Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease
Identifieur interne : 004428 ( Main/Curation ); précédent : 004427; suivant : 004429Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease
Auteurs : Luc J. P. Defebvre [France] ; Pierre Krystkowiak [France] ; Jean-Louis Blatt [France] ; Alain Duhamel [France] ; Jean-Louis Bourriez [France] ; Myriame Périna [France] ; Serge Blond [France] ; Jean-Daniel Guieu [France] ; Alain Destée [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-01.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
- Adult, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Antiparkinson agent, Chemotherapy, Combined Modality Therapy, Disability Evaluation, Electric Stimulation Therapy (methods), Electrical stimulus, Equilibrium, Female, Gait (drug effects), Globus Pallidus (physiology), Humans, Instrumentation therapy, Kinematics, Levodopa, Levodopa (pharmacology), Levodopa (therapeutic use), L‐dopa, Male, Middle Aged, Movement Disorders (diagnosis), Pallidum, Parkinson Disease (drug therapy), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Posture, Prognosis, Walking, gait, pallidal stimulation, preparatory postural adjustments.
- MESH :
- chemical , pharmacology : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- diagnosis : Movement Disorders.
- drug effects : Gait.
- drug therapy : Parkinson Disease.
- methods : Electric Stimulation Therapy.
- physiology : Globus Pallidus.
- therapy : Parkinson Disease.
- Combined Modality Therapy, Disability Evaluation, Female, Humans, Male, Middle Aged, Posture.
Abstract
In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off‐ and on‐drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L‐dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L‐dopa. GPi stimulation and L‐dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity, the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase. This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L‐dopa. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1262
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<term>Antiparkinson Agents (pharmacology)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Antiparkinson agent</term>
<term>Chemotherapy</term>
<term>Combined Modality Therapy</term>
<term>Disability Evaluation</term>
<term>Electric Stimulation Therapy (methods)</term>
<term>Electrical stimulus</term>
<term>Equilibrium</term>
<term>Female</term>
<term>Gait (drug effects)</term>
<term>Globus Pallidus (physiology)</term>
<term>Humans</term>
<term>Instrumentation therapy</term>
<term>Kinematics</term>
<term>Levodopa</term>
<term>Levodopa (pharmacology)</term>
<term>Levodopa (therapeutic use)</term>
<term>L‐dopa</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Movement Disorders (diagnosis)</term>
<term>Pallidum</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Posture</term>
<term>Prognosis</term>
<term>Walking</term>
<term>gait</term>
<term>pallidal stimulation</term>
<term>preparatory postural adjustments</term>
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<term>Levodopa</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
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<term>Cinématique</term>
<term>Equilibre</term>
<term>Lévodopa</term>
<term>Marche à pied</term>
<term>Pallidum</term>
<term>Parkinson maladie</term>
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<term>Stimulus électrique</term>
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<front><div type="abstract" xml:lang="en">In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off‐ and on‐drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L‐dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L‐dopa. GPi stimulation and L‐dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity, the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase. This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L‐dopa. © 2001 Movement Disorder Society.</div>
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<author><name sortKey="Bourriez, Jean Louis" sort="Bourriez, Jean Louis" uniqKey="Bourriez J" first="Jean-Louis" last="Bourriez">Jean-Louis Bourriez</name>
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<author><name sortKey="Perina, Myriame" sort="Perina, Myriame" uniqKey="Perina M" first="Myriame" last="Perina">Myriame Perina</name>
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<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destee">Alain Destée</name>
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<placeName><settlement type="city">Lille</settlement>
</placeName>
<placeName><settlement type="city">Lille</settlement>
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</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology and Movement Disorders Unit, University of Lille</s1>
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<s3>FRA</s3>
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<placeName><settlement type="city">Lille</settlement>
</placeName>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
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</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">02-0207158</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease</title>
<author><name sortKey="Defebvre, Luc J P" sort="Defebvre, Luc J P" uniqKey="Defebvre L" first="Luc J. P." last="Defebvre">Luc J. P. Defebvre</name>
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<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology and Movement Disorders Unit, University of Lille</s1>
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<placeName><settlement type="city">Lille</settlement>
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</affiliation>
</author>
<author><name sortKey="Krystkowiak, Pierre" sort="Krystkowiak, Pierre" uniqKey="Krystkowiak P" first="Pierre" last="Krystkowiak">Pierre Krystkowiak</name>
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<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology and Movement Disorders Unit, University of Lille</s1>
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</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blatt, Jean Louis" sort="Blatt, Jean Louis" uniqKey="Blatt J" first="Jean-Louis" last="Blatt">Jean-Louis Blatt</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Gait Analysis, University of Lille</s1>
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<s3>FRA</s3>
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<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
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<s2>Lille</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
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<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Medical Informatics, University of Lille</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bourriez, Jean Louis" sort="Bourriez, Jean Louis" uniqKey="Bourriez J" first="Jean-Louis" last="Bourriez">Jean-Louis Bourriez</name>
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<placeName><settlement type="city">Lille</settlement>
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<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Clinical Neurophysiology, University of Lille</s1>
