Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease
Identifieur interne : 000353 ( Istex/Curation ); précédent : 000352; suivant : 000354Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease
Auteurs : Luc J. P. Defebvre [France] ; Pierre Krystkowiak [France] ; Jean-Louis Blatt [France] ; Alain Duhamel [France] ; Jean-Louis Bourriez [France] ; Myriame Périna [France] ; Serge Blond [France] ; Jean-Daniel Guieu [France] ; Alain Destée [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-01.
English descriptors
Abstract
In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off‐ and on‐drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L‐dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L‐dopa. GPi stimulation and L‐dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity, the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase. This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L‐dopa. © 2001 Movement Disorder Society.
Url:
DOI: 10.1002/mds.1262
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000353
Links to Exploration step
ISTEX:32AD527100BE5F9DBA677ED9752C9D1A2C8122ABLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease</title>
<author><name sortKey="Defebvre, Luc J P" sort="Defebvre, Luc J P" uniqKey="Defebvre L" first="Luc J. P." last="Defebvre">Luc J. P. Defebvre</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gait Analysis, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology and Movement Disorders Unit, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krystkowiak, Pierre" sort="Krystkowiak, Pierre" uniqKey="Krystkowiak P" first="Pierre" last="Krystkowiak">Pierre Krystkowiak</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gait Analysis, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology and Movement Disorders Unit, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blatt, Jean Ouis" sort="Blatt, Jean Ouis" uniqKey="Blatt J" first="Jean-Louis" last="Blatt">Jean-Louis Blatt</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gait Analysis, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neurophysiology, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Clinical Neurophysiology, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Medical Informatics, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Medical Informatics, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bourriez, Jean Ouis" sort="Bourriez, Jean Ouis" uniqKey="Bourriez J" first="Jean-Louis" last="Bourriez">Jean-Louis Bourriez</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gait Analysis, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neurophysiology, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Clinical Neurophysiology, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Perina, Myriame" sort="Perina, Myriame" uniqKey="Perina M" first="Myriame" last="Périna">Myriame Périna</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology and Movement Disorders Unit, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blond, Serge" sort="Blond, Serge" uniqKey="Blond S" first="Serge" last="Blond">Serge Blond</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gait Analysis, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurosurgery, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guieu, Jean Aniel" sort="Guieu, Jean Aniel" uniqKey="Guieu J" first="Jean-Daniel" last="Guieu">Jean-Daniel Guieu</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gait Analysis, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neurophysiology, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Clinical Neurophysiology, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gait Analysis, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology and Movement Disorders Unit, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:32AD527100BE5F9DBA677ED9752C9D1A2C8122AB</idno>
<date when="2002" year="2002">2002</date>
<idno type="doi">10.1002/mds.1262</idno>
<idno type="url">https://api.istex.fr/document/32AD527100BE5F9DBA677ED9752C9D1A2C8122AB/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000353</idno>
<idno type="wicri:Area/Istex/Curation">000353</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease</title>
<author><name sortKey="Defebvre, Luc J P" sort="Defebvre, Luc J P" uniqKey="Defebvre L" first="Luc J. P." last="Defebvre">Luc J. P. Defebvre</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gait Analysis, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology and Movement Disorders Unit, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krystkowiak, Pierre" sort="Krystkowiak, Pierre" uniqKey="Krystkowiak P" first="Pierre" last="Krystkowiak">Pierre Krystkowiak</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gait Analysis, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology and Movement Disorders Unit, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blatt, Jean Ouis" sort="Blatt, Jean Ouis" uniqKey="Blatt J" first="Jean-Louis" last="Blatt">Jean-Louis Blatt</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gait Analysis, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neurophysiology, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Clinical Neurophysiology, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Medical Informatics, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Medical Informatics, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bourriez, Jean Ouis" sort="Bourriez, Jean Ouis" uniqKey="Bourriez J" first="Jean-Louis" last="Bourriez">Jean-Louis Bourriez</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gait Analysis, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neurophysiology, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Clinical Neurophysiology, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Perina, Myriame" sort="Perina, Myriame" uniqKey="Perina M" first="Myriame" last="Périna">Myriame Périna</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology and Movement Disorders Unit, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blond, Serge" sort="Blond, Serge" uniqKey="Blond S" first="Serge" last="Blond">Serge Blond</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gait Analysis, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurosurgery, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guieu, Jean Aniel" sort="Guieu, Jean Aniel" uniqKey="Guieu J" first="Jean-Daniel" last="Guieu">Jean-Daniel Guieu</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gait Analysis, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Clinical Neurophysiology, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Clinical Neurophysiology, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Gait Analysis, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Gait Analysis, University of Lille, Lille</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology and Movement Disorders Unit, University of Lille, Lille</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>John Wiley & Sons, Inc.</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2002-01">2002-01</date>
<biblScope unit="vol">17</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="76">76</biblScope>
<biblScope unit="page" to="83">83</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">32AD527100BE5F9DBA677ED9752C9D1A2C8122AB</idno>
<idno type="DOI">10.1002/mds.1262</idno>
<idno type="ArticleID">MDS1262</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>L‐dopa</term>
<term>Parkinson's disease</term>
<term>gait</term>
<term>pallidal stimulation</term>
<term>preparatory postural adjustments</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off‐ and on‐drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L‐dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L‐dopa. GPi stimulation and L‐dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity, the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase. This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L‐dopa. © 2001 Movement Disorder Society.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000353 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000353 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:32AD527100BE5F9DBA677ED9752C9D1A2C8122AB |texte= Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.23. | ![]() |