MovDisordV3, PascalFrancis, Corpus, bibRecord, 002816

Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease

Identifieur interne : 002816 ( PascalFrancis/Corpus ); précédent : 002815; suivant : 002817

Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease

Auteurs : Luc J. P. Defebvre ; Pierre Krystkowiak ; Jean-Louis Blatt ; Alain Duhamel ; Jean-Louis Bourriez ; Myriame Perina ; Serge Blond ; Jean-Daniel Guieu ; Alain Destee

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:02-0207158

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Stimulus électrique, Pallidum, Lévodopa, Chimiothérapie, Antiparkinsonien, Equilibre, Marche à pied, Cinématique, Traitement instrumental, Pronostic, Adulte.

English descriptors

KwdEn :
- Adult, Antiparkinson agent, Chemotherapy, Electrical stimulus, Equilibrium, Instrumentation therapy, Kinematics, Levodopa, Pallidum, Parkinson disease, Prognosis, Walking.

Abstract

In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off- and on-drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L-dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L-dopa. GPi stimulation and L-dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L-dopa.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 DEFEBVRE (Luc J. P.)`
A11	`02`	`1`		`@1 KRYSTKOWIAK (Pierre)`
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C01	`01`		`ENG`	@0 In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off- and on-drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L-dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L-dopa. GPi stimulation and L-dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L-dopa.
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C03	`04`	`X`	`SPA`	`@0 Levodopa @2 NK @2 FR @5 07`
C03	`05`	`X`	`FRE`	`@0 Chimiothérapie @5 08`
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C03	`05`	`X`	`SPA`	`@0 Quimioterapia @5 08`
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C07	`02`	`X`	`FRE`	`@0 Système nerveux pathologie @5 37`
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Format Inist (serveur)

NO :	PASCAL 02-0207158 INIST
ET :	Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease
AU :	DEFEBVRE (Luc J. P.); KRYSTKOWIAK (Pierre); BLATT (Jean-Louis); DUHAMEL (Alain); BOURRIEZ (Jean-Louis); PERINA (Myriame); BLOND (Serge); GUIEU (Jean-Daniel); DESTEE (Alain)
AF :	Department of Gait Analysis, University of Lille/Lille/France (1 aut., 2 aut., 3 aut., 5 aut., 7 aut., 8 aut., 9 aut.); Department of Neurology and Movement Disorders Unit, University of Lille/Lille/France (1 aut., 2 aut., 6 aut., 9 aut.); Department of Clinical Neurophysiology, University of Lille/Lille/France (3 aut., 5 aut., 8 aut.); Department of Medical Informatics, University of Lille/Lille/France (4 aut.); Department of Neurosurgery, University of Lille/Lille/France (7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. 1; Pp. 76-83; Bibl. 22 ref.
LA :	Anglais
EA :	In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off- and on-drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L-dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L-dopa. GPi stimulation and L-dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L-dopa.
CC :	002B26I
FD :	Parkinson maladie; Stimulus électrique; Pallidum; Lévodopa; Chimiothérapie; Antiparkinsonien; Equilibre; Marche à pied; Cinématique; Traitement instrumental; Pronostic; Adulte
FG :	Homme; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Stimulation instrumentale
ED :	Parkinson disease; Electrical stimulus; Pallidum; Levodopa; Chemotherapy; Antiparkinson agent; Equilibrium; Walking; Kinematics; Instrumentation therapy; Prognosis; Adult
EG :	Human; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Instrumental stimulation
SD :	Parkinson enfermedad; Estímulo eléctrico; Pallidum; Levodopa; Quimioterapia; Antiparkinsoniano; Equilibrio; Caminata; Cinemática; Tratamiento instrumental; Pronóstico; Adulto
LO :	INIST-20953.354000100147290120
ID :	02-0207158

Links to Exploration step

Pascal:02-0207158

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease</title>
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<author><name sortKey="Blond, Serge" sort="Blond, Serge" uniqKey="Blond S" first="Serge" last="Blond">Serge Blond</name>
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<sZ>7 aut.</sZ>
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<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destee">Alain Destee</name>
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<s2>Lille</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<sZ>8 aut.</sZ>
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<series><title level="j" type="main">Movement disorders</title>
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<term>Antiparkinson agent</term>
<term>Chemotherapy</term>
<term>Electrical stimulus</term>
<term>Equilibrium</term>
<term>Instrumentation therapy</term>
<term>Kinematics</term>
<term>Levodopa</term>
<term>Pallidum</term>
<term>Parkinson disease</term>
<term>Prognosis</term>
<term>Walking</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Stimulus électrique</term>
<term>Pallidum</term>
<term>Lévodopa</term>
<term>Chimiothérapie</term>
<term>Antiparkinsonien</term>
<term>Equilibre</term>
<term>Marche à pied</term>
<term>Cinématique</term>
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<front><div type="abstract" xml:lang="en">In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off- and on-drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L-dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L-dopa. GPi stimulation and L-dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L-dopa.</div>
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</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>01</s5>
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<s5>04</s5>
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<s5>05</s5>
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<s2>FR</s2>
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<fC03 i1="04" i2="X" l="ENG"><s0>Levodopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Levodopa</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Chimiothérapie</s0>
<s5>08</s5>
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<fC03 i1="05" i2="X" l="ENG"><s0>Chemotherapy</s0>
<s5>08</s5>
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<fC03 i1="10" i2="X" l="SPA"><s0>Tratamiento instrumental</s0>
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<s5>18</s5>
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<s5>40</s5>
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<s5>40</s5>
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<server><NO>PASCAL 02-0207158 INIST</NO>
<ET>Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease</ET>
<AU>DEFEBVRE (Luc J. P.); KRYSTKOWIAK (Pierre); BLATT (Jean-Louis); DUHAMEL (Alain); BOURRIEZ (Jean-Louis); PERINA (Myriame); BLOND (Serge); GUIEU (Jean-Daniel); DESTEE (Alain)</AU>
<AF>Department of Gait Analysis, University of Lille/Lille/France (1 aut., 2 aut., 3 aut., 5 aut., 7 aut., 8 aut., 9 aut.); Department of Neurology and Movement Disorders Unit, University of Lille/Lille/France (1 aut., 2 aut., 6 aut., 9 aut.); Department of Clinical Neurophysiology, University of Lille/Lille/France (3 aut., 5 aut., 8 aut.); Department of Medical Informatics, University of Lille/Lille/France (4 aut.); Department of Neurosurgery, University of Lille/Lille/France (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2002; Vol. 17; No. 1; Pp. 76-83; Bibl. 22 ref.</SO>
<LA>Anglais</LA>
<EA>In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off- and on-drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L-dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L-dopa. GPi stimulation and L-dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L-dopa.</EA>
<CC>002B26I</CC>
<FD>Parkinson maladie; Stimulus électrique; Pallidum; Lévodopa; Chimiothérapie; Antiparkinsonien; Equilibre; Marche à pied; Cinématique; Traitement instrumental; Pronostic; Adulte</FD>
<FG>Homme; Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Stimulation instrumentale</FG>
<ED>Parkinson disease; Electrical stimulus; Pallidum; Levodopa; Chemotherapy; Antiparkinson agent; Equilibrium; Walking; Kinematics; Instrumentation therapy; Prognosis; Adult</ED>
<EG>Human; Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Instrumental stimulation</EG>
<SD>Parkinson enfermedad; Estímulo eléctrico; Pallidum; Levodopa; Quimioterapia; Antiparkinsoniano; Equilibrio; Caminata; Cinemática; Tratamiento instrumental; Pronóstico; Adulto</SD>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease

Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease

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