MovDisordV3, Main, Curation, bibRecord, 004427

Interaction of levodopa and cues on voluntary reaching in Parkinson's disease

Identifieur interne : 004427 ( Main/Curation ); précédent : 004426; suivant : 004428

Interaction of levodopa and cues on voluntary reaching in Parkinson's disease

Auteurs : Valerie E. Kelly [États-Unis] ; Allie S. Hyngstrom [États-Unis] ; Melissa M. Rundle [États-Unis] ; Amy J. Bastian [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2002-01.

RBID : ISTEX:597EDDD10BB7D74FDD91A0CF196FF2747FB0A6C2

Descripteurs français

Pascal (Inist)
- Antiparkinsonien, Atteignabilité, Bradykinésie, Chimiothérapie, Cinématique, Evaluation performance, Lévodopa, Mouvement corporel, Parkinson maladie, Personne âgée, Stimulus lumineux, Traitement.
Wicri :
- topic : Personne âgée.

English descriptors

KwdEn :
- Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Antiparkinson agent, Body movement, Chemotherapy, Cues, Elderly, Female, Humans, Hypokinesia (diagnosis), Hypokinesia (etiology), Kinematics, Levodopa, Levodopa (therapeutic use), Light stimulus, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Performance evaluation, Reachability, Severity of Illness Index, Treatment, bradykinesia, external cues, levodopa, movement.
MESH :
- chemical , pharmacology : Antiparkinson Agents.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- complications : Parkinson Disease.
- diagnosis : Hypokinesia.
- drug therapy : Parkinson Disease.
- etiology : Hypokinesia.
- Cues, Female, Humans, Male, Middle Aged, Severity of Illness Index.

Abstract

The bradykinesia associated with Parkinson's disease (PD) can be improved by both levodopa and the use of external cues. We examined the combined effect of levodopa and external cueing on the voluntary reaching movements of individuals with PD. Nine subjects with PD and nine matched controls were studied reaching to a ball target. Subjects with PD were studied after being off levodopa overnight and again on their morning dose. Kinematic data were collected as all subjects made both accurate and fast reaches under two different cue conditions: noncued (self‐initiated) and cued (triggered by a light). Subjects with PD reached more slowly than controls under all conditions. PD subjects increased their reach velocity and decreased movement time after taking levodopa and also when moving to a cue. However, the effects of levodopa and cueing were not additive. Instead, levodopa improved reach velocity to a greater extent in the noncued vs. cued condition. We also found that levodopa improved accurate (self‐paced) reaches more than fast reaches. These data suggest that levodopa may preferentially improve voluntary reaches that are more internally generated. © 2002 Movement Disorder Society.

Url:

https://api.istex.fr/document/597EDDD10BB7D74FDD91A0CF196FF2747FB0A6C2/fulltext/pdf

DOI: 10.1002/mds.10000

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ISTEX:597EDDD10BB7D74FDD91A0CF196FF2747FB0A6C2

Le document en format XML

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<front><div type="abstract" xml:lang="en">The bradykinesia associated with Parkinson's disease (PD) can be improved by both levodopa and the use of external cues. We examined the combined effect of levodopa and external cueing on the voluntary reaching movements of individuals with PD. Nine subjects with PD and nine matched controls were studied reaching to a ball target. Subjects with PD were studied after being off levodopa overnight and again on their morning dose. Kinematic data were collected as all subjects made both accurate and fast reaches under two different cue conditions: noncued (self‐initiated) and cued (triggered by a light). Subjects with PD reached more slowly than controls under all conditions. PD subjects increased their reach velocity and decreased movement time after taking levodopa and also when moving to a cue. However, the effects of levodopa and cueing were not additive. Instead, levodopa improved reach velocity to a greater extent in the noncued vs. cued condition. We also found that levodopa improved accurate (self‐paced) reaches more than fast reaches. These data suggest that levodopa may preferentially improve voluntary reaches that are more internally generated. © 2002 Movement Disorder Society.</div>
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<front><div type="abstract" xml:lang="en">The bradykinesia associated with Parkinson's disease (PD) can be improved by both levodopa and the use of external cues. We examined the combined effect of levodopa and external cueing on the voluntary reaching movements of individuals with PD. Nine subjects with PD and nine matched controls were studied reaching to a ball target. Subjects with PD were studied after being off levodopa overnight and again on their morning dose. Kinematic data were collected as all subjects made both accurate and fast reaches under two different cue conditions: noncued (self-initiated) and cued (triggered by a light). Subjects with PD reached more slowly than controls under all conditions. PD subjects increased their reach velocity and decreased movement time after taking levodopa and also when moving to a cue. However, the effects of levodopa and cueing were not additive. Instead, levodopa improved reach velocity to a greater extent in the noncued vs. cued condition. We also found that levodopa improved accurate (self-paced) reaches more than fast reaches. These data suggest that levodopa may preferentially improve voluntary reaches that are more internally generated.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Interaction of levodopa and cues on voluntary reaching in Parkinson's disease

Interaction of levodopa and cues on voluntary reaching in Parkinson's disease

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