Kinematic and electromyographic tools for characterizing movement disorders in mice
Identifieur interne : 001C15 ( Main/Curation ); précédent : 001C14; suivant : 001C16Kinematic and electromyographic tools for characterizing movement disorders in mice
Auteurs : Hans C. Scholle [Allemagne] ; H. A. Jinnah [États-Unis] ; Dirk Arnold [Allemagne] ; Frank H. W. Biedermann [Allemagne] ; Bernd Faenger [Allemagne] ; Roland Grassme [Allemagne] ; Ellen J. Hess [États-Unis] ; Nikolaus P. Schumann [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-02-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Age Factors, Animal, Animal model, Animals, Ataxia, Biomechanical Phenomena, Calcium Channels, N-Type, Calcium Channels, P-Type (genetics), Calcium Channels, Q-Type (genetics), Disease Models, Animal, Dystonia, Electromyography, Electromyography (methods), Exercise Test (methods), Female, Kinematics, Locomotion (genetics), Mice, Mice, Transgenic, Mouse, Movement Disorders (genetics), Movement Disorders (pathology), Movement Disorders (physiopathology), Muscle, Skeletal (abnormalities), Muscle, Skeletal (physiopathology), Mutation (genetics), Nervous system diseases, Time Factors, Videotape Recording, animal models, ataxia, dystonia, electromyography, video kinematics.
- MESH :
- chemical , genetics : Calcium Channels, P-Type, Calcium Channels, Q-Type.
- chemical : Calcium Channels, N-Type.
- abnormalities : Muscle, Skeletal.
- genetics : Locomotion, Movement Disorders, Mutation.
- methods : Electromyography, Exercise Test.
- pathology : Movement Disorders.
- physiopathology : Movement Disorders, Muscle, Skeletal.
- Age Factors, Animals, Biomechanical Phenomena, Disease Models, Animal, Female, Mice, Mice, Transgenic, Time Factors, Videotape Recording.
Abstract
Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high‐speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans. © 2010 Movement Disorder Society
Url:
- https://api.istex.fr/document/A4D7A3DA95EEF025E65E333707FF477C1B3915B4/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925152
DOI: 10.1002/mds.22933
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000451
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000451
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000894
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000078
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000078
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000333
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001A22
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001A22
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001811
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002980
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :002980
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002980
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :002051
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000C35
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :002084
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000994
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :002581
Links to Exploration step
ISTEX:A4D7A3DA95EEF025E65E333707FF477C1B3915B4Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Kinematic and electromyographic tools for characterizing movement disorders in mice</title>
<author><name sortKey="Scholle, Hans C" sort="Scholle, Hans C" uniqKey="Scholle H" first="Hans C." last="Scholle">Hans C. Scholle</name>
</author>
<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
</author>
<author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name>
</author>
<author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H. W." last="Biedermann">Frank H. W. Biedermann</name>
</author>
<author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name>
</author>
<author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name>
</author>
<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
</author>
<author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P." last="Schumann">Nikolaus P. Schumann</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:A4D7A3DA95EEF025E65E333707FF477C1B3915B4</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.22933</idno>
<idno type="url">https://api.istex.fr/document/A4D7A3DA95EEF025E65E333707FF477C1B3915B4/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000451</idno>
<idno type="wicri:Area/Istex/Curation">000451</idno>
<idno type="wicri:Area/Istex/Checkpoint">000894</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Scholle H:kinematic:and:electromyographic</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925152</idno>
<idno type="RBID">PMC:2925152</idno>
<idno type="wicri:Area/Pmc/Corpus">000078</idno>
<idno type="wicri:Area/Pmc/Curation">000078</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000333</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001A22</idno>
<idno type="wicri:Area/PubMed/Curation">001A22</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001811</idno>
<idno type="wicri:Area/Ncbi/Merge">002980</idno>
<idno type="wicri:Area/Ncbi/Curation">002980</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002980</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Scholle H:kinematic:and:electromyographic</idno>
<idno type="wicri:Area/Main/Merge">002051</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:10-0161566</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000C35</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002084</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000994</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Scholle H:kinematic:and:electromyographic</idno>
<idno type="wicri:Area/Main/Merge">002581</idno>
<idno type="wicri:Area/Main/Curation">001C15</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Kinematic and electromyographic tools for characterizing movement disorders in mice</title>
<author><name sortKey="Scholle, Hans C" sort="Scholle, Hans C" uniqKey="Scholle H" first="Hans C." last="Scholle">Hans C. Scholle</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology and Human Genetics, Emory University, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H. W." last="Biedermann">Frank H. W. Biedermann</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt</wicri:regionArea>
