Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease
Identifieur interne : 006E19 ( Main/Merge ); précédent : 006E18; suivant : 006E20Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease
Auteurs : J. P. P. Van Vugt [Pays-Bas] ; S. Siesling [Pays-Bas] ; K. K. E. Piet [Pays-Bas] ; A. H. Zwinderman [Pays-Bas] ; H. A. M. Middelkoop [Pays-Bas] ; J. J. Van Hilten [Pays-Bas] ; R. A. C. Roos [Pays-Bas]Source :
- Movement disorders [ 0885-3185 ] ; 2001.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow-up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow-up of patients. Sixty-four consecutive HD patients and 67 age- and sex-matched healthy controls were studied. Daytime motor activity was recorded using a wrist-worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow-up was available from 40 patients (mean follow-up 2.0 years) and 29 controls (mean follow-up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow-up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow-up.
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P. P." last="Van Vugt">J. P. P. Van Vugt</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Siesling, S" sort="Siesling, S" uniqKey="Siesling S" first="S." last="Siesling">S. 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Van Hilten</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Roos, R A C" sort="Roos, R A C" uniqKey="Roos R" first="R. A. C." last="Roos">R. A. C. Roos</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Day</term><term>Human</term><term>Huntington disease</term><term>Manual activity</term><term>Motor handicap</term><term>Prognosis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chorée Huntington</term><term>Activité manuelle</term><term>Jour</term><term>Handicap moteur</term><term>Pronostic</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow-up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow-up of patients. Sixty-four consecutive HD patients and 67 age- and sex-matched healthy controls were studied. Daytime motor activity was recorded using a wrist-worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow-up was available from 40 patients (mean follow-up 2.0 years) and 29 controls (mean follow-up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow-up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow-up.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li></region><settlement><li>Leyde</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Vugt, J P P" sort="Van Vugt, J P P" uniqKey="Van Vugt J" first="J. P. P." last="Van Vugt">J. P. P. Van Vugt</name></region><name sortKey="Middelkoop, H A M" sort="Middelkoop, H A M" uniqKey="Middelkoop H" first="H. A. M." last="Middelkoop">H. A. M. Middelkoop</name><name sortKey="Piet, K K E" sort="Piet, K K E" uniqKey="Piet K" first="K. K. E." last="Piet">K. K. E. Piet</name><name sortKey="Roos, R A C" sort="Roos, R A C" uniqKey="Roos R" first="R. A. C." last="Roos">R. A. C. Roos</name><name sortKey="Siesling, S" sort="Siesling, S" uniqKey="Siesling S" first="S." last="Siesling">S. Siesling</name><name sortKey="Van Hilten, J J" sort="Van Hilten, J J" uniqKey="Van Hilten J" first="J. J." last="Van Hilten">J. J. Van Hilten</name><name sortKey="Zwinderman, A H" sort="Zwinderman, A H" uniqKey="Zwinderman A" first="A. H." last="Zwinderman">A. H. Zwinderman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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