MovDisordV3, Main, Curation, bibRecord, 003202

Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure

Identifieur interne : 003202 ( Main/Curation ); précédent : 003201; suivant : 003203

Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure

Auteurs : Annu Aggarwal [Inde] ; Sachin Vaidya [Inde] ; Samir Shah [Inde] ; Joshita Singh [Inde] ; Shrinivas Desai [Inde] ; Mohit Bhatt [Inde]

Source :

Movement Disorders [ 0885-3185 ] ; 2006-11.

RBID : ISTEX:7E95A71219645ABC9C0E0ACE011E0162EE675338

Descripteurs français

Pascal (Inist)
- Hyperintensité, Insuffisance hépatique, Manganèse, Parkinsonisme, Système nerveux pathologie.
Wicri :
- topic : Manganèse.

English descriptors

KwdEn :
- Adult, Antiparkinson Agents (adverse effects), Female, Globus Pallidus (pathology), Humans, Hyperintensity, Levodopa (adverse effects), Liver Failure, Acute (complications), Liver Failure, Acute (pathology), Liver failure, Magnetic Resonance Imaging, Manganese, Nervous system diseases, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (pathology), Parkinsonian Disorders (drug therapy), Parkinsonian Disorders (etiology), Parkinsonian Disorders (pathology), Parkinsonism, T1W pallidal hyperintensities, acute liver failure, manganese, reversible Parkinsonism.
MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemically induced : Parkinson Disease, Secondary.
- complications : Liver Failure, Acute.
- drug therapy : Parkinsonian Disorders.
- etiology : Parkinsonian Disorders.
- pathology : Globus Pallidus, Liver Failure, Acute, Parkinson Disease, Secondary, Parkinsonian Disorders.
- Adult, Female, Humans, Magnetic Resonance Imaging.

Abstract

We report on a young woman who survived acute liver failure (ALF) without liver transplant. During the ALF, she developed a disabling, levodopa‐unresponsive, symmetrical Parkinsonism. This was characterized by severe bradykinesia, mild rigidity, mutism, and prominent gait impairment. Magnetic resonance imaging (MRI) showed bilateral T1W pallidal hyperintensities. Parkinsonism and MRI changes remitted in parallel with normalization of hepatic function. We implicate excessive pallidal manganese deposition secondary to ALF in the pathogenesis of this neuroradiological syndrome. Though hitherto unreported, we propose that Parkinsonism with T1W pallidal hyperintensities may not be uncommon in ALF. © 2006 Movement Disorder Society

Url:

https://api.istex.fr/document/7E95A71219645ABC9C0E0ACE011E0162EE675338/fulltext/pdf

DOI: 10.1002/mds.21096

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ISTEX:7E95A71219645ABC9C0E0ACE011E0162EE675338

Le document en format XML

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<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure</title>
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<wicri:regionArea>Movement Disorder Clinic, Department of Neurology, Jaslok Hospital and Research Centre, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
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<affiliation wicri:level="1"><country xml:lang="fr">Inde</country>
<wicri:regionArea>Movement Disorder Clinic, Department of Neurology, Jaslok Hospital and Research Centre, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shah, Samir" sort="Shah, Samir" uniqKey="Shah S" first="Samir" last="Shah">Samir Shah</name>
<affiliation wicri:level="1"><country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Gastroenterology, Jaslok Hospital and Research Centre, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Singh, Joshita" sort="Singh, Joshita" uniqKey="Singh J" first="Joshita" last="Singh">Joshita Singh</name>
<affiliation wicri:level="1"><country xml:lang="fr">Inde</country>
<wicri:regionArea>Department of Neuroradiology, Jaslok Hospital and Research Centre, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Desai, Shrinivas" sort="Desai, Shrinivas" uniqKey="Desai S" first="Shrinivas" last="Desai">Shrinivas Desai</name>
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<wicri:noRegion>Mumbai</wicri:noRegion>
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<author><name sortKey="Bhatt, Mohit" sort="Bhatt, Mohit" uniqKey="Bhatt M" first="Mohit" last="Bhatt">Mohit Bhatt</name>
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<wicri:regionArea>Movement Disorder Clinic, Department of Neurology, Jaslok Hospital and Research Centre, Mumbai</wicri:regionArea>
<wicri:noRegion>Mumbai</wicri:noRegion>
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<series><title level="j">Movement Disorders</title>
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<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
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<pubPlace>Hoboken</pubPlace>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Female</term>
<term>Globus Pallidus (pathology)</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
<term>Liver Failure, Acute (complications)</term>
<term>Liver Failure, Acute (pathology)</term>
<term>Magnetic Resonance Imaging</term>
<term>Parkinson Disease, Secondary (chemically induced)</term>
<term>Parkinson Disease, Secondary (pathology)</term>
<term>Parkinsonian Disorders (drug therapy)</term>
<term>Parkinsonian Disorders (etiology)</term>
<term>Parkinsonian Disorders (pathology)</term>
<term>T1W pallidal hyperintensities</term>
<term>acute liver failure</term>
<term>manganese</term>
<term>reversible Parkinsonism</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Liver Failure, Acute</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Globus Pallidus</term>
<term>Liver Failure, Acute</term>
<term>Parkinson Disease, Secondary</term>
<term>Parkinsonian Disorders</term>
</keywords>
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<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
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<front><div type="abstract" xml:lang="en">We report on a young woman who survived acute liver failure (ALF) without liver transplant. During the ALF, she developed a disabling, levodopa‐unresponsive, symmetrical Parkinsonism. This was characterized by severe bradykinesia, mild rigidity, mutism, and prominent gait impairment. Magnetic resonance imaging (MRI) showed bilateral T1W pallidal hyperintensities. Parkinsonism and MRI changes remitted in parallel with normalization of hepatic function. We implicate excessive pallidal manganese deposition secondary to ALF in the pathogenesis of this neuroradiological syndrome. Though hitherto unreported, we propose that Parkinsonism with T1W pallidal hyperintensities may not be uncommon in ALF. © 2006 Movement Disorder Society</div>
</front>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure

Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure

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