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<sZ>8 aut.</sZ>
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<author><name sortKey="Perina, Myriame" sort="Perina, Myriame" uniqKey="Perina M" first="Myriame" last="Perina">Myriame Perina</name>
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<placeName><settlement type="city">Lille</settlement>
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<author><name sortKey="Blond, Serge" sort="Blond, Serge" uniqKey="Blond S" first="Serge" last="Blond">Serge Blond</name>
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<placeName><settlement type="city">Lille</settlement>
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<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurosurgery, University of Lille</s1>
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<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guieu, Jean Daniel" sort="Guieu, Jean Daniel" uniqKey="Guieu J" first="Jean-Daniel" last="Guieu">Jean-Daniel Guieu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Gait Analysis, University of Lille</s1>
<s2>Lille</s2>
<s3>FRA</s3>
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<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Clinical Neurophysiology, University of Lille</s1>
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<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destee">Alain Destée</name>
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<s2>Lille</s2>
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<placeName><settlement type="city">Lille</settlement>
</placeName>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology and Movement Disorders Unit, University of Lille</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<placeName><settlement type="city">Lille</settlement>
</placeName>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2002">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Antiparkinson agent</term>
<term>Chemotherapy</term>
<term>Electrical stimulus</term>
<term>Equilibrium</term>
<term>Instrumentation therapy</term>
<term>Kinematics</term>
<term>Levodopa</term>
<term>Pallidum</term>
<term>Parkinson disease</term>
<term>Prognosis</term>
<term>Walking</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Stimulus électrique</term>
<term>Pallidum</term>
<term>Lévodopa</term>
<term>Chimiothérapie</term>
<term>Antiparkinsonien</term>
<term>Equilibre</term>
<term>Marche à pied</term>
<term>Cinématique</term>
<term>Traitement instrumental</term>
<term>Pronostic</term>
<term>Adulte</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term>
</keywords>
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</teiHeader>
<front><div type="abstract" xml:lang="en">In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off- and on-drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L-dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L-dopa. GPi stimulation and L-dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L-dopa.</div>
</front>
</TEI>
</INIST>
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<author><name sortKey="Defebvre, Luc J P" sort="Defebvre, Luc J P" uniqKey="Defebvre L" first="Luc J. P." last="Defebvre">Luc J. P. Defebvre</name>
</author>
<author><name sortKey="Krystkowiak, Pierre" sort="Krystkowiak, Pierre" uniqKey="Krystkowiak P" first="Pierre" last="Krystkowiak">Pierre Krystkowiak</name>
</author>
<author><name sortKey="Blatt, Jean Ouis" sort="Blatt, Jean Ouis" uniqKey="Blatt J" first="Jean-Louis" last="Blatt">Jean-Louis Blatt</name>
</author>
<author><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name>
</author>
<author><name sortKey="Bourriez, Jean Ouis" sort="Bourriez, Jean Ouis" uniqKey="Bourriez J" first="Jean-Louis" last="Bourriez">Jean-Louis Bourriez</name>
</author>
<author><name sortKey="Perina, Myriame" sort="Perina, Myriame" uniqKey="Perina M" first="Myriame" last="Périna">Myriame Périna</name>
</author>
<author><name sortKey="Blond, Serge" sort="Blond, Serge" uniqKey="Blond S" first="Serge" last="Blond">Serge Blond</name>
</author>
<author><name sortKey="Guieu, Jean Aniel" sort="Guieu, Jean Aniel" uniqKey="Guieu J" first="Jean-Daniel" last="Guieu">Jean-Daniel Guieu</name>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Lille</settlement>
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<date when="2002" year="2002">2002</date>
<idno type="doi">10.1002/mds.1262</idno>
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<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease</title>
<author><name sortKey="Defebvre, Luc J P" sort="Defebvre, Luc J P" uniqKey="Defebvre L" first="Luc J. P." last="Defebvre">Luc J. P. Defebvre</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology and Movement Disorders Unit, University of Lille, Lille</wicri:regionArea>
<placeName><settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krystkowiak, Pierre" sort="Krystkowiak, Pierre" uniqKey="Krystkowiak P" first="Pierre" last="Krystkowiak">Pierre Krystkowiak</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
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<affiliation wicri:level="1"><country xml:lang="fr">France</country>
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<author><name sortKey="Blatt, Jean Ouis" sort="Blatt, Jean Ouis" uniqKey="Blatt J" first="Jean-Louis" last="Blatt">Jean-Louis Blatt</name>
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<affiliation wicri:level="1"><country xml:lang="fr">France</country>
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<author><name sortKey="Bourriez, Jean Ouis" sort="Bourriez, Jean Ouis" uniqKey="Bourriez J" first="Jean-Louis" last="Bourriez">Jean-Louis Bourriez</name>
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<author><name sortKey="Blond, Serge" sort="Blond, Serge" uniqKey="Blond S" first="Serge" last="Blond">Serge Blond</name>
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<placeName><settlement type="city">Lille</settlement>
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<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
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<front><div type="abstract" xml:lang="en">In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off‐ and on‐drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L‐dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L‐dopa. GPi stimulation and L‐dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity, the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase. This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L‐dopa. © 2001 Movement Disorder Society.</div>
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<front><div type="abstract" xml:lang="en">In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off- and on-drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L-dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L-dopa. GPi stimulation and L-dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity, the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase. This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L-dopa.</div>
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