Are parkin patients particularly suited for deep‐brain stimulation?
Identifieur interne : 002994 ( Main/Curation ); précédent : 002993; suivant : 002995Are parkin patients particularly suited for deep‐brain stimulation?
Auteurs : Ebba Lohmann [France] ; Marie-Laure Welter [France] ; Valérie Fraix [France] ; Paul Krack [France] ; Suzanne Lesage [France] ; Sophie Laine [France] ; Marie-Laure Tanguy [France] ; Jean-Luc Houeto [France] ; Valérie Mesnage [France] ; Pierre Pollak [France] ; Alexandra Durr [France] ; Yves Agid [France] ; Alexis Brice [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-04-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), DNA Mutational Analysis, Deep Brain Stimulation, Deep brain stimulation, Dyskinesia, Drug-Induced, Female, Follow-Up Studies, Genetic Testing, Heterozygote, Homozygote, Human, Humans, Levodopa (adverse effects), Levodopa (therapeutic use), Male, Middle Aged, Mutation, Nervous system diseases, Parkin, Parkinson disease, Parkinsonian Disorders (genetics), Parkinsonian Disorders (therapy), Parkinsonism, Treatment Outcome, Ubiquitin-Protein Ligases (genetics), deep brain stimulation, early‐onset Parkinsonism, parkin.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , genetics : Ubiquitin-Protein Ligases.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- genetics : Parkinsonian Disorders.
- therapy : Parkinsonian Disorders.
- Adult, Aged, DNA Mutational Analysis, Deep Brain Stimulation, Dyskinesia, Drug-Induced, Female, Follow-Up Studies, Genetic Testing, Heterozygote, Homozygote, Humans, Male, Middle Aged, Mutation, Treatment Outcome.
Abstract
Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow‐up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results. © 2008 Movement Disorder Society
Url:
- https://api.istex.fr/document/4459CC74F45A00448CC0C08EE9BB433983021C4F/fulltext/pdf
- http://www.hal.inserm.fr/inserm-00391529
DOI: 10.1002/mds.21903
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>DNA Mutational Analysis</term>
<term>Deep Brain Stimulation</term>
<term>Deep brain stimulation</term>
<term>Dyskinesia, Drug-Induced</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genetic Testing</term>
<term>Heterozygote</term>
<term>Homozygote</term>
<term>Human</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Nervous system diseases</term>
<term>Parkin</term>
<term>Parkinson disease</term>
<term>Parkinsonian Disorders (genetics)</term>
<term>Parkinsonian Disorders (therapy)</term>
<term>Parkinsonism</term>
<term>Treatment Outcome</term>
<term>Ubiquitin-Protein Ligases (genetics)</term>
<term>deep brain stimulation</term>
<term>early‐onset Parkinsonism</term>
<term>parkin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Ubiquitin-Protein Ligases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>DNA Mutational Analysis</term>
<term>Deep Brain Stimulation</term>
<term>Dyskinesia, Drug-Induced</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genetic Testing</term>
<term>Heterozygote</term>
<term>Homozygote</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Homme</term>
<term>Maladie de Parkinson</term>
<term>Parkine</term>
<term>Parkinsonisme</term>
<term>Pathologie du système nerveux</term>
<term>Stimulation cérébrale profonde</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow‐up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results. © 2008 Movement Disorder Society</div>
</front>
</TEI>
<double idat="0885-3185:2008:Lohmann E:are:parkin:patients"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Are Parkin Patients Particularly Suited for Deep-Brain Stimulation?</title>
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</author>
<author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
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<author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name>
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<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
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<author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
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<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pierre and Marie Curie-Paris6 University, UMR S679, Pitié-Salpêtrière Hospital</s1>
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<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Federative Institute for Neuroscience Research (IFR70), Pitié-Salpêtrière Hospital</s1>
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</inist:fA14>
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<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Laine, Sophie" sort="Laine, Sophie" uniqKey="Laine S" first="Sophie" last="Laine">Sophie Laine</name>
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</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pierre and Marie Curie-Paris6 University, UMR S679, Pitié-Salpêtrière Hospital</s1>
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</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Federative Institute for Neuroscience Research (IFR70), Pitié-Salpêtrière Hospital</s1>
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<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tanguy, Marie Laure" sort="Tanguy, Marie Laure" uniqKey="Tanguy M" first="Marie-Laure" last="Tanguy">Marie-Laure Tanguy</name>
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<s3>FRA</s3>
<sZ>7 aut.</sZ>
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</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
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<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>CHU Poitiers</wicri:noRegion>
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</affiliation>
</author>
<author><name sortKey="Mesnage, Valerie" sort="Mesnage, Valerie" uniqKey="Mesnage V" first="Valérie" last="Mesnage">Valérie Mesnage</name>
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<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Département de Neurologie, CHU Grenoble</s1>
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<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName>
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<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
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</placeName>
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</affiliation>
</author>
<author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name>
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</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pierre and Marie Curie-Paris6 University, UMR S679, Pitié-Salpêtrière Hospital</s1>
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</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
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</inist:fA14>
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<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
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<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
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</inist:fA14>
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<placeName><settlement type="city">Paris</settlement>
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</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
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</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
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<sZ>1 aut.</sZ>
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<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
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</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>AP-HP, Pitié-Salpêtrière Hospital, Centre d'Investigation Clinique</s1>
