descripteurs français

Pascal (Inist)
- Activité manuelle, Chorée Huntington, Handicap moteur, Homme, Jour, Pronostic.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Aged, Case-Control Studies, Circadian Rhythm, Day, Disease Progression, Female, Follow-Up Studies, Human, Humans, Huntington Disease (complications), Huntington Disease (physiopathology), Huntington disease, Huntington's disease, Hypokinesia (etiology), Hypokinesia (physiopathology), Male, Manual activity, Middle Aged, Monitoring, Ambulatory (methods), Motor Activity, Motor handicap, Predictive Value of Tests, Prognosis, activity monitoring, follow‐up, functional capacity, voluntary movement.
MESH :
- complications : Huntington Disease.
- etiology : Hypokinesia.
- methods : Monitoring, Ambulatory.
- physiopathology : Huntington Disease, Hypokinesia.
- Adult, Aged, Case-Control Studies, Circadian Rhythm, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Motor Activity, Predictive Value of Tests.

Abstract

Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow‐up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow‐up of patients. Sixty‐four consecutive HD patients and 67 age‐ and sex‐matched healthy controls were studied. Daytime motor activity was recorded using a wrist‐worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow‐up was available from 40 patients (mean follow‐up 2.0 years) and 29 controls (mean follow‐up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow‐up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow‐up. © 2001 Movement Disorder Society.

Url:

https://api.istex.fr/document/4B43B65CA0E4E157DA9E42D3E6F580153F58163A/fulltext/pdf

DOI: 10.1002/mds.1097

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000C62
to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000C62
to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002F35
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :006B90
to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002A03
to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :000318
to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002920
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :006E19
to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003D45
to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :003D45
to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003C61
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000506
to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000506
to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000506
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :006963

