Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure.
Identifieur interne : 002A80 ( PubMed/Corpus ); précédent : 002A79; suivant : 002A81Reversible Parkinsonism and T1W pallidal hyperintensities in acute liver failure.
Auteurs : Annu Aggarwal ; Sachin Vaidya ; Samir Shah ; Joshita Singh ; Shrinivas Desai ; Mohit BhattSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Adult, Antiparkinson Agents (adverse effects), Female, Globus Pallidus (pathology), Humans, Levodopa (adverse effects), Liver Failure, Acute (complications), Liver Failure, Acute (pathology), Magnetic Resonance Imaging, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (pathology), Parkinsonian Disorders (drug therapy), Parkinsonian Disorders (etiology), Parkinsonian Disorders (pathology).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemically induced : Parkinson Disease, Secondary.
- complications : Liver Failure, Acute.
- drug therapy : Parkinsonian Disorders.
- etiology : Parkinsonian Disorders.
- pathology : Globus Pallidus, Liver Failure, Acute, Parkinson Disease, Secondary, Parkinsonian Disorders.
- Adult, Female, Humans, Magnetic Resonance Imaging.
Abstract
We report on a young woman who survived acute liver failure (ALF) without liver transplant. During the ALF, she developed a disabling, levodopa-unresponsive, symmetrical Parkinsonism. This was characterized by severe bradykinesia, mild rigidity, mutism, and prominent gait impairment. Magnetic resonance imaging (MRI) showed bilateral T1W pallidal hyperintensities. Parkinsonism and MRI changes remitted in parallel with normalization of hepatic function. We implicate excessive pallidal manganese deposition secondary to ALF in the pathogenesis of this neuroradiological syndrome. Though hitherto unreported, we propose that Parkinsonism with T1W pallidal hyperintensities may not be uncommon in ALF.
DOI: 10.1002/mds.21096
PubMed: 16991145
Links to Exploration step
pubmed:16991145Le document en format XML
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<author><name sortKey="Aggarwal, Annu" sort="Aggarwal, Annu" uniqKey="Aggarwal A" first="Annu" last="Aggarwal">Annu Aggarwal</name>
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<author><name sortKey="Vaidya, Sachin" sort="Vaidya, Sachin" uniqKey="Vaidya S" first="Sachin" last="Vaidya">Sachin Vaidya</name>
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<author><name sortKey="Shah, Samir" sort="Shah, Samir" uniqKey="Shah S" first="Samir" last="Shah">Samir Shah</name>
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<author><name sortKey="Singh, Joshita" sort="Singh, Joshita" uniqKey="Singh J" first="Joshita" last="Singh">Joshita Singh</name>
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<author><name sortKey="Desai, Shrinivas" sort="Desai, Shrinivas" uniqKey="Desai S" first="Shrinivas" last="Desai">Shrinivas Desai</name>
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<author><name sortKey="Bhatt, Mohit" sort="Bhatt, Mohit" uniqKey="Bhatt M" first="Mohit" last="Bhatt">Mohit Bhatt</name>
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<author><name sortKey="Shah, Samir" sort="Shah, Samir" uniqKey="Shah S" first="Samir" last="Shah">Samir Shah</name>
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<author><name sortKey="Desai, Shrinivas" sort="Desai, Shrinivas" uniqKey="Desai S" first="Shrinivas" last="Desai">Shrinivas Desai</name>
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<term>Antiparkinson Agents (adverse effects)</term>
<term>Female</term>
<term>Globus Pallidus (pathology)</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
<term>Liver Failure, Acute (complications)</term>
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<term>Magnetic Resonance Imaging</term>
<term>Parkinson Disease, Secondary (chemically induced)</term>
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<term>Parkinsonian Disorders (drug therapy)</term>
<term>Parkinsonian Disorders (etiology)</term>
<term>Parkinsonian Disorders (pathology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
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<term>Liver Failure, Acute</term>
<term>Parkinson Disease, Secondary</term>
<term>Parkinsonian Disorders</term>
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<front><div type="abstract" xml:lang="en">We report on a young woman who survived acute liver failure (ALF) without liver transplant. During the ALF, she developed a disabling, levodopa-unresponsive, symmetrical Parkinsonism. This was characterized by severe bradykinesia, mild rigidity, mutism, and prominent gait impairment. Magnetic resonance imaging (MRI) showed bilateral T1W pallidal hyperintensities. Parkinsonism and MRI changes remitted in parallel with normalization of hepatic function. We implicate excessive pallidal manganese deposition secondary to ALF in the pathogenesis of this neuroradiological syndrome. Though hitherto unreported, we propose that Parkinsonism with T1W pallidal hyperintensities may not be uncommon in ALF.</div>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<Abstract><AbstractText>We report on a young woman who survived acute liver failure (ALF) without liver transplant. During the ALF, she developed a disabling, levodopa-unresponsive, symmetrical Parkinsonism. This was characterized by severe bradykinesia, mild rigidity, mutism, and prominent gait impairment. Magnetic resonance imaging (MRI) showed bilateral T1W pallidal hyperintensities. Parkinsonism and MRI changes remitted in parallel with normalization of hepatic function. We implicate excessive pallidal manganese deposition secondary to ALF in the pathogenesis of this neuroradiological syndrome. Though hitherto unreported, we propose that Parkinsonism with T1W pallidal hyperintensities may not be uncommon in ALF.</AbstractText>
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