Excessive Dopamine Neuron Loss in Progressive Supranuclear Palsy
Identifieur interne : 003867 ( Main/Merge ); précédent : 003866; suivant : 003868Excessive Dopamine Neuron Loss in Progressive Supranuclear Palsy
Auteurs : Karen E. Murphy [Australie] ; Tanya Karaconji [Australie] ; Craig D. Hardman [Australie] ; Glenda M. Halliday [Australie]Source :
- Movement disorders [ 0885-3185 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra. We observed more widespread dopamine neuron loss in the extranigral A10 midbrain cell groups in PSP compared with PD. These cell groups innervate subcortical and cortical regions and may be required for adequate response to levodopa therapy.
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Pascal:08-0199373Le document en format XML
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<series><title level="j" type="main">Movement disorders</title>
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<term>Dopamine</term>
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<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
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<term>Mort cellulaire</term>
<term>Mésencéphale</term>
<term>Neurone</term>
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<front><div type="abstract" xml:lang="en">Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra. We observed more widespread dopamine neuron loss in the extranigral A10 midbrain cell groups in PSP compared with PD. These cell groups innervate subcortical and cortical regions and may be required for adequate response to levodopa therapy.</div>
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