Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice
Identifieur interne : 000078 ( Pmc/Curation ); précédent : 000077; suivant : 000079Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice
Auteurs : Hans C. Scholle [Allemagne] ; H. A. Jinnah [États-Unis] ; Dirk Arnold [Allemagne] ; Frank H. W. Biedermann [Allemagne] ; Bernd Faenger [Allemagne] ; Roland Grassme [Allemagne] ; Ellen J. Hess [États-Unis] ; Nikolaus P. Schumann [Allemagne]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
Abstract
Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high-speed video kinematics with multi-channel EMG to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris (BF) and vastus lateralis (VL), and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the BF and VL followed by more sustained co-activation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice, and for how they may be compared with similar disorders of humans.
Url:
DOI: 10.1002/mds.22933
PubMed: 20077474
PubMed Central: 2925152
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000078
Links to Exploration step
PMC:2925152Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice</title>
<author><name sortKey="Scholle, Hans C" sort="Scholle, Hans C" uniqKey="Scholle H" first="Hans C." last="Scholle">Hans C. Scholle</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Departments of Neurology & Human Genetics, Emory University, Atlanta, GA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology & Human Genetics, Emory University, Atlanta, GA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H. W." last="Biedermann">Frank H. W. Biedermann</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Departments of Pharmacology & Neurology, Emory University, Atlanta, GA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Pharmacology & Neurology, Emory University, Atlanta, GA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P." last="Schumann">Nikolaus P. Schumann</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20077474</idno>
<idno type="pmc">2925152</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925152</idno>
<idno type="RBID">PMC:2925152</idno>
<idno type="doi">10.1002/mds.22933</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000078</idno>
<idno type="wicri:Area/Pmc/Curation">000078</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice</title>
<author><name sortKey="Scholle, Hans C" sort="Scholle, Hans C" uniqKey="Scholle H" first="Hans C." last="Scholle">Hans C. Scholle</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Departments of Neurology & Human Genetics, Emory University, Atlanta, GA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology & Human Genetics, Emory University, Atlanta, GA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H. W." last="Biedermann">Frank H. W. Biedermann</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Departments of Pharmacology & Neurology, Emory University, Atlanta, GA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Pharmacology & Neurology, Emory University, Atlanta, GA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P." last="Schumann">Nikolaus P. Schumann</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high-speed video kinematics with multi-channel EMG to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris (BF) and vastus lateralis (VL), and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the BF and VL followed by more sustained co-activation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice, and for how they may be compared with similar disorders of humans.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5937</journal-id>
<journal-id journal-id-type="nlm-ta">Mov Disord</journal-id>
<journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title>
<issn pub-type="ppub">0885-3185</issn>
<issn pub-type="epub">1531-8257</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20077474</article-id>
<article-id pub-id-type="pmc">2925152</article-id>
<article-id pub-id-type="doi">10.1002/mds.22933</article-id>
<article-id pub-id-type="manuscript">NIHMS160636</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Scholle</surname>
<given-names>Hans C.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jinnah</surname>
<given-names>H. A.</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arnold</surname>
<given-names>Dirk</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Biedermann</surname>
<given-names>Frank H. W.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Faenger</surname>
<given-names>Bernd</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grassme</surname>
<given-names>Roland</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hess</surname>
<given-names>Ellen J.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schumann</surname>
<given-names>Nikolaus P.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Division Motor Research, Pathophysiology & Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</aff>
<aff id="A2"><label>2</label>
Departments of Neurology & Human Genetics, Emory University, Atlanta, GA, USA</aff>
<aff id="A3"><label>3</label>
Departments of Pharmacology & Neurology, Emory University, Atlanta, GA, USA</aff>
<aff id="A4"><label>4</label>
Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt, Germany</aff>
<author-notes><corresp id="cor1"><label>*</label>
<bold>Corresponding author:</bold>
H. A. Jinnah, MD, PhD, Emory University School of Medicine, Departments of Neurology & Human Genetics, 6305 Woodruff Memorial Building, Atlanta GA, 30322, USA, Phone: 404-727-9107, Fax: 404-712-8576, <email>hjinnah@emory.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>23</day>
<month>6</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub"><day>15</day>
<month>2</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>15</day>
<month>2</month>
<year>2011</year>
</pub-date>
<volume>25</volume>
<issue>3</issue>
<fpage>265</fpage>
<lpage>274</lpage>
<abstract><p id="P1">Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high-speed video kinematics with multi-channel EMG to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris (BF) and vastus lateralis (VL), and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the BF and VL followed by more sustained co-activation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice, and for how they may be compared with similar disorders of humans.</p>
</abstract>
<kwd-group><kwd>Ataxia</kwd>
<kwd>Dystonia</kwd>
<kwd>Animal Models</kwd>
<kwd>Electromyography</kwd>
<kwd>Video kinematics</kwd>
</kwd-group>
<contract-num rid="NS1">R01 NS040470-09
||NS</contract-num>
<contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke : NINDS</contract-sponsor>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000078 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000078 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:2925152 |texte= Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:20077474" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
![]() | This area was generated with Dilib version V0.6.23. | ![]() |