Are parkin patients particularly suited for deep‐brain stimulation?
Identifieur interne : 003132 ( Istex/Curation ); précédent : 003131; suivant : 003133Are parkin patients particularly suited for deep‐brain stimulation?
Auteurs : Ebba Lohmann [France] ; Marie-Laure Welter [France] ; Valérie Fraix [France] ; Paul Krack [France] ; Suzanne Lesage [France] ; Sophie Laine [France] ; Marie-Laure Tanguy [France] ; Jean-Luc Houeto [France] ; Valérie Mesnage [France] ; Pierre Pollak [France] ; Alexandra Durr [France] ; Yves Agid [France] ; Alexis Brice [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-04-15.
English descriptors
Abstract
Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow‐up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.21903
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<affiliation wicri:level="1"><mods:affiliation>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
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<affiliation wicri:level="1"><mods:affiliation>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation>
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<affiliation wicri:level="1"><mods:affiliation>AP‐HP, Pitié‐Salpêtrière Hospital, Centre d'Investigation Clinique, Paris, France</mods:affiliation>
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<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
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<affiliation wicri:level="1"><mods:affiliation>Pierre and Marie Curie‐Paris6 University, Pitié‐Salpêtrière Medical School, Paris, France</mods:affiliation>
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<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2008-04-15">2008-04-15</date>
<biblScope unit="vol">23</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="740">740</biblScope>
<biblScope unit="page" to="743">743</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">4459CC74F45A00448CC0C08EE9BB433983021C4F</idno>
<idno type="DOI">10.1002/mds.21903</idno>
<idno type="ArticleID">MDS21903</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson disease</term>
<term>deep brain stimulation</term>
<term>early‐onset Parkinsonism</term>
<term>parkin</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow‐up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results. © 2008 Movement Disorder Society</div>
</front>
</TEI>
</record>
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