Links to Exploration step

ISTEX:4B43B65CA0E4E157DA9E42D3E6F580153F58163A

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease</title>
<author><name sortKey="Van Vugt, J P P" sort="Van Vugt, J P P" uniqKey="Van Vugt J" first="J. P. P." last="Van Vugt">J. P. P. Van Vugt</name>
</author>
<author><name sortKey="Siesling, S" sort="Siesling, S" uniqKey="Siesling S" first="S." last="Siesling">S. Siesling</name>
</author>
<author><name sortKey="Piet, K K E" sort="Piet, K K E" uniqKey="Piet K" first="K. K. E." last="Piet">K. K. E. Piet</name>
</author>
<author><name sortKey="Zwinderman, A H" sort="Zwinderman, A H" uniqKey="Zwinderman A" first="A. H." last="Zwinderman">A. H. Zwinderman</name>
</author>
<author><name sortKey="Middelkoop, H A M" sort="Middelkoop, H A M" uniqKey="Middelkoop H" first="H. A. M." last="Middelkoop">H. A. M. Middelkoop</name>
</author>
<author><name sortKey="Van Hilten, J J" sort="Van Hilten, J J" uniqKey="Van Hilten J" first="J. J." last="Van Hilten">J. J. Van Hilten</name>
</author>
<author><name sortKey="Roos, R A C" sort="Roos, R A C" uniqKey="Roos R" first="R. A. C." last="Roos">R. A. C. Roos</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:4B43B65CA0E4E157DA9E42D3E6F580153F58163A</idno>
<date when="2001" year="2001">2001</date>
<idno type="doi">10.1002/mds.1097</idno>
<idno type="url">https://api.istex.fr/document/4B43B65CA0E4E157DA9E42D3E6F580153F58163A/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C62</idno>
<idno type="wicri:Area/Istex/Curation">000C62</idno>
<idno type="wicri:Area/Istex/Checkpoint">002F35</idno>
<idno type="wicri:doubleKey">0885-3185:2001:Van Vugt J:quantitative:assessment:of</idno>
<idno type="wicri:Area/Main/Merge">006B90</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:01-0377462</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002A03</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000318</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002920</idno>
<idno type="wicri:doubleKey">0885-3185:2001:Van Vugt J:quantitative:assessment:of</idno>
<idno type="wicri:Area/Main/Merge">006E19</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:11391742</idno>
<idno type="wicri:Area/PubMed/Corpus">003D45</idno>
<idno type="wicri:Area/PubMed/Curation">003D45</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003C61</idno>
<idno type="wicri:Area/Ncbi/Merge">000506</idno>
<idno type="wicri:Area/Ncbi/Curation">000506</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000506</idno>
<idno type="wicri:doubleKey">0885-3185:2001:Van Vugt J:quantitative:assessment:of</idno>
<idno type="wicri:Area/Main/Merge">006963</idno>
<idno type="wicri:Area/Main/Curation">004708</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease</title>
<author><name sortKey="Van Vugt, J P P" sort="Van Vugt, J P P" uniqKey="Van Vugt J" first="J. P. P." last="Van Vugt">J. P. P. Van Vugt</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Siesling, S" sort="Siesling, S" uniqKey="Siesling S" first="S." last="Siesling">S. Siesling</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Piet, K K E" sort="Piet, K K E" uniqKey="Piet K" first="K. K. E." last="Piet">K. K. E. Piet</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zwinderman, A H" sort="Zwinderman, A H" uniqKey="Zwinderman A" first="A. H." last="Zwinderman">A. H. Zwinderman</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Statistics, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Middelkoop, H A M" sort="Middelkoop, H A M" uniqKey="Middelkoop H" first="H. A. M." last="Middelkoop">H. A. M. Middelkoop</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Hilten, J J" sort="Van Hilten, J J" uniqKey="Van Hilten J" first="J. J." last="Van Hilten">J. J. Van Hilten</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roos, R A C" sort="Roos, R A C" uniqKey="Roos R" first="R. A. C." last="Roos">R. A. C. Roos</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>John Wiley & Sons, Inc.</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2001-05">2001-05</date>
<biblScope unit="vol">16</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="481">481</biblScope>
<biblScope unit="page" to="488">488</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">4B43B65CA0E4E157DA9E42D3E6F580153F58163A</idno>
<idno type="DOI">10.1002/mds.1097</idno>
<idno type="ArticleID">MDS1097</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Case-Control Studies</term>
<term>Circadian Rhythm</term>
<term>Day</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Human</term>
<term>Humans</term>
<term>Huntington Disease (complications)</term>
<term>Huntington Disease (physiopathology)</term>
<term>Huntington disease</term>
<term>Huntington's disease</term>
<term>Hypokinesia (etiology)</term>
<term>Hypokinesia (physiopathology)</term>
<term>Male</term>
<term>Manual activity</term>
<term>Middle Aged</term>