<wicri:noRegion>Erfurt</wicri:noRegion>
<wicri:noRegion>Erfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Pharmacology and Neurology, Emory University, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P." last="Schumann">Nikolaus P. Schumann</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-02-15">2010-02-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="265">265</biblScope>
<biblScope unit="page" to="274">274</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">A4D7A3DA95EEF025E65E333707FF477C1B3915B4</idno>
<idno type="DOI">10.1002/mds.22933</idno>
<idno type="ArticleID">MDS22933</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term>
<term>Animal</term>
<term>Animal model</term>
<term>Animals</term>
<term>Ataxia</term>
<term>Biomechanical Phenomena</term>
<term>Calcium Channels, N-Type</term>
<term>Calcium Channels, P-Type (genetics)</term>
<term>Calcium Channels, Q-Type (genetics)</term>
<term>Disease Models, Animal</term>
<term>Dystonia</term>
<term>Electromyography</term>
<term>Electromyography (methods)</term>
<term>Exercise Test (methods)</term>
<term>Female</term>
<term>Kinematics</term>
<term>Locomotion (genetics)</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Mouse</term>
<term>Movement Disorders (genetics)</term>
<term>Movement Disorders (pathology)</term>
<term>Movement Disorders (physiopathology)</term>
<term>Muscle, Skeletal (abnormalities)</term>
<term>Muscle, Skeletal (physiopathology)</term>
<term>Mutation (genetics)</term>
<term>Nervous system diseases</term>
<term>Time Factors</term>
<term>Videotape Recording</term>
<term>animal models</term>
<term>ataxia</term>
<term>dystonia</term>
<term>electromyography</term>
<term>video kinematics</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Calcium Channels, P-Type</term>
<term>Calcium Channels, Q-Type</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Calcium Channels, N-Type</term>
</keywords>
<keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Locomotion</term>
<term>Movement Disorders</term>
<term>Mutation</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electromyography</term>
<term>Exercise Test</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Movement Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Movement Disorders</term>
<term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age Factors</term>
<term>Animals</term>
<term>Biomechanical Phenomena</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Time Factors</term>
<term>Videotape Recording</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animal</term>
<term>Ataxie</term>
<term>Cinématique</term>
<term>Dystonie</term>
<term>Electromyographie</term>
<term>Modèle animal</term>
<term>Pathologie du système nerveux</term>
<term>Souris</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high‐speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans. © 2010 Movement Disorder Society</div>
</front>
</TEI>
<double idat="0885-3185:2010:Scholle H:kinematic:and:electromyographic"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice</title>
<author><name sortKey="Scholle, Hans C" sort="Scholle, Hans C" uniqKey="Scholle H" first="Hans C." last="Scholle">Hans C. Scholle</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Friedrich Schiller University</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Departments of Neurology and Human Genetics, Emory University</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Friedrich Schiller University</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H. W." last="Biedermann">Frank H. W. Biedermann</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Friedrich Schiller University</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Friedrich Schiller University</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Friedrich Schiller University</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten</s1>
<s2>Erfurt</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Erfurt</wicri:noRegion>
<wicri:noRegion>Berufsgenossenschaft Nahrungsmittel und Gaststätten</wicri:noRegion>
<wicri:noRegion>Erfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Departments of Pharmacology and Neurology, Emory University</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P." last="Schumann">Nikolaus P. Schumann</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Friedrich Schiller University</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0161566</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0161566 INIST</idno>
<idno type="RBID">Pascal:10-0161566</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000C35</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002084</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000994</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Scholle H:kinematic:and:electromyographic</idno>
<idno type="wicri:Area/Main/Merge">002581</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice</title>
<author><name sortKey="Scholle, Hans C" sort="Scholle, Hans C" uniqKey="Scholle H" first="Hans C." last="Scholle">Hans C. Scholle</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Friedrich Schiller University</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Departments of Neurology and Human Genetics, Emory University</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Friedrich Schiller University</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H. W." last="Biedermann">Frank H. W. Biedermann</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Friedrich Schiller University</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Friedrich Schiller University</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Friedrich Schiller University</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten</s1>
<s2>Erfurt</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Erfurt</wicri:noRegion>
<wicri:noRegion>Berufsgenossenschaft Nahrungsmittel und Gaststätten</wicri:noRegion>
<wicri:noRegion>Erfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Departments of Pharmacology and Neurology, Emory University</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P." last="Schumann">Nikolaus P. Schumann</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University</s1>
