Excessive Dopamine Neuron Loss in Progressive Supranuclear Palsy
Identifieur interne : 001298 ( PascalFrancis/Corpus ); précédent : 001297; suivant : 001299Excessive Dopamine Neuron Loss in Progressive Supranuclear Palsy
Auteurs : Karen E. Murphy ; Tanya Karaconji ; Craig D. Hardman ; Glenda M. HallidaySource :
- Movement disorders [ 0885-3185 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra. We observed more widespread dopamine neuron loss in the extranigral A10 midbrain cell groups in PSP compared with PD. These cell groups innervate subcortical and cortical regions and may be required for adequate response to levodopa therapy.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 08-0199373 INIST |
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ET : | Excessive Dopamine Neuron Loss in Progressive Supranuclear Palsy |
AU : | MURPHY (Karen E.); KARACONJI (Tanya); HARDMAN (Craig D.); HALLIDAY (Glenda M.) |
AF : | Prince of Wales Medical Research Institute/Randwick/Australie (1 aut., 4 aut.); Department of Anatomy, School of Medical Sciences, University of New South Wales/Sydney/Australie (2 aut., 3 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 4; Pp. 607-610; Bibl. 8 ref. |
LA : | Anglais |
EA : | Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra. We observed more widespread dopamine neuron loss in the extranigral A10 midbrain cell groups in PSP compared with PD. These cell groups innervate subcortical and cortical regions and may be required for adequate response to levodopa therapy. |
CC : | 002B17; 002B17G |
FD : | Maladie de Parkinson; Pathologie du système nerveux; Dopamine; Mort cellulaire; Mésencéphale; Neurone |
FG : | Catécholamine; Neurotransmetteur; Système nerveux central; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
ED : | Parkinson disease; Nervous system diseases; Dopamine; Cell death; Midbrain; Neuron |
EG : | Catecholamine; Neurotransmitter; Central nervous system; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Parkinson enfermedad; Sistema nervioso patología; Dopamina; Muerte celular; Mesencéfalo; Neurona |
LO : | INIST-20953.354000183361080200 |
ID : | 08-0199373 |
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Pascal:08-0199373Le document en format XML
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<front><div type="abstract" xml:lang="en">Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra. We observed more widespread dopamine neuron loss in the extranigral A10 midbrain cell groups in PSP compared with PD. These cell groups innervate subcortical and cortical regions and may be required for adequate response to levodopa therapy.</div>
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<ET>Excessive Dopamine Neuron Loss in Progressive Supranuclear Palsy</ET>
<AU>MURPHY (Karen E.); KARACONJI (Tanya); HARDMAN (Craig D.); HALLIDAY (Glenda M.)</AU>
<AF>Prince of Wales Medical Research Institute/Randwick/Australie (1 aut., 4 aut.); Department of Anatomy, School of Medical Sciences, University of New South Wales/Sydney/Australie (2 aut., 3 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
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<LA>Anglais</LA>
<EA>Progressive supranuclear palsy (PSP) and Parkinson's disease (PD) differ in their response to dopaminergic replacement therapies, despite having a similar degree of neuronal degeneration in the dopaminergic substantia nigra. We observed more widespread dopamine neuron loss in the extranigral A10 midbrain cell groups in PSP compared with PD. These cell groups innervate subcortical and cortical regions and may be required for adequate response to levodopa therapy.</EA>
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