Excessive dopamine neuron loss in progressive supranuclear palsy
Identifieur interne : 002853 ( Main/Curation ); précédent : 002852; suivant : 002854Excessive dopamine neuron loss in progressive supranuclear palsy
Auteurs : Karen E. Murphy [Australie] ; Tanya Karaconji [Australie] ; Craig D. Hardman [Australie] ; Glenda M. Halliday [Australie]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-03-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Cell death, Disease Progression, Dopamine, Dopamine (deficiency), Dopamine (metabolism), Dopamine Agonists (therapeutic use), Female, Humans, Levodopa (therapeutic use), Male, Midbrain, Nerve Degeneration (metabolism), Nervous system diseases, Neuron, Neurons (metabolism), Neurons (pathology), Parkinson disease, Parkinson's disease, Substantia Nigra (metabolism), Substantia Nigra (pathology), Supranuclear Palsy, Progressive (drug therapy), Supranuclear Palsy, Progressive (metabolism), Supranuclear Palsy, Progressive (pathology), dopamine neurons, midbrain, neurodegeneration, progressive supranuclear palsy.
- MESH :
- chemical , deficiency : Dopamine.
- chemical , metabolism : Dopamine.
- chemical , therapeutic use : Dopamine Agonists, Levodopa.
- drug therapy : Supranuclear Palsy, Progressive.
- metabolism : Nerve Degeneration, Neurons, Substantia Nigra, Supranuclear Palsy, Progressive.
- pathology : Neurons, Substantia Nigra, Supranuclear Palsy, Progressive.
- Aged, Disease Progression, Female, Humans, Male.
Abstract
Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra. We observed more widespread dopamine neuron loss in the extranigral A10 midbrain cell groups in PSP compared with PD. These cell groups innervate subcortical and cortical regions and may be required for adequate response to levodopa therapy. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21907
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<idno type="DOI">10.1002/mds.21907</idno>
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<term>Disease Progression</term>
<term>Dopamine (deficiency)</term>
<term>Dopamine (metabolism)</term>
<term>Dopamine Agonists (therapeutic use)</term>
<term>Female</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
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<term>Nerve Degeneration (metabolism)</term>
<term>Neurons (metabolism)</term>
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<term>Substantia Nigra (metabolism)</term>
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<term>Supranuclear Palsy, Progressive (metabolism)</term>
<term>Supranuclear Palsy, Progressive (pathology)</term>
<term>dopamine neurons</term>
<term>midbrain</term>
<term>neurodegeneration</term>
<term>progressive supranuclear palsy</term>
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<term>Levodopa</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Nerve Degeneration</term>
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<term>Supranuclear Palsy, Progressive</term>
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<term>Supranuclear Palsy, Progressive</term>
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<front><div type="abstract" xml:lang="en">Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra. We observed more widespread dopamine neuron loss in the extranigral A10 midbrain cell groups in PSP compared with PD. These cell groups innervate subcortical and cortical regions and may be required for adequate response to levodopa therapy. © 2007 Movement Disorder Society</div>
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