Kinematic and electromyographic tools for characterizing movement disorders in mice
Identifieur interne : 000451 ( Istex/Corpus ); précédent : 000450; suivant : 000452Kinematic and electromyographic tools for characterizing movement disorders in mice
Auteurs : Hans C. Scholle ; H. A. Jinnah ; Dirk Arnold ; Frank H. W. Biedermann ; Bernd Faenger ; Roland Grassme ; Ellen J. Hess ; Nikolaus P. SchumannSource :
- Movement Disorders [ 0885-3185 ] ; 2010-02-15.
English descriptors
- KwdEn :
Abstract
Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high‐speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22933
Links to Exploration step
ISTEX:A4D7A3DA95EEF025E65E333707FF477C1B3915B4Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Kinematic and electromyographic tools for characterizing movement disorders in mice</title><author><name sortKey="Scholle, Hans C" sort="Scholle, Hans C" uniqKey="Scholle H" first="Hans C." last="Scholle">Hans C. Scholle</name><affiliation><mods:affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</mods:affiliation></affiliation></author><author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name><affiliation><mods:affiliation>Departments of Neurology and Human Genetics, Emory University, Atlanta, Georgia, USA</mods:affiliation></affiliation></author><author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name><affiliation><mods:affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</mods:affiliation></affiliation></author><author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H. W." last="Biedermann">Frank H. W. Biedermann</name><affiliation><mods:affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</mods:affiliation></affiliation></author><author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name><affiliation><mods:affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</mods:affiliation></affiliation></author><author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name><affiliation><mods:affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name><affiliation><mods:affiliation>Departments of Pharmacology and Neurology, Emory University, Atlanta, Georgia, USA</mods:affiliation></affiliation></author><author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P." last="Schumann">Nikolaus P. Schumann</name><affiliation><mods:affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A4D7A3DA95EEF025E65E333707FF477C1B3915B4</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.22933</idno><idno type="url">https://api.istex.fr/document/A4D7A3DA95EEF025E65E333707FF477C1B3915B4/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000451</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Kinematic and electromyographic tools for characterizing movement disorders in mice</title><author><name sortKey="Scholle, Hans C" sort="Scholle, Hans C" uniqKey="Scholle H" first="Hans C." last="Scholle">Hans C. Scholle</name><affiliation><mods:affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</mods:affiliation></affiliation></author><author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H. A." last="Jinnah">H. A. Jinnah</name><affiliation><mods:affiliation>Departments of Neurology and Human Genetics, Emory University, Atlanta, Georgia, USA</mods:affiliation></affiliation></author><author><name sortKey="Arnold, Dirk" sort="Arnold, Dirk" uniqKey="Arnold D" first="Dirk" last="Arnold">Dirk Arnold</name><affiliation><mods:affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</mods:affiliation></affiliation></author><author><name sortKey="Biedermann, Frank H W" sort="Biedermann, Frank H W" uniqKey="Biedermann F" first="Frank H. W." last="Biedermann">Frank H. W. Biedermann</name><affiliation><mods:affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</mods:affiliation></affiliation></author><author><name sortKey="Faenger, Bernd" sort="Faenger, Bernd" uniqKey="Faenger B" first="Bernd" last="Faenger">Bernd Faenger</name><affiliation><mods:affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</mods:affiliation></affiliation></author><author><name sortKey="Grassme, Roland" sort="Grassme, Roland" uniqKey="Grassme R" first="Roland" last="Grassme">Roland Grassme</name><affiliation><mods:affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J." last="Hess">Ellen J. Hess</name><affiliation><mods:affiliation>Departments of Pharmacology and Neurology, Emory University, Atlanta, Georgia, USA</mods:affiliation></affiliation></author><author><name sortKey="Schumann, Nikolaus P" sort="Schumann, Nikolaus P" uniqKey="Schumann N" first="Nikolaus P." last="Schumann">Nikolaus P. Schumann</name><affiliation><mods:affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-02-15">2010-02-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="265">265</biblScope><biblScope unit="page" to="274">274</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A4D7A3DA95EEF025E65E333707FF477C1B3915B4</idno><idno type="DOI">10.1002/mds.22933</idno><idno type="ArticleID">MDS22933</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>animal models</term><term>ataxia</term><term>dystonia</term><term>electromyography</term><term>video kinematics</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high‐speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Hans C. Scholle MD, PhD</name><affiliations><json:string>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</json:string></affiliations></json:item><json:item><name>H.A. Jinnah MD, PhD</name><affiliations><json:string>Departments of Neurology and Human Genetics, Emory University, Atlanta, Georgia, USA</json:string></affiliations></json:item><json:item><name>Dirk Arnold PhD</name><affiliations><json:string>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</json:string></affiliations></json:item><json:item><name>Frank H.W. Biedermann MD</name><affiliations><json:string>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</json:string></affiliations></json:item><json:item><name>Bernd Faenger</name><affiliations><json:string>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</json:string></affiliations></json:item><json:item><name>Roland