MovDisordV3, PascalFrancis, Corpus, bibRecord, 001281

Are Parkin Patients Particularly Suited for Deep-Brain Stimulation?

Identifieur interne : 001281 ( PascalFrancis/Corpus ); précédent : 001280; suivant : 001282

Are Parkin Patients Particularly Suited for Deep-Brain Stimulation?

Auteurs : Ebba Lohmann ; Marie-Laure Welter ; Valérie Fraix ; Paul Krack ; Suzanne Lesage ; Sophie Laine ; Marie-Laure Tanguy ; Jean-Luc Houeto ; Valérie Mesnage ; Pierre Pollak ; Alexandra Durr ; Yves Agid ; Alexis Brice

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0247748

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Parkinsonisme, Pathologie du système nerveux, Parkine, Homme, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Deep brain stimulation, Human, Nervous system diseases, Parkin, Parkinson disease, Parkinsonism.

Abstract

Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A14	`03`			`@1 Federative Institute for Neuroscience Research (IFR70), Pitié-Salpêtrière Hospital @2 Paris @3 FRA @Z 1 aut. @Z 5 aut. @Z 6 aut. @Z 11 aut. @Z 12 aut. @Z 13 aut.`
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A17	`01`	`1`		`@1 French Parkinson's Disease Genetics study group @3 FRA`
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C01	`01`		`ENG`	@0 Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.
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C03	`01`	`X`	`FRE`	`@0 Maladie de Parkinson @2 NM @5 01`
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C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Parkinsonisme @2 NM @5 02`
C03	`02`	`X`	`ENG`	`@0 Parkinsonism @2 NM @5 02`
C03	`02`	`X`	`SPA`	`@0 Parkinson síndrome @2 NM @5 02`
C03	`03`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 03`
C03	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 03`
C03	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Parkine @5 09`
C03	`04`	`X`	`ENG`	`@0 Parkin @5 09`
C03	`04`	`X`	`SPA`	`@0 Parkin @5 09`
C03	`05`	`X`	`FRE`	`@0 Homme @5 10`
C03	`05`	`X`	`ENG`	`@0 Human @5 10`
C03	`05`	`X`	`SPA`	`@0 Hombre @5 10`
C03	`06`	`X`	`FRE`	`@0 Stimulation cérébrale profonde @4 CD @5 96`
C03	`06`	`X`	`ENG`	`@0 Deep brain stimulation @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
C07	`04`	`X`	`ENG`	`@0 Central nervous system disease @5 40`
C07	`04`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 40`
N21				`@1 162`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 08-0247748 INIST
ET :	Are Parkin Patients Particularly Suited for Deep-Brain Stimulation?
AU :	LOHMANN (Ebba); WELTER (Marie-Laure); FRAIX (Valérie); KRACK (Paul); LESAGE (Suzanne); LAINE (Sophie); TANGUY (Marie-Laure); HOUETO (Jean-Luc); MESNAGE (Valérie); POLLAK (Pierre); DURR (Alexandra); AGID (Yves); BRICE (Alexis)
AF :	INSERM, U679/Paris/France (1 aut., 5 aut., 6 aut., 11 aut., 12 aut., 13 aut.); Pierre and Marie Curie-Paris6 University, UMR S679, Pitié-Salpêtrière Hospital/Paris/France (1 aut., 5 aut., 6 aut., 11 aut., 12 aut., 13 aut.); Federative Institute for Neuroscience Research (IFR70), Pitié-Salpêtrière Hospital/Paris/France (1 aut., 5 aut., 6 aut., 11 aut., 12 aut., 13 aut.); AP-HP, Pitié-Salpêtrière Hospital, Centre d'Investigation Clinique/Paris/France (2 aut., 12 aut.); AP-HP, Pitié-Salpêtrière Hospital, Fédération des Maladies du Système Nerveux/Paris/France (2 aut., 12 aut., 13 aut.); Département de Neurologie, CHU Grenoble/Grenoble/France (3 aut., 4 aut., 10 aut.); 2AP-HP, Pitié-Salpêtrière Hospital, Service de Biostatistique/Paris/France (7 aut., 9 aut.); Service de Neurologie, CHU Poitiers/France (8 aut.); INSERM U318, Joseph Fourier University/Grenoble/France (10 aut.); AP-HP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics/Paris/France (11 aut., 12 aut., 13 aut.); Pierre and Marie Curie-Paris6 University, Pitié-Salpêtrière Medical School/Paris/France (13 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 5; Pp. 740-743; Bibl. 15 ref.
LA :	Anglais
EA :	Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.
CC :	002B17; 002B17F
FD :	Maladie de Parkinson; Parkinsonisme; Pathologie du système nerveux; Parkine; Homme; Stimulation cérébrale profonde
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Parkinson disease; Parkinsonism; Nervous system diseases; Parkin; Human; Deep brain stimulation
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Parkinson enfermedad; Parkinson síndrome; Sistema nervioso patología; Parkin; Hombre
LO :	INIST-20953.354000173776990170
ID :	08-0247748

