Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice
Identifieur interne : 002980 ( Ncbi/Merge ); précédent : 002979; suivant : 002981Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice
Auteurs : Hans C. Scholle [Allemagne] ; H. A. Jinnah [États-Unis] ; Dirk Arnold [Allemagne] ; Frank H. W. Biedermann [Allemagne] ; Bernd Faenger [Allemagne] ; Roland Grassme [Allemagne] ; Ellen J. Hess [États-Unis] ; Nikolaus P. Schumann [Allemagne]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
English descriptors
- KwdEn :
- Age Factors, Animals, Biomechanical Phenomena, Calcium Channels, N-Type, Calcium Channels, P-Type (genetics), Calcium Channels, Q-Type (genetics), Disease Models, Animal, Electromyography (methods), Exercise Test (methods), Female, Locomotion (genetics), Mice, Mice, Transgenic, Movement Disorders (genetics), Movement Disorders (pathology), Movement Disorders (physiopathology), Muscle, Skeletal (abnormalities), Muscle, Skeletal (physiopathology), Mutation (genetics), Time Factors, Videotape Recording.
- MESH :
- chemical , genetics : Calcium Channels, P-Type, Calcium Channels, Q-Type.
- chemical : Calcium Channels, N-Type.
- abnormalities : Muscle, Skeletal.
- genetics : Locomotion, Movement Disorders, Mutation.
- methods : Electromyography, Exercise Test.
- pathology : Movement Disorders.
- physiopathology : Movement Disorders, Muscle, Skeletal.
- Age Factors, Animals, Biomechanical Phenomena, Disease Models, Animal, Female, Mice, Mice, Transgenic, Time Factors, Videotape Recording.
Abstract
Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high-speed video kinematics with multi-channel EMG to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris (BF) and vastus lateralis (VL), and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the BF and VL followed by more sustained co-activation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice, and for how they may be compared with similar disorders of humans.
Url:
DOI: 10.1002/mds.22933
PubMed: 20077474
PubMed Central: 2925152
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Scholle</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name><affiliation wicri:level="2"><nlm:aff id="A2">Departments of Neurology & Human Genetics, Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology & Human Genetics, Emory University, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H. W." last="Biedermann">Frank H. W. Biedermann</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt</wicri:regionArea><wicri:noRegion>Erfurt</wicri:noRegion><wicri:noRegion>Erfurt</wicri:noRegion><wicri:noRegion>Erfurt</wicri:noRegion></affiliation></author><author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name><affiliation wicri:level="2"><nlm:aff id="A3">Departments of Pharmacology & Neurology, Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pharmacology & Neurology, Emory University, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P." last="Schumann">Nikolaus P. Schumann</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Animals</term><term>Biomechanical Phenomena</term><term>Calcium Channels, N-Type</term><term>Calcium Channels, P-Type (genetics)</term><term>Calcium Channels, Q-Type (genetics)</term><term>Disease Models, Animal</term><term>Electromyography (methods)</term><term>Exercise Test (methods)</term><term>Female</term><term>Locomotion (genetics)</term><term>Mice</term><term>Mice, Transgenic</term><term>Movement Disorders (genetics)</term><term>Movement Disorders (pathology)</term><term>Movement Disorders (physiopathology)</term><term>Muscle, Skeletal (abnormalities)</term><term>Muscle, Skeletal (physiopathology)</term><term>Mutation (genetics)</term><term>Time Factors</term><term>Videotape Recording</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Calcium Channels, P-Type</term><term>Calcium Channels, Q-Type</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Calcium Channels, N-Type</term></keywords><keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Locomotion</term><term>Movement Disorders</term><term>Mutation</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electromyography</term><term>Exercise Test</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Movement Disorders</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Animals</term><term>Biomechanical Phenomena</term><term>Disease Models, Animal</term><term>Female</term><term>Mice</term><term>Mice, Transgenic</term><term>Time Factors</term><term>Videotape Recording</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high-speed video kinematics with multi-channel EMG to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris (BF) and vastus lateralis (VL), and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the BF and VL followed by more sustained co-activation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice, and for how they may be compared with similar disorders of humans.</p></div></front></TEI><double pmid="20077474"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice</title><author><name sortKey="Scholle, Hans C" sort="Scholle, Hans C" uniqKey="Scholle H" first="Hans C." last="Scholle">Hans C. Scholle</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name><affiliation wicri:level="2"><nlm:aff id="A2">Departments of Neurology & Human Genetics, Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology & Human Genetics, Emory University, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H. W." last="Biedermann">Frank H. W. Biedermann</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt</wicri:regionArea><wicri:noRegion>Erfurt</wicri:noRegion><wicri:noRegion>Erfurt</wicri:noRegion><wicri:noRegion>Erfurt</wicri:noRegion></affiliation></author><author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name><affiliation wicri:level="2"><nlm:aff id="A3">Departments of Pharmacology & Neurology, Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pharmacology & Neurology, Emory University, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P." last="Schumann">Nikolaus P. Schumann</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20077474</idno><idno type="pmc">2925152</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925152</idno><idno type="RBID">PMC:2925152</idno><idno type="doi">10.1002/mds.22933</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000078</idno><idno type="wicri:Area/Pmc/Curation">000078</idno><idno type="wicri:Area/Pmc/Checkpoint">000333</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice</title><author><name sortKey="Scholle, Hans C" sort="Scholle, Hans C" uniqKey="Scholle H" first="Hans C." last="Scholle">Hans C. Scholle</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name><affiliation wicri:level="2"><nlm:aff id="A2">Departments of Neurology & Human Genetics, Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology & Human Genetics, Emory University, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H. W." last="Biedermann">Frank H. W. Biedermann</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt</wicri:regionArea><wicri:noRegion>Erfurt</wicri:noRegion><wicri:noRegion>Erfurt</wicri:noRegion><wicri:noRegion>Erfurt</wicri:noRegion></affiliation></author><author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name><affiliation wicri:level="2"><nlm:aff id="A3">Departments of Pharmacology & Neurology, Emory University, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Pharmacology & Neurology, Emory University, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P." last="Schumann">Nikolaus P. Schumann</name><affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high-speed video kinematics with multi-channel EMG to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris (BF) and vastus lateralis (VL), and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the BF and VL followed by more sustained co-activation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice, and for how they may be compared with similar disorders of humans.</p></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Kinematic and electromyographic tools for characterizing movement disorders in mice.</title><author><name sortKey="Scholle, Hans C" sort="Scholle, Hans C" uniqKey="Scholle H" first="Hans C" last="Scholle">Hans C. Scholle</name><affiliation wicri:level="1"><nlm:affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H A" last="Jinnah">H A Jinnah</name></author><author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name></author><author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H W" last="Biedermann">Frank H W. Biedermann</name></author><author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name></author><author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name></author><author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J" last="Hess">Ellen J. Hess</name></author><author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P" last="Schumann">Nikolaus P. Schumann</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.22933</idno><idno type="RBID">pubmed:20077474</idno><idno type="pmid">20077474</idno><idno type="wicri:Area/PubMed/Corpus">001A22</idno><idno type="wicri:Area/PubMed/Curation">001A22</idno><idno type="wicri:Area/PubMed/Checkpoint">001811</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Kinematic and electromyographic tools for characterizing movement disorders in mice.</title><author><name sortKey="Scholle, Hans C" sort="Scholle, Hans C" uniqKey="Scholle H" first="Hans C" last="Scholle">Hans C. Scholle</name><affiliation wicri:level="1"><nlm:affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H A" last="Jinnah">H A Jinnah</name></author><author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name></author><author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H W" last="Biedermann">Frank H W. Biedermann</name></author><author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name></author><author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name></author><author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J" last="Hess">Ellen J. Hess</name></author><author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P" last="Schumann">Nikolaus P. Schumann</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Animals</term><term>Biomechanical Phenomena</term><term>Calcium Channels, N-Type</term><term>Calcium Channels, P-Type (genetics)</term><term>Calcium Channels, Q-Type (genetics)</term><term>Disease Models, Animal</term><term>Electromyography (methods)</term><term>Exercise Test (methods)</term><term>Female</term><term>Locomotion (genetics)</term><term>Mice</term><term>Mice, Transgenic</term><term>Movement Disorders (genetics)</term><term>Movement Disorders (pathology)</term><term>Movement Disorders (physiopathology)</term><term>Muscle, Skeletal (abnormalities)</term><term>Muscle, Skeletal (physiopathology)</term><term>Mutation (genetics)</term><term>Time Factors</term><term>Videotape Recording</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Calcium Channels, P-Type</term><term>Calcium Channels, Q-Type</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Calcium Channels, N-Type</term></keywords><keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Locomotion</term><term>Movement Disorders</term><term>Mutation</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electromyography</term><term>Exercise Test</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Movement Disorders</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Animals</term><term>Biomechanical Phenomena</term><term>Disease Models, Animal</term><term>Female</term><term>Mice</term><term>Mice, Transgenic</term><term>Time Factors</term><term>Videotape Recording</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high-speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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