Movement Disorders (revue)

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Reversible parkinsonism and T1W pallidal hyperintensities in acute liver failure

Identifieur interne : 001422 ( PascalFrancis/Curation ); précédent : 001421; suivant : 001423

Reversible parkinsonism and T1W pallidal hyperintensities in acute liver failure

Auteurs : Annu Aggarwal [Inde] ; Sachin Vaidya [Inde] ; Samir Shah [Inde] ; Joshita Singh [Inde] ; Shrinivas Desai [Inde] ; Mohit Bhatt [Inde]

Source :

RBID : Pascal:07-0021732

Descripteurs français

English descriptors

Abstract

We report on a young woman who survived acute liver failure (ALF) without liver transplant. During the ALF, she developed a disabling, levodopa-unresponsive, symmetrical Parkinsonism. This was characterized by severe bradykinesia, mild rigidity, mutism, and prominent gait impairment. Magnetic resonance imaging (MRI) showed bilateral T1W pallidal hyperintensities. Parkinsonism and MRI changes remitted in parallel with normalization of hepatic function. We implicate excessive pallidal manganese deposition secondary to ALF in the pathogenesis of this neuroradiological syndrome. Though hitherto unreported, we propose that Parkinsonism with T1W pallidal hyperintensities may not be uncommon in ALF.
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A08 01  1  ENG  @1 Reversible parkinsonism and T1W pallidal hyperintensities in acute liver failure
A11 01  1    @1 AGGARWAL (Annu)
A11 02  1    @1 VAIDYA (Sachin)
A11 03  1    @1 SHAH (Samir)
A11 04  1    @1 SINGH (Joshita)
A11 05  1    @1 DESAI (Shrinivas)
A11 06  1    @1 BHATT (Mohit)
A14 01      @1 Movement Disorder Clinic, Department of Neurology, Jaslok Hospital and Research Centre @2 Mumbai @3 IND @Z 1 aut. @Z 2 aut. @Z 6 aut.
A14 02      @1 Department of Gastroenterology, Jaslok Hospital and Research Centre @2 Mumbai @3 IND @Z 3 aut.
A14 03      @1 Department of Neuroradiology, Jaslok Hospital and Research Centre @2 Mumbai @3 IND @Z 4 aut. @Z 5 aut.
A20       @1 1986-1990
A21       @1 2006
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A44       @0 0000 @1 © 2007 INIST-CNRS. All rights reserved.
A45       @0 17 ref.
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A60       @1 P @3 CC
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C01 01    ENG  @0 We report on a young woman who survived acute liver failure (ALF) without liver transplant. During the ALF, she developed a disabling, levodopa-unresponsive, symmetrical Parkinsonism. This was characterized by severe bradykinesia, mild rigidity, mutism, and prominent gait impairment. Magnetic resonance imaging (MRI) showed bilateral T1W pallidal hyperintensities. Parkinsonism and MRI changes remitted in parallel with normalization of hepatic function. We implicate excessive pallidal manganese deposition secondary to ALF in the pathogenesis of this neuroradiological syndrome. Though hitherto unreported, we propose that Parkinsonism with T1W pallidal hyperintensities may not be uncommon in ALF.
C02 01  X    @0 002B17
C02 02  X    @0 002B17G
C02 03  X    @0 002B02G
C03 01  X  FRE  @0 Système nerveux pathologie @5 01
C03 01  X  ENG  @0 Nervous system diseases @5 01
C03 01  X  SPA  @0 Sistema nervioso patología @5 01
C03 02  X  FRE  @0 Parkinsonisme @2 NM @5 02
C03 02  X  ENG  @0 Parkinsonism @2 NM @5 02
C03 02  X  SPA  @0 Parkinson síndrome @2 NM @5 02
C03 03  X  FRE  @0 Insuffisance hépatique @5 03
C03 03  X  ENG  @0 Liver failure @5 03
C03 03  X  SPA  @0 Insuficiencia hepática @5 03
C03 04  X  FRE  @0 Hyperintensité @5 09
C03 04  X  ENG  @0 Hyperintensity @5 09
C03 04  X  SPA  @0 Hyperintensidad @5 09
C03 05  X  FRE  @0 Manganèse @2 NC @5 10
C03 05  X  ENG  @0 Manganese @2 NC @5 10
C03 05  X  SPA  @0 Manganeso @2 NC @5 10
C07 01  X  FRE  @0 Appareil digestif pathologie @5 37
C07 01  X  ENG  @0 Digestive diseases @5 37
C07 01  X  SPA  @0 Aparato digestivo patología @5 37
C07 02  X  FRE  @0 Foie pathologie @5 38
C07 02  X  ENG  @0 Hepatic disease @5 38
C07 02  X  SPA  @0 Hígado patología @5 38
N21       @1 010
N44 01      @1 OTO
N82       @1 OTO

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