Grassme PhD</name><affiliations><json:string>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</json:string><json:string>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt, Germany</json:string></affiliations></json:item><json:item><name>Ellen J. Hess PhD</name><affiliations><json:string>Departments of Pharmacology and Neurology, Emory University, Atlanta, Georgia, USA</json:string></affiliations></json:item><json:item><name>Nikolaus P. Schumann MD</name><affiliations><json:string>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>ataxia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dystonia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>animal models</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>electromyography</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>video kinematics</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high‐speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>7.564</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1693</abstractCharCount><pdfWordCount>4624</pdfWordCount><pdfCharCount>30014</pdfCharCount><pdfPageCount>10</pdfPageCount><abstractWordCount>245</abstractWordCount></qualityIndicators><title>Kinematic and electromyographic tools for characterizing movement disorders in mice</title><genre><json:string>Serial article</json:string></genre><host><volume>25</volume><pages><total>10</total><last>274</last><first>265</first></pages><issn><json:string>0885-3185</json:string></issn><issue>3</issue><subject><json:item><value>Research Article</value></json:item></subject><genre></genre><language><json:string>unknown</json:string></language><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mds.22933</json:string></doi><id>A4D7A3DA95EEF025E65E333707FF477C1B3915B4</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/A4D7A3DA95EEF025E65E333707FF477C1B3915B4/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/A4D7A3DA95EEF025E65E333707FF477C1B3915B4/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A4D7A3DA95EEF025E65E333707FF477C1B3915B4/fulltext/tei"><teiHeader type="text"><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Kinematic and electromyographic tools for characterizing movement disorders in mice</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Wiley Subscription Services, Inc., A Wiley Company</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: None reported.</note><note>NIH - No. NS40470; No. NS33592;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Kinematic and electromyographic tools for characterizing movement disorders in mice</title><author><persName><forename type="first">Hans C.</forename><surname>Scholle</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</affiliation></author><author><persName><forename type="first">H.A.</forename><surname>Jinnah</surname><roleName type="degree">MD, PhD</roleName></persName><note type="correspondence"><p>Correspondence: Emory University School of Medicine, Departments of Neurology and Human Genetics, 6305 Woodruff Memorial Building, Atlanta GA, 30322, USA===</p></note><affiliation>Departments of Neurology and Human Genetics, Emory University, Atlanta, Georgia, USA</affiliation></author><author><persName><forename type="first">Dirk</forename><surname>Arnold</surname><roleName type="degree">PhD</roleName></persName><affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</affiliation></author><author><persName><forename type="first">Frank H.W.</forename><surname>Biedermann</surname><roleName type="degree">MD</roleName></persName><affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</affiliation></author><author><persName><forename type="first">Bernd</forename><surname>Faenger</surname></persName><affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</affiliation></author><author><persName><forename type="first">Roland</forename><surname>Grassme</surname><roleName type="degree">PhD</roleName></persName><affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</affiliation><affiliation>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt, Germany</affiliation></author><author><persName><forename type="first">Ellen J.</forename><surname>Hess</surname><roleName type="degree">PhD</roleName></persName><affiliation>Departments of Pharmacology and Neurology, Emory University, Atlanta, Georgia, USA</affiliation></author><author><persName><forename type="first">Nikolaus P.</forename><surname>Schumann</surname><roleName type="degree">MD</roleName></persName><affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-02-15"></date><biblScope unit="vol">25</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="265">265</biblScope><biblScope unit="page" to="274">274</biblScope></imprint></monogr><idno type="istex">A4D7A3DA95EEF025E65E333707FF477C1B3915B4</idno><idno type="DOI">10.1002/mds.22933</idno><idno type="ArticleID">MDS22933</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high‐speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>ataxia</term></item><item><term>dystonia</term></item><item><term>animal models</term></item><item><term>electromyography</term></item><item><term>video kinematics</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-12-08">Received</change><change when="2009-11-06">Registration</change><change when="2010-02-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/A4D7A3DA95EEF025E65E333707FF477C1B3915B4/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/mds.v25:3</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2010-02-15">15 February 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="40" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22933</doi><idGroup><id type="unit" value="MDS22933"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2010 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2008-12-08"></event><event type="manuscriptRevised" date="2009-10-09"></event><event type="manuscriptAccepted" date="2009-11-06"></event><event type="firstOnline" date="2010-01-13"></event><event type="publishedOnlineFinalForm" date="2010-02-24"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-01-13"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.3.2 mode:FullText" date="2014-07-01"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.2 mode:FullText" date="2014-07-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">265</numbering><numbering type="pageLast">274</numbering></numberingGroup><correspondenceTo>Emory University School of Medicine, Departments of Neurology and Human Genetics, 6305 Woodruff Memorial Building, Atlanta GA, 30322, USA===</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22933.