Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease
Identifieur interne : 000C62 ( Istex/Corpus ); précédent : 000C61; suivant : 000C63Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease
Auteurs : J. P. P. Van Vugt ; S. Siesling ; K. K. E. Piet ; A. H. Zwinderman ; H. A. M. Middelkoop ; J. J. Van Hilten ; R. A. C. RoosSource :
- Movement Disorders [ 0885-3185 ] ; 2001-05.
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- KwdEn :
Abstract
Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow‐up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow‐up of patients. Sixty‐four consecutive HD patients and 67 age‐ and sex‐matched healthy controls were studied. Daytime motor activity was recorded using a wrist‐worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow‐up was available from 40 patients (mean follow‐up 2.0 years) and 29 controls (mean follow‐up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow‐up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow‐up. © 2001 Movement Disorder Society.
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DOI: 10.1002/mds.1097
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Zwinderman</name><affiliation><mods:affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Middelkoop, H A M" sort="Middelkoop, H A M" uniqKey="Middelkoop H" first="H. A. M." last="Middelkoop">H. A. M. Middelkoop</name><affiliation><mods:affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van Hilten, J J" sort="Van Hilten, J J" uniqKey="Van Hilten J" first="J. J." last="Van Hilten">J. J. Van Hilten</name><affiliation><mods:affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Roos, R A C" sort="Roos, R A C" uniqKey="Roos R" first="R. A. C." last="Roos">R. A. C. Roos</name><affiliation><mods:affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-05">2001-05</date><biblScope unit="vol">16</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="481">481</biblScope><biblScope unit="page" to="488">488</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">4B43B65CA0E4E157DA9E42D3E6F580153F58163A</idno><idno type="DOI">10.1002/mds.1097</idno><idno type="ArticleID">MDS1097</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Huntington's disease</term><term>activity monitoring</term><term>follow‐up</term><term>functional capacity</term><term>voluntary movement</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow‐up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow‐up of patients. Sixty‐four consecutive HD patients and 67 age‐ and sex‐matched healthy controls were studied. Daytime motor activity was recorded using a wrist‐worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow‐up was available from 40 patients (mean follow‐up 2.0 years) and 29 controls (mean follow‐up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow‐up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow‐up. © 2001 Movement Disorder Society.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>J.P.P. van Vugt MD</name><affiliations><json:string>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</json:string></affiliations></json:item><json:item><name>S. Siesling PhD</name><affiliations><json:string>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</json:string></affiliations></json:item><json:item><name>K.K.E. Piet MSc</name><affiliations><json:string>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</json:string></affiliations></json:item><json:item><name>A.H. Zwinderman PhD</name><affiliations><json:string>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands</json:string></affiliations></json:item><json:item><name>H.A.M. Middelkoop PhD</name><affiliations><json:string>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</json:string></affiliations></json:item><json:item><name>J.J. van Hilten MD, PhD</name><affiliations><json:string>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</json:string></affiliations></json:item><json:item><name>R.A.C. 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We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow‐up of patients.Sixty‐four consecutive HD patients and 67 age‐ and sex‐matched healthy controls were studied. Daytime motor activity was recorded using a wrist‐worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow‐up was available from 40 patients (mean follow‐up 2.0 years) and 29 controls (mean follow‐up 5.9 years).Despite chorea, patients had less daytime motor activity than controls (P > 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P > 0.01), disturbed posture & gait (r = 0.38; P > 0.005) and especially with reduced functional capacity (r = 0.51; P > 0.0005). During follow‐up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P > 0.005).Hypokinesia seems a core symptom of HD which is related to functional capacity. 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Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2001-05"></date><biblScope unit="vol">16</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="481">481</biblScope><biblScope unit="page" to="488">488</biblScope></imprint></monogr><idno type="istex">4B43B65CA0E4E157DA9E42D3E6F580153F58163A</idno><idno type="DOI">10.1002/mds.1097</idno><idno type="ArticleID">MDS1097</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2001</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow‐up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow‐up of patients.Sixty‐four consecutive HD patients and 67 age‐ and sex‐matched healthy controls were studied. Daytime motor activity was recorded using a wrist‐worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow‐up was available from 40 patients (mean follow‐up 2.0 years) and 29 controls (mean follow‐up 5.9 years).Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow‐up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005).Hypokinesia seems a core symptom of HD which is related to functional capacity. 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Therefore, quantitative assessment of disturbed voluntary movement might be important in follow‐up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow‐up of patients.</p><p>Sixty‐four consecutive HD patients and 67 age‐ and sex‐matched healthy controls were studied. Daytime motor activity was recorded using a wrist‐worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow‐up was available from 40 patients (mean follow‐up 2.0 years) and 29 controls (mean follow‐up 5.9 years).</p><p>Despite chorea, patients had less daytime motor activity than controls (<i>P</i> < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; <i>P</i> < 0.01), disturbed posture & gait (r = 0.38; <i>P</i> < 0.005) and especially with reduced functional capacity (r = 0.51; <i>P</i> < 0.0005). During follow‐up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (<i>P</i> < 0.005).</p><p>Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow‐up. © 2001 Movement Disorder Society.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Reduced Motor Activity in Huntington's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease</title></titleInfo><name type="personal"><namePart type="given">J.P.P.</namePart><namePart type="family">van Vugt</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</affiliation><description>Correspondence: Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Siesling</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.K.E.</namePart><namePart type="family">Piet</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.H.</namePart><namePart type="family">Zwinderman</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.A.M.</namePart><namePart type="family">Middelkoop</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.J.</namePart><namePart type="family">van Hilten</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.A.C.</namePart><namePart type="family">Roos</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2001-05</dateIssued><dateCaptured encoding="w3cdtf">2000-04-10</dateCaptured><dateValid encoding="w3cdtf">2000-09-19</dateValid><copyrightDate encoding="w3cdtf">2001</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">4</extent><extent unit="references">27</extent><extent unit="words">3956</extent></physicalDescription><abstract lang="en">Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow‐up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow‐up of patients. Sixty‐four consecutive HD patients and 67 age‐ and sex‐matched healthy controls were studied. Daytime motor activity was recorded using a wrist‐worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow‐up was available from 40 patients (mean follow‐up 2.0 years) and 29 controls (mean follow‐up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow‐up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow‐up. © 2001 Movement Disorder Society.</abstract><subject lang="en"><genre>Keywords</genre><topic>Huntington's disease</topic><topic>voluntary movement</topic><topic>functional capacity</topic><topic>activity monitoring</topic><topic>follow‐up</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>481</start><end>488</end><total>8</total></extent></part></relatedItem><identifier type="istex">4B43B65CA0E4E157DA9E42D3E6F580153F58163A</identifier><identifier type="DOI">10.1002/mds.1097</identifier><identifier type="ArticleID">MDS1097</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2001 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>John Wiley & Sons, Inc.</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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