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<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>AP-HP, Pitié-Salpêtrière Hospital, Fédération des Maladies du Système Nerveux</s1>
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<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
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<s3>FRA</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, U679</s1>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pierre and Marie Curie-Paris6 University, UMR S679, Pitié-Salpêtrière Hospital</s1>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Federative Institute for Neuroscience Research (IFR70), Pitié-Salpêtrière Hospital</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>AP-HP, Pitié-Salpêtrière Hospital, Fédération des Maladies du Système Nerveux</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>AP-HP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Pierre and Marie Curie-Paris6 University, Pitié-Salpêtrière Medical School</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0247748</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 08-0247748 INIST</idno>
<idno type="RBID">Pascal:08-0247748</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001281</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001A38</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001360</idno>
<idno type="wicri:doubleKey">0885-3185:2008:Lohmann E:are:parkin:patients</idno>
<idno type="wicri:Area/Main/Merge">003968</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Are Parkin Patients Particularly Suited for Deep-Brain Stimulation?</title>
<author><name sortKey="Lohmann, Ebba" sort="Lohmann, Ebba" uniqKey="Lohmann E" first="Ebba" last="Lohmann">Ebba Lohmann</name>
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<sZ>1 aut.</sZ>
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<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
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<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
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<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
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<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
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<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name>
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<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
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<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
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<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
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<sZ>1 aut.</sZ>
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<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pierre and Marie Curie-Paris6 University, UMR S679, Pitié-Salpêtrière Hospital</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Federative Institute for Neuroscience Research (IFR70), Pitié-Salpêtrière Hospital</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Laine, Sophie" sort="Laine, Sophie" uniqKey="Laine S" first="Sophie" last="Laine">Sophie Laine</name>
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<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pierre and Marie Curie-Paris6 University, UMR S679, Pitié-Salpêtrière Hospital</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Federative Institute for Neuroscience Research (IFR70), Pitié-Salpêtrière Hospital</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tanguy, Marie Laure" sort="Tanguy, Marie Laure" uniqKey="Tanguy M" first="Marie-Laure" last="Tanguy">Marie-Laure Tanguy</name>
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<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
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<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>CHU Poitiers</wicri:noRegion>
<wicri:noRegion>Service de Neurologie, CHU Poitiers</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mesnage, Valerie" sort="Mesnage, Valerie" uniqKey="Mesnage V" first="Valérie" last="Mesnage">Valérie Mesnage</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>2AP-HP, Pitié-Salpêtrière Hospital, Service de Biostatistique</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
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<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName>
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<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>INSERM U318, Joseph Fourier University</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName>
</affiliation>
</author>
<author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name>
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<sZ>1 aut.</sZ>
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<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pierre and Marie Curie-Paris6 University, UMR S679, Pitié-Salpêtrière Hospital</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Federative Institute for Neuroscience Research (IFR70), Pitié-Salpêtrière Hospital</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>AP-HP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics</s1>
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<s3>FRA</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
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<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
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<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
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</placeName>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
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<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>AP-HP, Pitié-Salpêtrière Hospital, Centre d'Investigation Clinique</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
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<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
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<s3>FRA</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pierre and Marie Curie-Paris6 University, UMR S679, Pitié-Salpêtrière Hospital</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Federative Institute for Neuroscience Research (IFR70), Pitié-Salpêtrière Hospital</s1>
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<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>AP-HP, Pitié-Salpêtrière Hospital, Fédération des Maladies du Système Nerveux</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>AP-HP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Pierre and Marie Curie-Paris6 University, Pitié-Salpêtrière Medical School</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term>
<term>Human</term>
<term>Nervous system diseases</term>
<term>Parkin</term>
<term>Parkinson disease</term>
<term>Parkinsonism</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Parkinsonisme</term>
<term>Pathologie du système nerveux</term>
<term>Parkine</term>
<term>Homme</term>
<term>Stimulation cérébrale profonde</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Are parkin patients particularly suited for deep‐brain stimulation?</title>
<author><name sortKey="Lohmann, Ebba" sort="Lohmann, Ebba" uniqKey="Lohmann E" first="Ebba" last="Lohmann">Ebba Lohmann</name>
</author>
<author><name sortKey="Welter, Marie Aure" sort="Welter, Marie Aure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
</author>
<author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name>
</author>
<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
</author>
<author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
</author>
<author><name sortKey="Laine, Sophie" sort="Laine, Sophie" uniqKey="Laine S" first="Sophie" last="Laine">Sophie Laine</name>
