MovDisordV3, Hal, Corpus, bibRecord, 000006

Are parkin patients particularly suited for deep-brain stimulation?

Identifieur interne : 000006 ( Hal/Corpus ); précédent : 000005; suivant : 000007

Are parkin patients particularly suited for deep-brain stimulation?

Auteurs : Ebba Lohmann ; Marie-Laure Welter ; Valérie Fraix ; Paul Krack ; Suzanne Lesage ; Sophie Laine ; Marie-Laure Tanguy ; Jean-Luc Houeto ; Valérie Mesnage ; Pierre Pollak ; Alexandra Durr ; Yves Agid ; Alexis Brice ; French Parkinson'S Disease Genetics Study Group

Source :

Movement Disorders [ 0885-3185 ] ; 2008-04-15.

RBID : Hal:inserm-00391529

Abstract

Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.

Url:

http://www.hal.inserm.fr/inserm-00391529

DOI: 10.1002/mds.21903

Links to Exploration step

Hal:inserm-00391529

Le document en format XML

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<author><name sortKey="Tanguy, Marie Laure" sort="Tanguy, Marie Laure" uniqKey="Tanguy M" first="Marie-Laure" last="Tanguy">Marie-Laure Tanguy</name>
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<author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
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<author><name sortKey="Mesnage, Valerie" sort="Mesnage, Valerie" uniqKey="Mesnage V" first="Valérie" last="Mesnage">Valérie Mesnage</name>
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<orgName type="acronym">UPMC</orgName>
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</address>
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<author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
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<author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name>
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<orgName type="acronym">UPMC</orgName>
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<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
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<orgName type="acronym">UPMC</orgName>
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<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
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<orgName type="acronym">UPMC</orgName>
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</author>
<author><name sortKey="Genetics Study Group, French Parkinson S Disease" sort="Genetics Study Group, French Parkinson S Disease" uniqKey="Genetics Study Group F" first="French Parkinson'S Disease" last="Genetics Study Group">French Parkinson'S Disease Genetics Study Group</name>
</author>
</analytic>
<idno type="DOI">10.1002/mds.21903</idno>
<series><title level="j">Movement Disorders</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date type="datePub">2008-04-15</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.</div>
</front>
</TEI>
<hal api="V3"><titleStmt><title xml:lang="en">Are parkin patients particularly suited for deep-brain stimulation?</title>
<author role="aut"><persName><forename type="first">Ebba</forename>
<surname>Lohmann</surname>
</persName>
<email></email>
<idno type="halauthor">233616</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Marie-Laure</forename>
<surname>Welter</surname>
</persName>
<email></email>
<idno type="halauthor">214475</idno>
<affiliation ref="#struct-2623"></affiliation>
<affiliation ref="#struct-43171"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Valérie</forename>
<surname>Fraix</surname>
</persName>
<email></email>
<idno type="halauthor">296411</idno>
<affiliation ref="#struct-14242"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Paul</forename>
<surname>Krack</surname>
</persName>
<email></email>
<idno type="halauthor">296412</idno>
<affiliation ref="#struct-14242"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Suzanne</forename>
<surname>Lesage</surname>
</persName>
<email></email>
<idno type="halauthor">233614</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Sophie</forename>
<surname>Laine</surname>
</persName>
<email></email>
<idno type="halauthor">410334</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Marie-Laure</forename>
<surname>Tanguy</surname>
</persName>
<email></email>
<idno type="halauthor">147259</idno>
<affiliation ref="#struct-15366"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Jean-Luc</forename>
<surname>Houeto</surname>
</persName>
<email></email>
<idno type="halauthor">214478</idno>
<affiliation ref="#struct-93187"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Valérie</forename>
<surname>Mesnage</surname>
</persName>
<email></email>
<idno type="halauthor">91213</idno>
<affiliation ref="#struct-15366"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Pierre</forename>
<surname>Pollak</surname>
</persName>
<email></email>
<idno type="halauthor">233619</idno>
<affiliation ref="#struct-14242"></affiliation>
<affiliation ref="#struct-2812"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Alexandra</forename>
<surname>Durr</surname>
</persName>
<email></email>
<idno type="halauthor">225857</idno>
<affiliation ref="#struct-3037"></affiliation>
<affiliation ref="#struct-16845"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Yves</forename>
<surname>Agid</surname>
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<author role="aut"><persName><forename type="first">French Parkinson'S Disease</forename>
<surname>Genetics Study Group</surname>
</persName>
<email></email>
<idno type="halauthor">410335</idno>
</author>
<editor role="depositor"><persName><forename>Marc</forename>
<surname>Savasta</surname>
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<email>marc.savasta@ujf-grenoble.fr</email>
