Excessive dopamine neuron loss in progressive supranuclear palsy.
Identifieur interne : 001F91 ( Ncbi/Checkpoint ); précédent : 001F90; suivant : 001F92Excessive dopamine neuron loss in progressive supranuclear palsy.
Auteurs : Karen E. Murphy [Australie] ; Tanya Karaconji ; Craig D. Hardman ; Glenda M. HallidaySource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Disease Progression, Dopamine (deficiency), Dopamine (metabolism), Dopamine Agonists (therapeutic use), Female, Humans, Levodopa (therapeutic use), Male, Nerve Degeneration (metabolism), Neurons (metabolism), Neurons (pathology), Substantia Nigra (metabolism), Substantia Nigra (pathology), Supranuclear Palsy, Progressive (drug therapy), Supranuclear Palsy, Progressive (metabolism), Supranuclear Palsy, Progressive (pathology).
- MESH :
- chemical , deficiency : Dopamine.
- chemical , metabolism : Dopamine.
- chemical , therapeutic use : Dopamine Agonists, Levodopa.
- drug therapy : Supranuclear Palsy, Progressive.
- metabolism : Nerve Degeneration, Neurons, Substantia Nigra, Supranuclear Palsy, Progressive.
- pathology : Neurons, Substantia Nigra, Supranuclear Palsy, Progressive.
- Aged, Disease Progression, Female, Humans, Male.
Abstract
Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra. We observed more widespread dopamine neuron loss in the extranigral A10 midbrain cell groups in PSP compared with PD. These cell groups innervate subcortical and cortical regions and may be required for adequate response to levodopa therapy.
DOI: 10.1002/mds.21907
PubMed: 18163454
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Excessive dopamine neuron loss in progressive supranuclear palsy.</title><author><name sortKey="Murphy, Karen E" sort="Murphy, Karen E" uniqKey="Murphy K" first="Karen E" last="Murphy">Karen E. Murphy</name><affiliation wicri:level="1"><nlm:affiliation>Prince of Wales Medical Research Institute, Randwick, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Prince of Wales Medical Research Institute, Randwick</wicri:regionArea><wicri:noRegion>Randwick</wicri:noRegion></affiliation></author><author><name sortKey="Karaconji, Tanya" sort="Karaconji, Tanya" uniqKey="Karaconji T" first="Tanya" last="Karaconji">Tanya Karaconji</name></author><author><name sortKey="Hardman, Craig D" sort="Hardman, Craig D" uniqKey="Hardman C" first="Craig D" last="Hardman">Craig D. Hardman</name></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M" last="Halliday">Glenda M. Halliday</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.21907</idno><idno type="RBID">pubmed:18163454</idno><idno type="pmid">18163454</idno><idno type="wicri:Area/PubMed/Corpus">002368</idno><idno type="wicri:Area/PubMed/Curation">002368</idno><idno type="wicri:Area/PubMed/Checkpoint">002303</idno><idno type="wicri:Area/Ncbi/Merge">001F91</idno><idno type="wicri:Area/Ncbi/Curation">001F91</idno><idno type="wicri:Area/Ncbi/Checkpoint">001F91</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Excessive dopamine neuron loss in progressive supranuclear palsy.</title><author><name sortKey="Murphy, Karen E" sort="Murphy, Karen E" uniqKey="Murphy K" first="Karen E" last="Murphy">Karen E. Murphy</name><affiliation wicri:level="1"><nlm:affiliation>Prince of Wales Medical Research Institute, Randwick, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Prince of Wales Medical Research Institute, Randwick</wicri:regionArea><wicri:noRegion>Randwick</wicri:noRegion></affiliation></author><author><name sortKey="Karaconji, Tanya" sort="Karaconji, Tanya" uniqKey="Karaconji T" first="Tanya" last="Karaconji">Tanya Karaconji</name></author><author><name sortKey="Hardman, Craig D" sort="Hardman, Craig D" uniqKey="Hardman C" first="Craig D" last="Hardman">Craig D. Hardman</name></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M" last="Halliday">Glenda M. Halliday</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Disease Progression</term><term>Dopamine (deficiency)</term><term>Dopamine (metabolism)</term><term>Dopamine Agonists (therapeutic use)</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Nerve Degeneration (metabolism)</term><term>Neurons (metabolism)</term><term>Neurons (pathology)</term><term>Substantia Nigra (metabolism)</term><term>Substantia Nigra (pathology)</term><term>Supranuclear Palsy, Progressive (drug therapy)</term><term>Supranuclear Palsy, Progressive (metabolism)</term><term>Supranuclear Palsy, Progressive (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Nerve Degeneration</term><term>Neurons</term><term>Substantia Nigra</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neurons</term><term>Substantia Nigra</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra. We observed more widespread dopamine neuron loss in the extranigral A10 midbrain cell groups in PSP compared with PD. These cell groups innervate subcortical and cortical regions and may be required for adequate response to levodopa therapy.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M" last="Halliday">Glenda M. Halliday</name><name sortKey="Hardman, Craig D" sort="Hardman, Craig D" uniqKey="Hardman C" first="Craig D" last="Hardman">Craig D. Hardman</name><name sortKey="Karaconji, Tanya" sort="Karaconji, Tanya" uniqKey="Karaconji T" first="Tanya" last="Karaconji">Tanya Karaconji</name></noCountry><country name="Australie"><noRegion><name sortKey="Murphy, Karen E" sort="Murphy, Karen E" uniqKey="Murphy K" first="Karen E" last="Murphy">Karen E. 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