<term>Monitoring, Ambulatory (methods)</term>
<term>Motor Activity</term>
<term>Motor handicap</term>
<term>Predictive Value of Tests</term>
<term>Prognosis</term>
<term>activity monitoring</term>
<term>follow‐up</term>
<term>functional capacity</term>
<term>voluntary movement</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hypokinesia</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Monitoring, Ambulatory</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Huntington Disease</term>
<term>Hypokinesia</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Case-Control Studies</term>
<term>Circadian Rhythm</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity</term>
<term>Predictive Value of Tests</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Activité manuelle</term>
<term>Chorée Huntington</term>
<term>Handicap moteur</term>
<term>Homme</term>
<term>Jour</term>
<term>Pronostic</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow‐up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow‐up of patients. Sixty‐four consecutive HD patients and 67 age‐ and sex‐matched healthy controls were studied. Daytime motor activity was recorded using a wrist‐worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow‐up was available from 40 patients (mean follow‐up 2.0 years) and 29 controls (mean follow‐up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow‐up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow‐up. © 2001 Movement Disorder Society.</div>
</front>
</TEI>
<double idat="0885-3185:2001:Van Vugt J:quantitative:assessment:of"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease</title>
<author><name sortKey="Van Vugt, J P P" sort="Van Vugt, J P P" uniqKey="Van Vugt J" first="J. P. P." last="Van Vugt">J. P. P. Van Vugt</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Siesling, S" sort="Siesling, S" uniqKey="Siesling S" first="S." last="Siesling">S. Siesling</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Piet, K K E" sort="Piet, K K E" uniqKey="Piet K" first="K. K. E." last="Piet">K. K. E. Piet</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zwinderman, A H" sort="Zwinderman, A H" uniqKey="Zwinderman A" first="A. H." last="Zwinderman">A. H. Zwinderman</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medical Statistics, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Middelkoop, H A M" sort="Middelkoop, H A M" uniqKey="Middelkoop H" first="H. A. M." last="Middelkoop">H. A. M. Middelkoop</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Hilten, J J" sort="Van Hilten, J J" uniqKey="Van Hilten J" first="J. J." last="Van Hilten">J. J. Van Hilten</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roos, R A C" sort="Roos, R A C" uniqKey="Roos R" first="R. A. C." last="Roos">R. A. C. Roos</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">01-0377462</idno>
<date when="2001">2001</date>
<idno type="stanalyst">PASCAL 01-0377462 INIST</idno>
<idno type="RBID">Pascal:01-0377462</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002A03</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000318</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002920</idno>
<idno type="wicri:doubleKey">0885-3185:2001:Van Vugt J:quantitative:assessment:of</idno>
<idno type="wicri:Area/Main/Merge">006E19</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease</title>
<author><name sortKey="Van Vugt, J P P" sort="Van Vugt, J P P" uniqKey="Van Vugt J" first="J. P. P." last="Van Vugt">J. P. P. Van Vugt</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Siesling, S" sort="Siesling, S" uniqKey="Siesling S" first="S." last="Siesling">S. Siesling</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Piet, K K E" sort="Piet, K K E" uniqKey="Piet K" first="K. K. E." last="Piet">K. K. E. Piet</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zwinderman, A H" sort="Zwinderman, A H" uniqKey="Zwinderman A" first="A. H." last="Zwinderman">A. H. Zwinderman</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medical Statistics, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Middelkoop, H A M" sort="Middelkoop, H A M" uniqKey="Middelkoop H" first="H. A. M." last="Middelkoop">H. A. M. Middelkoop</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Hilten, J J" sort="Van Hilten, J J" uniqKey="Van Hilten J" first="J. J." last="Van Hilten">J. J. Van Hilten</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roos, R A C" sort="Roos, R A C" uniqKey="Roos R" first="R. A. C." last="Roos">R. A. C. Roos</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2001">2001</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Day</term>
<term>Human</term>
<term>Huntington disease</term>
<term>Manual activity</term>
<term>Motor handicap</term>
<term>Prognosis</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Chorée Huntington</term>
<term>Activité manuelle</term>
