Are parkin patients particularly suited for deep‐brain stimulation?
Identifieur interne : 003132 ( Istex/Curation ); précédent : 003131; suivant : 003133Are parkin patients particularly suited for deep‐brain stimulation?
Auteurs : Ebba Lohmann [France] ; Marie-Laure Welter [France] ; Valérie Fraix [France] ; Paul Krack [France] ; Suzanne Lesage [France] ; Sophie Laine [France] ; Marie-Laure Tanguy [France] ; Jean-Luc Houeto [France] ; Valérie Mesnage [France] ; Pierre Pollak [France] ; Alexandra Durr [France] ; Yves Agid [France] ; Alexis Brice [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-04-15.
English descriptors
Abstract
Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow‐up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.21903
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France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U679, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Welter, Marie Aure" sort="Welter, Marie Aure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Pitié‐Salpêtrière Hospital, Centre d'Investigation Clinique, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Centre d'Investigation Clinique, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Pitié‐Salpêtrière Hospital, Fédération des Maladies du Système Nerveux, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Fédération des Maladies du Système Nerveux, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><affiliation wicri:level="1"><mods:affiliation>Département de Neurologie, CHU Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Neurologie, CHU Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation wicri:level="1"><mods:affiliation>Département de Neurologie, CHU Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Neurologie, CHU Grenoble, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation wicri:level="1"><mods:affiliation>INSERM, U679, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U679, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Laine, Sophie" sort="Laine, Sophie" uniqKey="Laine S" first="Sophie" last="Laine">Sophie Laine</name><affiliation wicri:level="1"><mods:affiliation>INSERM, U679, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U679, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Tanguy, Marie Aure" sort="Tanguy, Marie Aure" uniqKey="Tanguy M" first="Marie-Laure" last="Tanguy">Marie-Laure Tanguy</name><affiliation wicri:level="1"><mods:affiliation>2AP‐HP, Pitié‐Salpêtrière Hospital, Service de Biostatistique, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>2AP‐HP, Pitié‐Salpêtrière Hospital, Service de Biostatistique, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Houeto, Jean Uc" sort="Houeto, Jean Uc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name><affiliation wicri:level="1"><mods:affiliation>Service de Neurologie, CHU Poitiers, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU Poitiers</wicri:regionArea></affiliation></author><author><name sortKey="Mesnage, Valerie" sort="Mesnage, Valerie" uniqKey="Mesnage V" first="Valérie" last="Mesnage">Valérie Mesnage</name><affiliation wicri:level="1"><mods:affiliation>2AP‐HP, Pitié‐Salpêtrière Hospital, Service de Biostatistique, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>2AP‐HP, Pitié‐Salpêtrière Hospital, Service de Biostatistique, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation wicri:level="1"><mods:affiliation>Département de Neurologie, CHU Grenoble, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de Neurologie, CHU Grenoble, Grenoble</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>INSERM U318, Joseph Fourier University, Grenoble, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U318, Joseph Fourier University, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Alexandra Durr" sort="Alexandra Durr" uniqKey="Alexandra Durr" last="Alexandra Durr">Alexandra Durr</name><affiliation wicri:level="1"><mods:affiliation>INSERM, U679, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U679, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Pitié‐Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name><affiliation wicri:level="1"><mods:affiliation>INSERM, U679, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U679, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Pitié‐Salpêtrière Hospital, Centre d'Investigation Clinique, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Centre d'Investigation Clinique, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Pitié‐Salpêtrière Hospital, Fédération des Maladies du Système Nerveux, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Fédération des Maladies du Système Nerveux, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Pitié‐Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="1"><mods:affiliation>INSERM, U679, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U679, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pierre and Marie Curie‐Paris6 University, UMR S679, Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Federative Institute for Neuroscience Research (IFR70), Pitié‐Salpêtrière Hospital, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Pitié‐Salpêtrière Hospital, Fédération des Maladies du Système Nerveux, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Fédération des Maladies du Système Nerveux, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>AP‐HP, Pitié‐Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Pitié‐Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Pierre and Marie Curie‐Paris6 University, Pitié‐Salpêtrière Medical School, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pierre and Marie Curie‐Paris6 University, Pitié‐Salpêtrière Medical School, Paris</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-04-15">2008-04-15</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="740">740</biblScope><biblScope unit="page" to="743">743</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">4459CC74F45A00448CC0C08EE9BB433983021C4F</idno><idno type="DOI">10.1002/mds.21903</idno><idno type="ArticleID">MDS21903</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson disease</term><term>deep brain stimulation</term><term>early‐onset Parkinsonism</term><term>parkin</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow‐up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results. © 2008 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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