Links to Exploration step

Pascal:08-0247748

Le document en format XML

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<author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name>
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<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
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</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0247748</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 08-0247748 INIST</idno>
<idno type="RBID">Pascal:08-0247748</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001281</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Are Parkin Patients Particularly Suited for Deep-Brain Stimulation?</title>
<author><name sortKey="Lohmann, Ebba" sort="Lohmann, Ebba" uniqKey="Lohmann E" first="Ebba" last="Lohmann">Ebba Lohmann</name>
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</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Pierre and Marie Curie-Paris6 University, UMR S679, Pitié-Salpêtrière Hospital</s1>
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</author>
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</author>
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<author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
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<author><name sortKey="Tanguy, Marie Laure" sort="Tanguy, Marie Laure" uniqKey="Tanguy M" first="Marie-Laure" last="Tanguy">Marie-Laure Tanguy</name>
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<author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
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<sZ>8 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Mesnage, Valerie" sort="Mesnage, Valerie" uniqKey="Mesnage V" first="Valérie" last="Mesnage">Valérie Mesnage</name>
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<author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
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<affiliation><inist:fA14 i1="09"><s1>INSERM U318, Joseph Fourier University</s1>
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<sZ>10 aut.</sZ>
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</affiliation>
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<author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name>
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</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
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<s2>Paris</s2>
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<sZ>1 aut.</sZ>
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</affiliation>
<affiliation><inist:fA14 i1="04"><s1>AP-HP, Pitié-Salpêtrière Hospital, Centre d'Investigation Clinique</s1>
<s2>Paris</s2>
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<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
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</affiliation>
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<sZ>2 aut.</sZ>
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</affiliation>
<affiliation><inist:fA14 i1="10"><s1>AP-HP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics</s1>
<s2>Paris</s2>
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<sZ>11 aut.</sZ>
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</author>
<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
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<affiliation><inist:fA14 i1="02"><s1>Pierre and Marie Curie-Paris6 University, UMR S679, Pitié-Salpêtrière Hospital</s1>
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</affiliation>
<affiliation><inist:fA14 i1="05"><s1>AP-HP, Pitié-Salpêtrière Hospital, Fédération des Maladies du Système Nerveux</s1>
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</affiliation>
<affiliation><inist:fA14 i1="10"><s1>AP-HP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="11"><s1>Pierre and Marie Curie-Paris6 University, Pitié-Salpêtrière Medical School</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term>
<term>Human</term>
<term>Nervous system diseases</term>
<term>Parkin</term>
<term>Parkinson disease</term>
<term>Parkinsonism</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Parkinsonisme</term>
<term>Pathologie du   système nerveux</term>
<term>Parkine</term>
<term>Homme</term>
<term>Stimulation cérébrale profonde</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0>
</fA01>
<fA03 i2="1"><s0>Mov. disord.</s0>
</fA03>
<fA05><s2>23</s2>
</fA05>
<fA06><s2>5</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Are Parkin Patients Particularly Suited for Deep-Brain Stimulation?</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>LOHMANN (Ebba)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>WELTER (Marie-Laure)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>FRAIX (Valérie)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>KRACK (Paul)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>LESAGE (Suzanne)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>LAINE (Sophie)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>TANGUY (Marie-Laure)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>HOUETO (Jean-Luc)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>MESNAGE (Valérie)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>POLLAK (Pierre)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>DURR (Alexandra)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>AGID (Yves)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>BRICE (Alexis)</s1>
