Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease
Identifieur interne : 000C62 ( Istex/Corpus ); précédent : 000C61; suivant : 000C63Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease
Auteurs : J. P. P. Van Vugt ; S. Siesling ; K. K. E. Piet ; A. H. Zwinderman ; H. A. M. Middelkoop ; J. J. Van Hilten ; R. A. C. RoosSource :
- Movement Disorders [ 0885-3185 ] ; 2001-05.
English descriptors
- KwdEn :
Abstract
Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow‐up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow‐up of patients. Sixty‐four consecutive HD patients and 67 age‐ and sex‐matched healthy controls were studied. Daytime motor activity was recorded using a wrist‐worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow‐up was available from 40 patients (mean follow‐up 2.0 years) and 29 controls (mean follow‐up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow‐up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow‐up. © 2001 Movement Disorder Society.
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DOI: 10.1002/mds.1097
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<front><div type="abstract" xml:lang="en">Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow‐up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow‐up of patients. Sixty‐four consecutive HD patients and 67 age‐ and sex‐matched healthy controls were studied. Daytime motor activity was recorded using a wrist‐worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow‐up was available from 40 patients (mean follow‐up 2.0 years) and 29 controls (mean follow‐up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow‐up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow‐up. © 2001 Movement Disorder Society.</div>
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<contactDetails><email>j.p.p.van_vugt@lumc.nl</email>
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<creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>S.</givenNames>
<familyName>Siesling</familyName>
<degrees>PhD</degrees>
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<creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>K.K.E.</givenNames>
<familyName>Piet</familyName>
<degrees>MSc</degrees>
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<degrees>PhD</degrees>
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<creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>H.A.M.</givenNames>
<familyName>Middelkoop</familyName>
<degrees>PhD</degrees>
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<creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>J.J.</givenNames>
<familyName>van Hilten</familyName>
<degrees>MD, PhD</degrees>
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<familyName>Roos</familyName>
<degrees>MD, PhD</degrees>
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<affiliationGroup><affiliation xml:id="af1" countryCode="NL" type="organization"><unparsedAffiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</unparsedAffiliation>
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<affiliation xml:id="af2" countryCode="NL" type="organization"><unparsedAffiliation>Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands</unparsedAffiliation>
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<keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Huntington's disease</keyword>
<keyword xml:id="kwd2">voluntary movement</keyword>
<keyword xml:id="kwd3">functional capacity</keyword>
<keyword xml:id="kwd4">activity monitoring</keyword>
<keyword xml:id="kwd5">follow‐up</keyword>
</keywordGroup>
<abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title>
<p>Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow‐up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow‐up of patients.</p>
<p>Sixty‐four consecutive HD patients and 67 age‐ and sex‐matched healthy controls were studied. Daytime motor activity was recorded using a wrist‐worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow‐up was available from 40 patients (mean follow‐up 2.0 years) and 29 controls (mean follow‐up 5.9 years).</p>
<p>Despite chorea, patients had less daytime motor activity than controls (<i>P</i>
< 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; <i>P</i>
< 0.01), disturbed posture & gait (r = 0.38; <i>P</i>
< 0.005) and especially with reduced functional capacity (r = 0.51; <i>P</i>
< 0.0005). During follow‐up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (<i>P</i>
< 0.005).</p>
<p>Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow‐up. © 2001 Movement Disorder Society.</p>
</abstract>
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<!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease</title>
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<titleInfo type="abbreviated" lang="en"><title>Reduced Motor Activity in Huntington's Disease</title>
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<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease</title>
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<affiliation>Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands</affiliation>
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<abstract lang="en">Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow‐up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow‐up of patients. Sixty‐four consecutive HD patients and 67 age‐ and sex‐matched healthy controls were studied. Daytime motor activity was recorded using a wrist‐worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow‐up was available from 40 patients (mean follow‐up 2.0 years) and 29 controls (mean follow‐up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow‐up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow‐up. © 2001 Movement Disorder Society.</abstract>
<subject lang="en"><genre>Keywords</genre>
<topic>Huntington's disease</topic>
<topic>voluntary movement</topic>
<topic>functional capacity</topic>
<topic>activity monitoring</topic>
<topic>follow‐up</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Movement Disorders</title>
<subTitle>Official Journal of the Movement Disorder Society</subTitle>
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<titleInfo type="abbreviated"><title>Mov. Disord.</title>
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<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part><date>2001</date>
<detail type="volume"><caption>vol.</caption>
<number>16</number>
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<detail type="issue"><caption>no.</caption>
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<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2001 Movement Disorder Society</accessCondition>
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