</author>
<author><name sortKey="Tanguy, Marie Aure" sort="Tanguy, Marie Aure" uniqKey="Tanguy M" first="Marie-Laure" last="Tanguy">Marie-Laure Tanguy</name>
</author>
<author><name sortKey="Houeto, Jean Uc" sort="Houeto, Jean Uc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
</author>
<author><name sortKey="Mesnage, Valerie" sort="Mesnage, Valerie" uniqKey="Mesnage V" first="Valérie" last="Mesnage">Valérie Mesnage</name>
</author>
<author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
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<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName>
</affiliation>
</author>
<author><name sortKey="Alexandra Durr" sort="Alexandra Durr" uniqKey="Alexandra Durr" last="Alexandra Durr">Alexandra Durr</name>
</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
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<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Are parkin patients particularly suited for deep‐brain stimulation?</title>
<author><name sortKey="Lohmann, Ebba" sort="Lohmann, Ebba" uniqKey="Lohmann E" first="Ebba" last="Lohmann">Ebba Lohmann</name>
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<wicri:regionArea>INSERM, U679, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Welter, Marie Aure" sort="Welter, Marie Aure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
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<wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Centre d'Investigation Clinique, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Fédération des Maladies du Système Nerveux, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name>
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<wicri:regionArea>Département de Neurologie, CHU Grenoble, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Département de Neurologie, CHU Grenoble, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U679, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Laine, Sophie" sort="Laine, Sophie" uniqKey="Laine S" first="Sophie" last="Laine">Sophie Laine</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U679, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tanguy, Marie Aure" sort="Tanguy, Marie Aure" uniqKey="Tanguy M" first="Marie-Laure" last="Tanguy">Marie-Laure Tanguy</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>2AP‐HP, Pitié‐Salpêtrière Hospital, Service de Biostatistique, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
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</author>
<author><name sortKey="Houeto, Jean Uc" sort="Houeto, Jean Uc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
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<wicri:regionArea>Service de Neurologie, CHU Poitiers</wicri:regionArea>
<wicri:noRegion>CHU Poitiers</wicri:noRegion>
<wicri:noRegion>CHU Poitiers</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mesnage, Valerie" sort="Mesnage, Valerie" uniqKey="Mesnage V" first="Valérie" last="Mesnage">Valérie Mesnage</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>2AP‐HP, Pitié‐Salpêtrière Hospital, Service de Biostatistique, Paris</wicri:regionArea>
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<author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
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<wicri:regionArea>Département de Neurologie, CHU Grenoble, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
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<placeName><settlement type="city">Grenoble</settlement>
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<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U318, Joseph Fourier University, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
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<placeName><settlement type="city">Grenoble</settlement>
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<author><name sortKey="Alexandra Durr" sort="Alexandra Durr" uniqKey="Alexandra Durr" last="Alexandra Durr">Alexandra Durr</name>
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<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
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<affiliation wicri:level="1"><country xml:lang="fr">France</country>
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<placeName><settlement type="city">Paris</settlement>
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<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
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<wicri:regionArea>INSERM, U679, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
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<affiliation wicri:level="1"><country xml:lang="fr">France</country>
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</placeName>
<placeName><settlement type="city">Paris</settlement>
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</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea>
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<placeName><settlement type="city">Paris</settlement>
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</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Centre d'Investigation Clinique, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Fédération des Maladies du Système Nerveux, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
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<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
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<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
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<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U679, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
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<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Fédération des Maladies du Système Nerveux, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Pierre and Marie Curie‐Paris6 University, Pitié‐Salpêtrière Medical School, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
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<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
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<term>Aged</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>DNA Mutational Analysis</term>
<term>Deep Brain Stimulation</term>
<term>Dyskinesia, Drug-Induced</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genetic Testing</term>
<term>Heterozygote</term>
<term>Homozygote</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Parkinson disease</term>
<term>Parkinsonian Disorders (genetics)</term>
<term>Parkinsonian Disorders (therapy)</term>
<term>Treatment Outcome</term>
<term>Ubiquitin-Protein Ligases (genetics)</term>
<term>deep brain stimulation</term>
<term>early‐onset Parkinsonism</term>
<term>parkin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
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</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
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</keywords>
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</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>DNA Mutational Analysis</term>
<term>Deep Brain Stimulation</term>
<term>Dyskinesia, Drug-Induced</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Genetic Testing</term>
<term>Heterozygote</term>
<term>Homozygote</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Treatment Outcome</term>
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<front><div type="abstract" xml:lang="en">Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow‐up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results. © 2008 Movement Disorder Society</div>
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