Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease
Identifieur interne : 000353 ( Istex/Corpus ); précédent : 000352; suivant : 000354Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease
Auteurs : Luc J. P. Defebvre ; Pierre Krystkowiak ; Jean-Louis Blatt ; Alain Duhamel ; Jean-Louis Bourriez ; Myriame Périna ; Serge Blond ; Jean-Daniel Guieu ; Alain DestéeSource :
- Movement Disorders [ 0885-3185 ] ; 2002-01.
English descriptors
Abstract
In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off‐ and on‐drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L‐dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L‐dopa. GPi stimulation and L‐dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity, the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase. This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L‐dopa. © 2001 Movement Disorder Society.
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DOI: 10.1002/mds.1262
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Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L‐dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L‐dopa. GPi stimulation and L‐dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity, the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase. This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L‐dopa. © 2001 Movement Disorder Society.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Luc J.P. Defebvre MD, PhD</name><affiliations><json:string>Department of Gait Analysis, University of Lille, Lille, France</json:string><json:string>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</json:string></affiliations></json:item><json:item><name>Pierre Krystkowiak MD</name><affiliations><json:string>Department of Gait Analysis, University of Lille, Lille, France</json:string><json:string>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</json:string></affiliations></json:item><json:item><name>Jean‐Louis Blatt MD, PhD</name><affiliations><json:string>Department of Gait Analysis, University of Lille, Lille, France</json:string><json:string>Department of Clinical Neurophysiology, University of Lille, Lille, France</json:string></affiliations></json:item><json:item><name>Alain Duhamel PhD</name><affiliations><json:string>Department of Medical Informatics, University of Lille, Lille, France</json:string></affiliations></json:item><json:item><name>Jean‐Louis Bourriez PhD</name><affiliations><json:string>Department of Gait Analysis, University of Lille, Lille, France</json:string><json:string>Department of Clinical Neurophysiology, University of Lille, Lille, France</json:string></affiliations></json:item><json:item><name>Myriame Périna MD</name><affiliations><json:string>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</json:string></affiliations></json:item><json:item><name>Serge Blond MD</name><affiliations><json:string>Department of Gait Analysis, University of Lille, Lille, France</json:string><json:string>Department of Neurosurgery, University of Lille, Lille, France</json:string></affiliations></json:item><json:item><name>Jean‐Daniel Guieu MD</name><affiliations><json:string>Department of Gait Analysis, University of Lille, Lille, France</json:string><json:string>Department of Clinical Neurophysiology, University of Lille, Lille, France</json:string></affiliations></json:item><json:item><name>Alain Destée MD</name><affiliations><json:string>Department of Gait Analysis, University of Lille, Lille, France</json:string><json:string>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>L‐dopa</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pallidal stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>gait</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>preparatory postural adjustments</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item></subject><language><json:string>eng</json:string></language><abstract>In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off‐ and on‐drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L‐dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L‐dopa. GPi stimulation and L‐dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity, the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase. 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Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L‐dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L‐dopa. GPi stimulation and L‐dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity, the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase. This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L‐dopa. © 2001 Movement Disorder Society.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>L‐dopa</term></item><item><term>pallidal stimulation</term></item><item><term>gait</term></item><item><term>preparatory postural adjustments</term></item><item><term>Parkinson's disease</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2000-08-17">Received</change><change when="2001-06-11">Registration</change><change when="2002-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/32AD527100BE5F9DBA677ED9752C9D1A2C8122AB/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Inc.</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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France.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS1262.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="6"></count><count type="referenceTotal" number="22"></count><count type="wordTotal" number="4704"></count></countGroup><titleGroup><title type="main" xml:lang="en">Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease</title><title type="short" xml:lang="en">Gait and Postural Instability with GPi Stimulation</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Luc J.P.