Are parkin patients particularly suited for deep-brain stimulation?
Identifieur interne : 000038 ( Hal/Checkpoint ); précédent : 000037; suivant : 000039Are parkin patients particularly suited for deep-brain stimulation?
Auteurs : Ebba Lohmann [France] ; Marie-Laure Welter [France] ; Valérie Fraix [France] ; Paul Krack [France] ; Suzanne Lesage [France] ; Sophie Laine [France] ; Marie-Laure Tanguy [France] ; Jean-Luc Houeto [France] ; Valérie Mesnage [France] ; Pierre Pollak [France] ; Alexandra Durr [France] ; Yves Agid [France] ; Alexis Brice [France] ; French Parkinson'S Disease Genetics Study GroupSource :
- Movement Disorders [ 0885-3185 ] ; 2008-04-15.
Abstract
Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.
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DOI: 10.1002/mds.21903
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Are parkin patients particularly suited for deep-brain stimulation?</title>
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<idno type="DOI">10.1002/mds.21903</idno>
<series><title level="j">Movement Disorders</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date type="datePub">2008-04-15</date>
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<front><div type="abstract" xml:lang="en">Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.</div>
</front>
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<hal api="V3"><titleStmt><title xml:lang="en">Are parkin patients particularly suited for deep-brain stimulation?</title>
<author role="aut"><persName><forename type="first">Ebba</forename>
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<author role="aut"><persName><forename type="first">Marie-Laure</forename>
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<author role="aut"><persName><forename type="first">Valérie</forename>
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<author role="aut"><persName><forename type="first">Paul</forename>
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<author role="aut"><persName><forename type="first">Suzanne</forename>
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<author role="aut"><persName><forename type="first">Sophie</forename>
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<author role="aut"><persName><forename type="first">Marie-Laure</forename>
<surname>Tanguy</surname>
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<author role="aut"><persName><forename type="first">Jean-Luc</forename>
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<author role="aut"><persName><forename type="first">Pierre</forename>
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<author role="aut"><persName><forename type="first">Alexandra</forename>
<surname>Durr</surname>
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<author role="aut"><persName><forename type="first">Yves</forename>
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<date type="whenModified">2009-06-12 16:09:18</date>
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<imprint><publisher>Wiley</publisher>
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<biblScope unit="issue">5</biblScope>
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<profileDesc><langUsage><language ident="en">English</language>
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<textClass><classCode scheme="mesh">Adult</classCode>
<classCode scheme="mesh">Aged</classCode>
<classCode scheme="mesh">Homozygote</classCode>
<classCode scheme="mesh">Humans</classCode>
<classCode scheme="mesh">Levodopa</classCode>
<classCode scheme="mesh">Male</classCode>
<classCode scheme="mesh">Middle Aged</classCode>
<classCode scheme="mesh">Mutation</classCode>
<classCode scheme="mesh">Parkinsonian Disorders</classCode>
<classCode scheme="mesh">Treatment Outcome</classCode>
<classCode scheme="mesh">Ubiquitin-Protein Ligases</classCode>
<classCode scheme="mesh">Antiparkinson Agents</classCode>
<classCode scheme="mesh">DNA Mutational Analysis</classCode>
<classCode scheme="mesh">Deep Brain Stimulation</classCode>
<classCode scheme="mesh">Dyskinesia, Drug-Induced</classCode>
<classCode scheme="mesh">Female</classCode>
<classCode scheme="mesh">Follow-Up Studies</classCode>
<classCode scheme="mesh">Genetic Screening</classCode>
<classCode scheme="mesh">Heterozygote</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
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<abstract xml:lang="en">Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.</abstract>
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