Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease
Identifieur interne : 002A03 ( PascalFrancis/Corpus ); précédent : 002A02; suivant : 002A04Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease
Auteurs : J. P. P. Van Vugt ; S. Siesling ; K. K. E. Piet ; A. H. Zwinderman ; H. A. M. Middelkoop ; J. J. Van Hilten ; R. A. C. RoosSource :
- Movement disorders [ 0885-3185 ] ; 2001.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow-up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow-up of patients. Sixty-four consecutive HD patients and 67 age- and sex-matched healthy controls were studied. Daytime motor activity was recorded using a wrist-worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow-up was available from 40 patients (mean follow-up 2.0 years) and 29 controls (mean follow-up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow-up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow-up.
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Format Inist (serveur)
NO : | PASCAL 01-0377462 INIST |
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ET : | Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease |
AU : | VAN VUGT (J. P. P.); SIESLING (S.); PIET (K. K. E.); ZWINDERMAN (A. H.); MIDDELKOOP (H. A. M.); VAN HILTEN (J. J.); ROOS (R. A. C.) |
AF : | Department of Neurology, Leiden University Medical Center/Leiden/Pays-Bas (1 aut., 2 aut., 3 aut., 5 aut., 6 aut., 7 aut.); Department of Medical Statistics, Leiden University Medical Center/Leiden/Pays-Bas (4 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2001; Vol. 16; No. 3; Pp. 481-488; Bibl. 27 ref. |
LA : | Anglais |
EA : | Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow-up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow-up of patients. Sixty-four consecutive HD patients and 67 age- and sex-matched healthy controls were studied. Daytime motor activity was recorded using a wrist-worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow-up was available from 40 patients (mean follow-up 2.0 years) and 29 controls (mean follow-up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow-up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow-up. |
CC : | 002B17G |
FD : | Chorée Huntington; Activité manuelle; Jour; Handicap moteur; Pronostic; Homme |
FG : | Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire |
ED : | Huntington disease; Manual activity; Day; Motor handicap; Prognosis; Human |
EG : | Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease |
SD : | Corea Huntington; Actividad manual; Día; Deficiencia motora; Pronóstico; Hombre |
LO : | INIST-20953.354000099011180110 |
ID : | 01-0377462 |
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<front><div type="abstract" xml:lang="en">Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow-up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow-up of patients. Sixty-four consecutive HD patients and 67 age- and sex-matched healthy controls were studied. Daytime motor activity was recorded using a wrist-worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow-up was available from 40 patients (mean follow-up 2.0 years) and 29 controls (mean follow-up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow-up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow-up.</div>
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<ET>Quantitative assessment of daytime motor activity provides a responsive measure of functional decline in patients with Huntington's disease</ET>
<AU>VAN VUGT (J. P. P.); SIESLING (S.); PIET (K. K. E.); ZWINDERMAN (A. H.); MIDDELKOOP (H. A. M.); VAN HILTEN (J. J.); ROOS (R. A. C.)</AU>
<AF>Department of Neurology, Leiden University Medical Center/Leiden/Pays-Bas (1 aut., 2 aut., 3 aut., 5 aut., 6 aut., 7 aut.); Department of Medical Statistics, Leiden University Medical Center/Leiden/Pays-Bas (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2001; Vol. 16; No. 3; Pp. 481-488; Bibl. 27 ref.</SO>
<LA>Anglais</LA>
<EA>Voluntary motor impairment is a functionally important aspect of Huntington's disease (HD). Therefore, quantitative assessment of disturbed voluntary movement might be important in follow-up. We investigated the relation between quantitatively assessed daytime motor activity and symptom severity in HD and evaluated whether assessment of daytime motor activity is a responsive measure in the follow-up of patients. Sixty-four consecutive HD patients and 67 age- and sex-matched healthy controls were studied. Daytime motor activity was recorded using a wrist-worn activity monitor that counts all movements during a period of five consecutive days. Patients were rated clinically for voluntary motor impairment, dyskinesias, posture & gait, depression, cognitive impairment and functional capacity. Follow-up was available from 40 patients (mean follow-up 2.0 years) and 29 controls (mean follow-up 5.9 years). Despite chorea, patients had less daytime motor activity than controls (P < 0.005). This hypokinesia correlated with impaired voluntary movements (r = 0.37; P < 0.01), disturbed posture & gait (r = 0.38; P < 0.005) and especially with reduced functional capacity (r = 0.51; P < 0.0005). During follow-up, hypokinesia remained unchanged in clinically stable patients, but became worse in those whose functional disability progressed (P < 0.005). Hypokinesia seems a core symptom of HD which is related to functional capacity. Actimetric assessment of hypokinesia is responsive to disease progression and can be used as an objective tool for follow-up.</EA>
<CC>002B17G</CC>
<FD>Chorée Huntington; Activité manuelle; Jour; Handicap moteur; Pronostic; Homme</FD>
<FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Maladie héréditaire</FG>
<ED>Huntington disease; Manual activity; Day; Motor handicap; Prognosis; Human</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Genetic disease</EG>
<SD>Corea Huntington; Actividad manual; Día; Deficiencia motora; Pronóstico; Hombre</SD>
<LO>INIST-20953.354000099011180110</LO>
<ID>01-0377462</ID>
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