Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure
Identifieur interne : 002F20 ( Istex/Corpus ); précédent : 002F19; suivant : 002F21Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure
Auteurs : Annu Aggarwal ; Sachin Vaidya ; Samir Shah ; Joshita Singh ; Shrinivas Desai ; Mohit BhattSource :
- Movement Disorders [ 0885-3185 ] ; 2006-11.
English descriptors
Abstract
We report on a young woman who survived acute liver failure (ALF) without liver transplant. During the ALF, she developed a disabling, levodopa‐unresponsive, symmetrical Parkinsonism. This was characterized by severe bradykinesia, mild rigidity, mutism, and prominent gait impairment. Magnetic resonance imaging (MRI) showed bilateral T1W pallidal hyperintensities. Parkinsonism and MRI changes remitted in parallel with normalization of hepatic function. We implicate excessive pallidal manganese deposition secondary to ALF in the pathogenesis of this neuroradiological syndrome. Though hitherto unreported, we propose that Parkinsonism with T1W pallidal hyperintensities may not be uncommon in ALF. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21096
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<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Samir</namePart>
<namePart type="family">Shah</namePart>
<namePart type="termsOfAddress">DM</namePart>
<affiliation>Department of Gastroenterology, Jaslok Hospital and Research Centre, Mumbai, India</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Joshita</namePart>
<namePart type="family">Singh</namePart>
<namePart type="termsOfAddress">DNB</namePart>
<affiliation>Department of Neuroradiology, Jaslok Hospital and Research Centre, Mumbai, India</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Shrinivas</namePart>
<namePart type="family">Desai</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neuroradiology, Jaslok Hospital and Research Centre, Mumbai, India</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Mohit</namePart>
<namePart type="family">Bhatt</namePart>
<namePart type="termsOfAddress">DM</namePart>
<affiliation>Movement Disorder Clinic, Department of Neurology, Jaslok Hospital and Research Centre, Mumbai, India</affiliation>
<description>Correspondence: Movement Disorder Clinic, 12th Floor, Jaslok Hospital and Research Center, Pedder Road, Mumbai 400026, India</description>
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<originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<place><placeTerm type="text">Hoboken</placeTerm>
</place>
<dateIssued encoding="w3cdtf">2006-11</dateIssued>
<dateCaptured encoding="w3cdtf">2006-02-28</dateCaptured>
<dateValid encoding="w3cdtf">2006-05-20</dateValid>
<copyrightDate encoding="w3cdtf">2006</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
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<extent unit="figures">2</extent>
<extent unit="tables">2</extent>
<extent unit="references">17</extent>
<extent unit="words">2238</extent>
</physicalDescription>
<abstract lang="en">We report on a young woman who survived acute liver failure (ALF) without liver transplant. During the ALF, she developed a disabling, levodopa‐unresponsive, symmetrical Parkinsonism. This was characterized by severe bradykinesia, mild rigidity, mutism, and prominent gait impairment. Magnetic resonance imaging (MRI) showed bilateral T1W pallidal hyperintensities. Parkinsonism and MRI changes remitted in parallel with normalization of hepatic function. We implicate excessive pallidal manganese deposition secondary to ALF in the pathogenesis of this neuroradiological syndrome. Though hitherto unreported, we propose that Parkinsonism with T1W pallidal hyperintensities may not be uncommon in ALF. © 2006 Movement Disorder Society</abstract>
<subject lang="en"><genre>Keywords</genre>
<topic>reversible Parkinsonism</topic>
<topic>T1W pallidal hyperintensities</topic>
<topic>manganese</topic>
<topic>acute liver failure</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Movement Disorders</title>
<subTitle>Official Journal of the Movement Disorder Society</subTitle>
</titleInfo>
<titleInfo type="abbreviated"><title>Mov. Disord.</title>
</titleInfo>
<subject><genre>article category</genre>
<topic>Brief Report</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>21</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>11</number>
</detail>
<extent unit="pages"><start>1986</start>
<end>1990</end>
<total>4</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">7E95A71219645ABC9C0E0ACE011E0162EE675338</identifier>
<identifier type="DOI">10.1002/mds.21096</identifier>
<identifier type="ArticleID">MDS21096</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 Movement Disorder Society</accessCondition>
<recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin>
<recordContentSource>WILEY</recordContentSource>
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