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="42"></count><count type="wordTotal" number="5113"></count></countGroup><titleGroup><title type="main" xml:lang="en">Kinematic and electromyographic tools for characterizing movement disorders in mice<link href="#fn1"></link></title><title type="short" xml:lang="en">Analysis of Dystonia and Ataxia in Mice</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Hans C.</givenNames><familyName>Scholle</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>H.A.</givenNames><familyName>Jinnah</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>hjinnah@emory.edu</email></contactDetails></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Dirk</givenNames><familyName>Arnold</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Frank H.W.</givenNames><familyName>Biedermann</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Bernd</givenNames><familyName>Faenger</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1 #af4"><personName><givenNames>Roland</givenNames><familyName>Grassme</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Ellen J.</givenNames><familyName>Hess</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Nikolaus P.</givenNames><familyName>Schumann</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Departments of Neurology and Human Genetics, Emory University, Atlanta, Georgia, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Departments of Pharmacology and Neurology, Emory University, Atlanta, Georgia, USA</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="DE" type="organization"><unparsedAffiliation>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">ataxia</keyword><keyword xml:id="kwd2">dystonia</keyword><keyword xml:id="kwd3">animal models</keyword><keyword xml:id="kwd4">electromyography</keyword><keyword xml:id="kwd5">video kinematics</keyword></keywordGroup><fundingInfo><fundingAgency>NIH</fundingAgency><fundingNumber>NS40470</fundingNumber><fundingNumber>NS33592</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high‐speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><!--Version 0.6 générée le 3-12-2015--><mods version="3.6"><titleInfo lang="en"><title>Kinematic and electromyographic tools for characterizing movement disorders in mice</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Analysis of Dystonia and Ataxia in Mice</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Kinematic and electromyographic tools for characterizing movement disorders in mice</title></titleInfo><name type="personal"><namePart type="given">Hans C.</namePart><namePart type="family">Scholle</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.A.</namePart><namePart type="family">Jinnah</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Departments of Neurology and Human Genetics, Emory University, Atlanta, Georgia, USA</affiliation><description>Correspondence: Emory University School of Medicine, Departments of Neurology and Human Genetics, 6305 Woodruff Memorial Building, Atlanta GA, 30322, USA===</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dirk</namePart><namePart type="family">Arnold</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frank H.W.</namePart><namePart type="family">Biedermann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bernd</namePart><namePart type="family">Faenger</namePart><affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roland</namePart><namePart type="family">Grassme</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</affiliation><affiliation>Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten, Erfurt, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ellen J.</namePart><namePart type="family">Hess</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Departments of Pharmacology and Neurology, Emory University, Atlanta, Georgia, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nikolaus P.</namePart><namePart type="family">Schumann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University, Jena, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre authority="originalCategForm">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-02-15</dateIssued><dateCaptured encoding="w3cdtf">2008-12-08</dateCaptured><dateValid encoding="w3cdtf">2009-11-06</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="tables">2</extent><extent unit="references">42</extent><extent unit="words">5113</extent></physicalDescription><abstract lang="en">Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high‐speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><note type="funding">NIH - No. NS40470; No. NS33592; </note><subject lang="en"><genre>Keywords</genre><topic>ataxia</topic><topic>dystonia</topic><topic>animal models</topic><topic>electromyography</topic><topic>video kinematics</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>265</start><end>274</end><total>10</total></extent></part></relatedItem><identifier type="istex">A4D7A3DA95EEF025E65E333707FF477C1B3915B4</identifier><identifier type="DOI">10.1002/mds.22933</identifier><identifier type="ArticleID">MDS22933</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000451 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000451 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:A4D7A3DA95EEF025E65E333707FF477C1B3915B4
|texte= Kinematic and electromyographic tools for characterizing movement disorders in mice
}}
| This area was generated with Dilib version V0.6.23. |  |