</givenNames><familyName>Defebvre</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email normalForm="Ldefebvre@chru-lille.fr">Ldefebvre@chru‐lille.fr</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Pierre</givenNames><familyName>Krystkowiak</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Jean‐Louis</givenNames><familyName>Blatt</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Alain</givenNames><familyName>Duhamel</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Jean‐Louis</givenNames><familyName>Bourriez</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Myriame</givenNames><familyName>Périna</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1 #af5"><personName><givenNames>Serge</givenNames><familyName>Blond</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Jean‐Daniel</givenNames><familyName>Guieu</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Alain</givenNames><familyName>Destée</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Department of Gait Analysis, University of Lille, Lille, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="FR" type="organization"><unparsedAffiliation>Department of Clinical Neurophysiology, University of Lille, Lille, France</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="FR" type="organization"><unparsedAffiliation>Department of Medical Informatics, University of Lille, Lille, France</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="FR" type="organization"><unparsedAffiliation>Department of Neurosurgery, University of Lille, Lille, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1"><sc>L</sc>‐dopa</keyword><keyword xml:id="kwd2">pallidal stimulation</keyword><keyword xml:id="kwd3">gait</keyword><keyword xml:id="kwd4">preparatory postural adjustments</keyword><keyword xml:id="kwd5">Parkinson's disease</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in <i>off</i>‐ and <i>on</i>‐drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (<sc>L</sc>‐dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by <sc>L</sc>‐dopa. GPi stimulation and <sc>L</sc>‐dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity, the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase. This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than <sc>L</sc>‐dopa. © 2001 Movement Disorder Society.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Gait and Postural Instability with GPi Stimulation</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Luc J.P.</namePart><namePart type="family">Defebvre</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Gait Analysis, University of Lille, Lille, France</affiliation><affiliation>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</affiliation><description>Correspondence: Service de Neurologie et Pathologie du Mouvement, Hôpital Salengro, CHRU. 59037 Lille, Cedex. France.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierre</namePart><namePart type="family">Krystkowiak</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Gait Analysis, University of Lille, Lille, France</affiliation><affiliation>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Louis</namePart><namePart type="family">Blatt</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Gait Analysis, University of Lille, Lille, France</affiliation><affiliation>Department of Clinical Neurophysiology, University of Lille, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alain</namePart><namePart type="family">Duhamel</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Medical Informatics, University of Lille, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Louis</namePart><namePart type="family">Bourriez</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Gait Analysis, University of Lille, Lille, France</affiliation><affiliation>Department of Clinical Neurophysiology, University of Lille, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Myriame</namePart><namePart type="family">Périna</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Serge</namePart><namePart type="family">Blond</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Gait Analysis, University of Lille, Lille, France</affiliation><affiliation>Department of Neurosurgery, University of Lille, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Daniel</namePart><namePart type="family">Guieu</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Gait Analysis, University of Lille, Lille, France</affiliation><affiliation>Department of Clinical Neurophysiology, University of Lille, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alain</namePart><namePart type="family">Destée</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Gait Analysis, University of Lille, Lille, France</affiliation><affiliation>Department of Neurology and Movement Disorders Unit, University of Lille, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2002-01</dateIssued><dateCaptured encoding="w3cdtf">2000-08-17</dateCaptured><dateValid encoding="w3cdtf">2001-06-11</dateValid><copyrightDate encoding="w3cdtf">2002</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">6</extent><extent unit="references">22</extent><extent unit="words">4704</extent></physicalDescription><abstract lang="en">In order to assess the influence of the bilateral internal globus pallidus (GPi) stimulation on gait and postural instability in Parkinson's disease (PD), we compared gait kinematic parameters and preparatory postural adjustments before and 3 months after stimulation in off‐ and on‐drug conditions for seven patients. Gait kinematic parameters and displacements of centre of pressure (CP) and shoulder computed before a lateral raising task of the leg, were recorded using optoelectric Vicon system. Levodopa (L‐dopa) induced a clear benefit for gait velocity (related to an increase of stride length) and also an increase of swing phase duration. GPi stimulation had a limited effect, since the increase of gait velocity was induced by a concomitant increase of stride length and cadence corresponding to a compensatory mechanism. The benefit on swing phase duration was also moderate. Displacements of CP were improved mainly by L‐dopa. GPi stimulation and L‐dopa had the same beneficial effect on the speed at which the CP was transferred back towards the support side, the ankle velocity, the onset time for ankle displacement, and the decrease of shoulder amplitude towards the support side, which reflects a better postural adjustment phase. This study, based on an objective method, revealed that chronic bilateral GPi stimulation may improve gait and preparatory postural adjustments in severe PD patients with a more limited effect than L‐dopa. © 2001 Movement Disorder Society.</abstract><subject lang="en"><genre>Keywords</genre><topic>L‐dopa</topic><topic>pallidal stimulation</topic><topic>gait</topic><topic>preparatory postural adjustments</topic><topic>Parkinson's disease</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. 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