<s2>Jena</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Friedrich Schiller University</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Animal model</term>
<term>Ataxia</term>
<term>Dystonia</term>
<term>Electromyography</term>
<term>Kinematics</term>
<term>Mouse</term>
<term>Nervous system diseases</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Ataxie</term>
<term>Dystonie</term>
<term>Pathologie du système nerveux</term>
<term>Cinématique</term>
<term>Animal</term>
<term>Souris</term>
<term>Modèle animal</term>
<term>Electromyographie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high-speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Kinematic and electromyographic tools for characterizing movement disorders in mice</title>
<author><name sortKey="Scholle, Hans C" sort="Scholle, Hans C" uniqKey="Scholle H" first="Hans C." last="Scholle">Hans C. Scholle</name>
</author>
<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
</author>
<author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name>
</author>
<author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H. W." last="Biedermann">Frank H. W. Biedermann</name>
</author>
<author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name>
</author>
<author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name>
</author>
<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
</author>
<author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P." last="Schumann">Nikolaus P. Schumann</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:A4D7A3DA95EEF025E65E333707FF477C1B3915B4</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.22933</idno>
<idno type="url">https://api.istex.fr/document/A4D7A3DA95EEF025E65E333707FF477C1B3915B4/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000451</idno>
<idno type="wicri:Area/Istex/Curation">000451</idno>
<idno type="wicri:Area/Istex/Checkpoint">000894</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Scholle H:kinematic:and:electromyographic</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925152</idno>
<idno type="RBID">PMC:2925152</idno>
<idno type="wicri:Area/Pmc/Corpus">000078</idno>
<idno type="wicri:Area/Pmc/Curation">000078</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000333</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001A22</idno>
<idno type="wicri:Area/PubMed/Curation">001A22</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001811</idno>
<idno type="wicri:Area/Ncbi/Merge">002980</idno>
<idno type="wicri:Area/Ncbi/Curation">002980</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002980</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Scholle H:kinematic:and:electromyographic</idno>
<idno type="wicri:Area/Main/Merge">002051</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Kinematic and electromyographic tools for characterizing movement disorders in mice</title>
<author><name sortKey="Scholle, Hans C" sort="Scholle, Hans C" uniqKey="Scholle H" first="Hans C." last="Scholle">Hans C. Scholle</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology and Human Genetics, Emory University, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H. W." last="Biedermann">Frank H. W. Biedermann</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt</wicri:regionArea>
<wicri:noRegion>Erfurt</wicri:noRegion>
<wicri:noRegion>Erfurt</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Pharmacology and Neurology, Emory University, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P." last="Schumann">Nikolaus P. Schumann</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
<wicri:noRegion>Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-02-15">2010-02-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="265">265</biblScope>
<biblScope unit="page" to="274">274</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">A4D7A3DA95EEF025E65E333707FF477C1B3915B4</idno>
<idno type="DOI">10.1002/mds.22933</idno>
<idno type="ArticleID">MDS22933</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term>
<term>Animals</term>
<term>Biomechanical Phenomena</term>
<term>Calcium Channels, N-Type</term>
<term>Calcium Channels, P-Type (genetics)</term>
<term>Calcium Channels, Q-Type (genetics)</term>
<term>Disease Models, Animal</term>
<term>Electromyography (methods)</term>
<term>Exercise Test (methods)</term>
<term>Female</term>
<term>Locomotion (genetics)</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Movement Disorders (genetics)</term>
<term>Movement Disorders (pathology)</term>
<term>Movement Disorders (physiopathology)</term>
<term>Muscle, Skeletal (abnormalities)</term>
<term>Muscle, Skeletal (physiopathology)</term>
<term>Mutation (genetics)</term>
<term>Time Factors</term>
<term>Videotape Recording</term>
<term>animal models</term>
<term>ataxia</term>
<term>dystonia</term>
<term>electromyography</term>
<term>video kinematics</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Calcium Channels, P-Type</term>
<term>Calcium Channels, Q-Type</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Calcium Channels, N-Type</term>
</keywords>
<keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Locomotion</term>
<term>Movement Disorders</term>
<term>Mutation</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electromyography</term>
<term>Exercise Test</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Movement Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Movement Disorders</term>
<term>Muscle, Skeletal</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age Factors</term>
<term>Animals</term>
<term>Biomechanical Phenomena</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Mice</term>
<term>Mice, Transgenic</term>
<term>Time Factors</term>
<term>Videotape Recording</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high‐speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans. © 2010 Movement Disorder Society</div>
</front>
</TEI>
</ISTEX>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C15 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001C15 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:A4D7A3DA95EEF025E65E333707FF477C1B3915B4 |texte= Kinematic and electromyographic tools for characterizing movement disorders in mice }}
This area was generated with Dilib version V0.6.23. |