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<date type="whenModified">2009-06-12 16:09:18</date>
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<idno type="halRef">Movement Disorders, Wiley, 2008, 23 (5), pp.740-3. <10.1002/mds.21903></idno>
</publicationStmt>
<seriesStmt><idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
<idno type="stamp" n="UNIV-PARIS6">Université Pierre et Marie Curie - Paris VI</idno>
<idno type="stamp" n="UNIV-GRENOBLE1" p="UGA">Université Joseph Fourier - Grenoble I</idno>
<idno type="stamp" n="APHP" p="INSERM">AP-HP</idno>
<idno type="stamp" n="UPMC">Université Pierre et Marie Curie</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Are parkin patients particularly suited for deep-brain stimulation?</title>
<author role="aut"><persName><forename type="first">Ebba</forename>
<surname>Lohmann</surname>
</persName>
<idno type="halAuthorId">233616</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Marie-Laure</forename>
<surname>Welter</surname>
</persName>
<idno type="halAuthorId">214475</idno>
<affiliation ref="#struct-2623"></affiliation>
<affiliation ref="#struct-43171"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Valérie</forename>
<surname>Fraix</surname>
</persName>
<idno type="halAuthorId">296411</idno>
<affiliation ref="#struct-14242"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Paul</forename>
<surname>Krack</surname>
</persName>
<idno type="halAuthorId">296412</idno>
<affiliation ref="#struct-14242"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Suzanne</forename>
<surname>Lesage</surname>
</persName>
<idno type="halAuthorId">233614</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Sophie</forename>
<surname>Laine</surname>
</persName>
<idno type="halAuthorId">410334</idno>
<affiliation ref="#struct-3037"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Marie-Laure</forename>
<surname>Tanguy</surname>
</persName>
<idno type="halAuthorId">147259</idno>
<affiliation ref="#struct-15366"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Jean-Luc</forename>
<surname>Houeto</surname>
</persName>
<idno type="halAuthorId">214478</idno>
<affiliation ref="#struct-93187"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Valérie</forename>
<surname>Mesnage</surname>
</persName>
<idno type="halAuthorId">91213</idno>
<affiliation ref="#struct-15366"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Pierre</forename>
<surname>Pollak</surname>
</persName>
<idno type="halAuthorId">233619</idno>
<affiliation ref="#struct-14242"></affiliation>
<affiliation ref="#struct-2812"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Alexandra</forename>
<surname>Durr</surname>
</persName>
<idno type="halAuthorId">225857</idno>
<affiliation ref="#struct-3037"></affiliation>
<affiliation ref="#struct-16845"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Yves</forename>
<surname>Agid</surname>
</persName>
<idno type="halAuthorId">217013</idno>
<affiliation ref="#struct-3037"></affiliation>
<affiliation ref="#struct-2623"></affiliation>
<affiliation ref="#struct-16845"></affiliation>
</author>
<author role="aut"><persName><forename type="first">Alexis</forename>
<surname>Brice</surname>
</persName>
<idno type="halAuthorId">183596</idno>
<affiliation ref="#struct-3037"></affiliation>
<affiliation ref="#struct-43171"></affiliation>
<affiliation ref="#struct-16845"></affiliation>
</author>
<author role="aut"><persName><forename type="first">French Parkinson'S Disease</forename>
<surname>Genetics Study Group</surname>
</persName>
<idno type="halAuthorId">410335</idno>
</author>
</analytic>
<monogr><idno type="halJournalId" status="VALID">17211</idno>
<idno type="issn">0885-3185</idno>
<idno type="eissn">1531-8257</idno>
<title level="j">Movement Disorders</title>
<imprint><publisher>Wiley</publisher>
<biblScope unit="volume">23</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="pp">740-3</biblScope>
<date type="datePub">2008-04-15</date>
</imprint>
</monogr>
<idno type="doi">10.1002/mds.21903</idno>
<idno type="pubmed">18228569</idno>
</biblStruct>
</sourceDesc>
<profileDesc><langUsage><language ident="en">English</language>
</langUsage>
<textClass><classCode scheme="mesh">Adult</classCode>
<classCode scheme="mesh">Aged</classCode>
<classCode scheme="mesh">Homozygote</classCode>
<classCode scheme="mesh">Humans</classCode>
<classCode scheme="mesh">Levodopa</classCode>
<classCode scheme="mesh">Male</classCode>
<classCode scheme="mesh">Middle Aged</classCode>
<classCode scheme="mesh">Mutation</classCode>
<classCode scheme="mesh">Parkinsonian Disorders</classCode>
<classCode scheme="mesh">Treatment Outcome</classCode>
<classCode scheme="mesh">Ubiquitin-Protein Ligases</classCode>
<classCode scheme="mesh">Antiparkinson Agents</classCode>
<classCode scheme="mesh">DNA Mutational Analysis</classCode>
<classCode scheme="mesh">Deep Brain Stimulation</classCode>
<classCode scheme="mesh">Dyskinesia, Drug-Induced</classCode>
<classCode scheme="mesh">Female</classCode>
<classCode scheme="mesh">Follow-Up Studies</classCode>
<classCode scheme="mesh">Genetic Screening</classCode>
<classCode scheme="mesh">Heterozygote</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en">Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.</abstract>
<particDesc><org type="consortium">Collaboration</org>
</particDesc>
</profileDesc>
</hal>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Are parkin patients particularly suited for deep-brain stimulation?

Are parkin patients particularly suited for deep-brain stimulation?

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