Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease.
Identifieur interne : 000506 ( Ncbi/Curation ); précédent : 000505; suivant : 000507Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease.
Auteurs : J P Van Vugt [Pays-Bas] ; S. Siesling ; K K Piet ; A H Zwinderman ; H A Middelkoop ; J J Van Hilten ; R A RoosSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2001.
English descriptors
- KwdEn :
- Adult, Aged, Case-Control Studies, Circadian Rhythm, Disease Progression, Female, Follow-Up Studies, Humans, Huntington Disease (complications), Huntington Disease (physiopathology), Hypokinesia (etiology), Hypokinesia (physiopathology), Male, Middle Aged, Monitoring, Ambulatory (methods), Motor Activity, Predictive Value of Tests.
- MESH :
- complications : Huntington Disease.
- etiology : Hypokinesia.
- methods : Monitoring, Ambulatory.
- physiopathology : Huntington Disease, Hypokinesia.
- Adult, Aged, Case-Control Studies, Circadian Rhythm, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Motor Activity, Predictive Value of Tests.
Abstract
Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow-up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow-up of patients. Sixty-four consecutive HD patients and 67 age- and sex-matched healthy controls were studied. Daytime motor activity was recorded using a wrist-worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow-up was available from 40 patients (mean follow-up 2.0 years) and 29 controls (mean follow-up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow-up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow-up.
PubMed: 11391742
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Siesling</name></author><author><name sortKey="Piet, K K" sort="Piet, K K" uniqKey="Piet K" first="K K" last="Piet">K K Piet</name></author><author><name sortKey="Zwinderman, A H" sort="Zwinderman, A H" uniqKey="Zwinderman A" first="A H" last="Zwinderman">A H Zwinderman</name></author><author><name sortKey="Middelkoop, H A" sort="Middelkoop, H A" uniqKey="Middelkoop H" first="H A" last="Middelkoop">H A Middelkoop</name></author><author><name sortKey="Van Hilten, J J" sort="Van Hilten, J J" uniqKey="Van Hilten J" first="J J" last="Van Hilten">J J Van Hilten</name></author><author><name sortKey="Roos, R A" sort="Roos, R A" uniqKey="Roos R" first="R A" last="Roos">R A Roos</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11391742</idno><idno type="pmid">11391742</idno><idno type="wicri:Area/PubMed/Corpus">003D45</idno><idno type="wicri:Area/PubMed/Curation">003D45</idno><idno type="wicri:Area/PubMed/Checkpoint">003C61</idno><idno type="wicri:Area/Ncbi/Merge">000506</idno><idno type="wicri:Area/Ncbi/Curation">000506</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease.</title><author><name sortKey="Van Vugt, J P" sort="Van Vugt, J P" uniqKey="Van Vugt J" first="J P" last="Van Vugt">J P Van Vugt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. j.p.p.van_vugt@lumc.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden</wicri:regionArea><wicri:noRegion>2300 RC Leiden</wicri:noRegion></affiliation></author><author><name sortKey="Siesling, S" sort="Siesling, S" uniqKey="Siesling S" first="S" last="Siesling">S. Siesling</name></author><author><name sortKey="Piet, K K" sort="Piet, K K" uniqKey="Piet K" first="K K" last="Piet">K K Piet</name></author><author><name sortKey="Zwinderman, A H" sort="Zwinderman, A H" uniqKey="Zwinderman A" first="A H" last="Zwinderman">A H Zwinderman</name></author><author><name sortKey="Middelkoop, H A" sort="Middelkoop, H A" uniqKey="Middelkoop H" first="H A" last="Middelkoop">H A Middelkoop</name></author><author><name sortKey="Van Hilten, J J" sort="Van Hilten, J J" uniqKey="Van Hilten J" first="J J" last="Van Hilten">J J Van Hilten</name></author><author><name sortKey="Roos, R A" sort="Roos, R A" uniqKey="Roos R" first="R A" last="Roos">R A Roos</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Circadian Rhythm</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington Disease (physiopathology)</term><term>Hypokinesia (etiology)</term><term>Hypokinesia (physiopathology)</term><term>Male</term><term>Middle Aged</term><term>Monitoring, Ambulatory (methods)</term><term>Motor Activity</term><term>Predictive Value of Tests</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hypokinesia</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Monitoring, Ambulatory</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Huntington Disease</term><term>Hypokinesia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Circadian Rhythm</term><term>Disease Progression</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Activity</term><term>Predictive Value of Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow-up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow-up of patients. Sixty-four consecutive HD patients and 67 age- and sex-matched healthy controls were studied. Daytime motor activity was recorded using a wrist-worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow-up was available from 40 patients (mean follow-up 2.0 years) and 29 controls (mean follow-up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow-up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow-up.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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