Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease.
Identifieur interne : 000506 ( Ncbi/Curation ); précédent : 000505; suivant : 000507Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease.
Auteurs : J P Van Vugt [Pays-Bas] ; S. Siesling ; K K Piet ; A H Zwinderman ; H A Middelkoop ; J J Van Hilten ; R A RoosSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2001.
English descriptors
- KwdEn :
- Adult, Aged, Case-Control Studies, Circadian Rhythm, Disease Progression, Female, Follow-Up Studies, Humans, Huntington Disease (complications), Huntington Disease (physiopathology), Hypokinesia (etiology), Hypokinesia (physiopathology), Male, Middle Aged, Monitoring, Ambulatory (methods), Motor Activity, Predictive Value of Tests.
- MESH :
- complications : Huntington Disease.
- etiology : Hypokinesia.
- methods : Monitoring, Ambulatory.
- physiopathology : Huntington Disease, Hypokinesia.
- Adult, Aged, Case-Control Studies, Circadian Rhythm, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Motor Activity, Predictive Value of Tests.
Abstract
Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow-up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow-up of patients. Sixty-four consecutive HD patients and 67 age- and sex-matched healthy controls were studied. Daytime motor activity was recorded using a wrist-worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow-up was available from 40 patients (mean follow-up 2.0 years) and 29 controls (mean follow-up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow-up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow-up.
PubMed: 11391742
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<front><div type="abstract" xml:lang="en">Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow-up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow-up of patients. Sixty-four consecutive HD patients and 67 age- and sex-matched healthy controls were studied. Daytime motor activity was recorded using a wrist-worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow-up was available from 40 patients (mean follow-up 2.0 years) and 29 controls (mean follow-up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow-up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow-up.</div>
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