</fA11>
<fA14 i1="01"><s1>INSERM, U679</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Pierre and Marie Curie-Paris6 University, UMR S679, Pitié-Salpêtrière Hospital</s1>
<s2>Paris</s2>
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<sZ>6 aut.</sZ>
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<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Federative Institute for Neuroscience Research (IFR70), Pitié-Salpêtrière Hospital</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
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<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>AP-HP, Pitié-Salpêtrière Hospital, Centre d'Investigation Clinique</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>AP-HP, Pitié-Salpêtrière Hospital, Fédération des Maladies du Système Nerveux</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
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<fA14 i1="06"><s1>Département de Neurologie, CHU Grenoble</s1>
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<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>2AP-HP, Pitié-Salpêtrière Hospital, Service de Biostatistique</s1>
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<sZ>9 aut.</sZ>
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<fA14 i1="08"><s1>Service de Neurologie, CHU Poitiers</s1>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
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<fA14 i1="09"><s1>INSERM U318, Joseph Fourier University</s1>
<s2>Grenoble</s2>
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<sZ>10 aut.</sZ>
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<fA14 i1="10"><s1>AP-HP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics</s1>
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<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
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<fA14 i1="11"><s1>Pierre and Marie Curie-Paris6 University, Pitié-Salpêtrière Medical School</s1>
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<sZ>13 aut.</sZ>
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<fA17 i1="01" i2="1"><s1>French Parkinson's Disease Genetics study group</s1>
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<fC01 i1="01" l="ENG"><s0>Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.</s0>
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<s5>37</s5>
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<s5>38</s5>
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<s5>39</s5>
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<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
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<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>40</s5>
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<ET>Are Parkin Patients Particularly Suited for Deep-Brain Stimulation?</ET>
<AU>LOHMANN (Ebba); WELTER (Marie-Laure); FRAIX (Valérie); KRACK (Paul); LESAGE (Suzanne); LAINE (Sophie); TANGUY (Marie-Laure); HOUETO (Jean-Luc); MESNAGE (Valérie); POLLAK (Pierre); DURR (Alexandra); AGID (Yves); BRICE (Alexis)</AU>
<AF>INSERM, U679/Paris/France (1 aut., 5 aut., 6 aut., 11 aut., 12 aut., 13 aut.); Pierre and Marie Curie-Paris6 University, UMR S679, Pitié-Salpêtrière Hospital/Paris/France (1 aut., 5 aut., 6 aut., 11 aut., 12 aut., 13 aut.); Federative Institute for Neuroscience Research (IFR70), Pitié-Salpêtrière Hospital/Paris/France (1 aut., 5 aut., 6 aut., 11 aut., 12 aut., 13 aut.); AP-HP, Pitié-Salpêtrière Hospital, Centre d'Investigation Clinique/Paris/France (2 aut., 12 aut.); AP-HP, Pitié-Salpêtrière Hospital, Fédération des Maladies du Système Nerveux/Paris/France (2 aut., 12 aut., 13 aut.); Département de Neurologie, CHU Grenoble/Grenoble/France (3 aut., 4 aut., 10 aut.); 2AP-HP, Pitié-Salpêtrière Hospital, Service de Biostatistique/Paris/France (7 aut., 9 aut.); Service de Neurologie, CHU Poitiers/France (8 aut.); INSERM U318, Joseph Fourier University/Grenoble/France (10 aut.); AP-HP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics/Paris/France (11 aut., 12 aut., 13 aut.); Pierre and Marie Curie-Paris6 University, Pitié-Salpêtrière Medical School/Paris/France (13 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 5; Pp. 740-743; Bibl. 15 ref.</SO>
<LA>Anglais</LA>
<EA>Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.</EA>
<CC>002B17; 002B17F</CC>
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<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
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<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Parkinson síndrome; Sistema nervioso patología; Parkin; Hombre</SD>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Are Parkin Patients Particularly Suited for Deep-Brain Stimulation?

Are Parkin Patients Particularly Suited for Deep-Brain Stimulation?

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