<term>Jour</term>
<term>Handicap moteur</term>
<term>Pronostic</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow-up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow-up of patients. Sixty-four consecutive HD patients and 67 age- and sex-matched healthy controls were studied. Daytime motor activity was recorded using a wrist-worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow-up was available from 40 patients (mean follow-up 2.0 years) and 29 controls (mean follow-up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow-up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow-up.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease</title>
<author><name sortKey="Van Vugt, J P P" sort="Van Vugt, J P P" uniqKey="Van Vugt J" first="J. P. P." last="Van Vugt">J. P. P. Van Vugt</name>
</author>
<author><name sortKey="Siesling, S" sort="Siesling, S" uniqKey="Siesling S" first="S." last="Siesling">S. Siesling</name>
</author>
<author><name sortKey="Piet, K K E" sort="Piet, K K E" uniqKey="Piet K" first="K. K. E." last="Piet">K. K. E. Piet</name>
</author>
<author><name sortKey="Zwinderman, A H" sort="Zwinderman, A H" uniqKey="Zwinderman A" first="A. H." last="Zwinderman">A. H. Zwinderman</name>
</author>
<author><name sortKey="Middelkoop, H A M" sort="Middelkoop, H A M" uniqKey="Middelkoop H" first="H. A. M." last="Middelkoop">H. A. M. Middelkoop</name>
</author>
<author><name sortKey="Van Hilten, J J" sort="Van Hilten, J J" uniqKey="Van Hilten J" first="J. J." last="Van Hilten">J. J. Van Hilten</name>
</author>
<author><name sortKey="Roos, R A C" sort="Roos, R A C" uniqKey="Roos R" first="R. A. C." last="Roos">R. A. C. Roos</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:4B43B65CA0E4E157DA9E42D3E6F580153F58163A</idno>
<date when="2001" year="2001">2001</date>
<idno type="doi">10.1002/mds.1097</idno>
<idno type="url">https://api.istex.fr/document/4B43B65CA0E4E157DA9E42D3E6F580153F58163A/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000C62</idno>
<idno type="wicri:Area/Istex/Curation">000C62</idno>
<idno type="wicri:Area/Istex/Checkpoint">002F35</idno>
<idno type="wicri:doubleKey">0885-3185:2001:Van Vugt J:quantitative:assessment:of</idno>
<idno type="wicri:Area/Main/Merge">006B90</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease</title>
<author><name sortKey="Van Vugt, J P P" sort="Van Vugt, J P P" uniqKey="Van Vugt J" first="J. P. P." last="Van Vugt">J. P. P. Van Vugt</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Siesling, S" sort="Siesling, S" uniqKey="Siesling S" first="S." last="Siesling">S. Siesling</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Piet, K K E" sort="Piet, K K E" uniqKey="Piet K" first="K. K. E." last="Piet">K. K. E. Piet</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zwinderman, A H" sort="Zwinderman, A H" uniqKey="Zwinderman A" first="A. H." last="Zwinderman">A. H. Zwinderman</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Statistics, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Middelkoop, H A M" sort="Middelkoop, H A M" uniqKey="Middelkoop H" first="H. A. M." last="Middelkoop">H. A. M. Middelkoop</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Hilten, J J" sort="Van Hilten, J J" uniqKey="Van Hilten J" first="J. J." last="Van Hilten">J. J. Van Hilten</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roos, R A C" sort="Roos, R A C" uniqKey="Roos R" first="R. A. C." last="Roos">R. A. C. Roos</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>John Wiley & Sons, Inc.</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2001-05">2001-05</date>
<biblScope unit="vol">16</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="481">481</biblScope>
<biblScope unit="page" to="488">488</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">4B43B65CA0E4E157DA9E42D3E6F580153F58163A</idno>
<idno type="DOI">10.1002/mds.1097</idno>
<idno type="ArticleID">MDS1097</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Huntington's disease</term>
<term>activity monitoring</term>
<term>follow‐up</term>
<term>functional capacity</term>
<term>voluntary movement</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow‐up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow‐up of patients. Sixty‐four consecutive HD patients and 67 age‐ and sex‐matched healthy controls were studied. Daytime motor activity was recorded using a wrist‐worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow‐up was available from 40 patients (mean follow‐up 2.0 years) and 29 controls (mean follow‐up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow‐up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow‐up. © 2001 Movement Disorder Society.</div>
</front>
</TEI>
</ISTEX>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease.</title>
<author><name sortKey="Van Vugt, J P" sort="Van Vugt, J P" uniqKey="Van Vugt J" first="J P" last="Van Vugt">J P Van Vugt</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. j.p.p.van_vugt@lumc.nl</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden</wicri:regionArea>
<wicri:noRegion>2300 RC Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Siesling, S" sort="Siesling, S" uniqKey="Siesling S" first="S" last="Siesling">S. Siesling</name>
</author>
<author><name sortKey="Piet, K K" sort="Piet, K K" uniqKey="Piet K" first="K K" last="Piet">K K Piet</name>
</author>
<author><name sortKey="Zwinderman, A H" sort="Zwinderman, A H" uniqKey="Zwinderman A" first="A H" last="Zwinderman">A H Zwinderman</name>
</author>
<author><name sortKey="Middelkoop, H A" sort="Middelkoop, H A" uniqKey="Middelkoop H" first="H A" last="Middelkoop">H A Middelkoop</name>
</author>
<author><name sortKey="Van Hilten, J J" sort="Van Hilten, J J" uniqKey="Van Hilten J" first="J J" last="Van Hilten">J J Van Hilten</name>
</author>
<author><name sortKey="Roos, R A" sort="Roos, R A" uniqKey="Roos R" first="R A" last="Roos">R A Roos</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2001">2001</date>
<idno type="RBID">pubmed:11391742</idno>
<idno type="pmid">11391742</idno>
<idno type="wicri:Area/PubMed/Corpus">003D45</idno>
<idno type="wicri:Area/PubMed/Curation">003D45</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003C61</idno>
<idno type="wicri:Area/Ncbi/Merge">000506</idno>
<idno type="wicri:Area/Ncbi/Curation">000506</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000506</idno>
<idno type="wicri:doubleKey">0885-3185:2001:Van Vugt J:quantitative:assessment:of</idno>
<idno type="wicri:Area/Main/Merge">006963</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease.</title>
<author><name sortKey="Van Vugt, J P" sort="Van Vugt, J P" uniqKey="Van Vugt J" first="J P" last="Van Vugt">J P Van Vugt</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. j.p.p.van_vugt@lumc.nl</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden</wicri:regionArea>
<wicri:noRegion>2300 RC Leiden</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Siesling, S" sort="Siesling, S" uniqKey="Siesling S" first="S" last="Siesling">S. Siesling</name>
</author>
<author><name sortKey="Piet, K K" sort="Piet, K K" uniqKey="Piet K" first="K K" last="Piet">K K Piet</name>
</author>
<author><name sortKey="Zwinderman, A H" sort="Zwinderman, A H" uniqKey="Zwinderman A" first="A H" last="Zwinderman">A H Zwinderman</name>
</author>
<author><name sortKey="Middelkoop, H A" sort="Middelkoop, H A" uniqKey="Middelkoop H" first="H A" last="Middelkoop">H A Middelkoop</name>
</author>
<author><name sortKey="Van Hilten, J J" sort="Van Hilten, J J" uniqKey="Van Hilten J" first="J J" last="Van Hilten">J J Van Hilten</name>
</author>
<author><name sortKey="Roos, R A" sort="Roos, R A" uniqKey="Roos R" first="R A" last="Roos">R A Roos</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2001" type="published">2001</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Case-Control Studies</term>
<term>Circadian Rhythm</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Huntington Disease (complications)</term>
<term>Huntington Disease (physiopathology)</term>
<term>Hypokinesia (etiology)</term>
<term>Hypokinesia (physiopathology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Monitoring, Ambulatory (methods)</term>
<term>Motor Activity</term>
<term>Predictive Value of Tests</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hypokinesia</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Monitoring, Ambulatory</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Huntington Disease</term>
<term>Hypokinesia</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Case-Control Studies</term>
<term>Circadian Rhythm</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity</term>
<term>Predictive Value of Tests</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow-up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow-up of patients. Sixty-four consecutive HD patients and 67 age- and sex-matched healthy controls were studied. Daytime motor activity was recorded using a wrist-worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow-up was available from 40 patients (mean follow-up 2.0 years) and 29 controls (mean follow-up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow-up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow-up.</div>
</front>
</TEI>
</PubMed>
</double>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004708 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 004708 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Curation
   |type=    RBID
   |clé=     ISTEX:4B43B65CA0E4E157DA9E42D3E6F580153F58163A
   |texte=   Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Movement Disorders (revue)

Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease

Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri