MovDisordV3, PascalFrancis, Corpus, bibRecord, 000C35

Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice

Identifieur interne : 000C35 ( PascalFrancis/Corpus ); précédent : 000C34; suivant : 000C36

Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice

Auteurs : Hans C. Scholle ; H. A. Jinnah ; Dirk Arnold ; Frank H. W. Biedermann ; Bernd Faenger ; Roland Grassme ; Ellen J. Hess ; Nikolaus P. Schumann

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0161566

Descripteurs français

Pascal (Inist)
- Ataxie, Dystonie, Pathologie du système nerveux, Cinématique, Animal, Souris, Modèle animal, Electromyographie.

English descriptors

KwdEn :
- Animal, Animal model, Ataxia, Dystonia, Electromyography, Kinematics, Mouse, Nervous system diseases.

Abstract

Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high-speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`05`	`1`		`@1 FAENGER (Bernd)`
A11	`06`	`1`		`@1 GRASSME (Roland)`
A11	`07`	`1`		`@1 HESS (Ellen J.)`
A11	`08`	`1`		`@1 SCHUMANN (Nikolaus P.)`
A14	`01`			`@1 Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University @2 Jena @3 DEU @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 8 aut.`
A14	`02`			`@1 Departments of Neurology and Human Genetics, Emory University @2 Atlanta, Georgia @3 USA @Z 2 aut.`
A14	`03`			`@1 Departments of Pharmacology and Neurology, Emory University @2 Atlanta, Georgia @3 USA @Z 7 aut.`
A14	`04`			`@1 Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten @2 Erfurt @3 DEU @Z 6 aut.`
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C01	`01`		`ENG`	@0 Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high-speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans.
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C03	`01`	`X`	`ENG`	`@0 Ataxia @5 01`
C03	`01`	`X`	`SPA`	`@0 Ataxia @5 01`
C03	`02`	`X`	`FRE`	`@0 Dystonie @5 02`
C03	`02`	`X`	`ENG`	`@0 Dystonia @5 02`
C03	`02`	`X`	`SPA`	`@0 Distonía @5 02`
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C03	`03`	`X`	`ENG`	`@0 Nervous system diseases @5 03`
C03	`03`	`X`	`SPA`	`@0 Sistema nervioso patología @5 03`
C03	`04`	`X`	`FRE`	`@0 Cinématique @5 09`
C03	`04`	`X`	`ENG`	`@0 Kinematics @5 09`
C03	`04`	`X`	`SPA`	`@0 Cinemática @5 09`
C03	`05`	`X`	`FRE`	`@0 Animal @5 10`
C03	`05`	`X`	`ENG`	`@0 Animal @5 10`
C03	`05`	`X`	`SPA`	`@0 Animal @5 10`
C03	`06`	`X`	`FRE`	`@0 Souris @5 11`
C03	`06`	`X`	`ENG`	`@0 Mouse @5 11`
C03	`06`	`X`	`SPA`	`@0 Ratón @5 11`
C03	`07`	`X`	`FRE`	`@0 Modèle animal @5 12`
C03	`07`	`X`	`ENG`	`@0 Animal model @5 12`
C03	`07`	`X`	`SPA`	`@0 Modelo animal @5 12`
C03	`08`	`X`	`FRE`	`@0 Electromyographie @5 13`
C03	`08`	`X`	`ENG`	`@0 Electromyography @5 13`
C03	`08`	`X`	`SPA`	`@0 Electromiografía @5 13`
C07	`01`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`ENG`	`@0 Rodentia @2 NS`
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C07	`05`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 38`
C07	`05`	`X`	`ENG`	`@0 Central nervous system disease @5 38`
C07	`05`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 38`
C07	`06`	`X`	`FRE`	`@0 Trouble neurologique @5 40`
C07	`06`	`X`	`ENG`	`@0 Neurological disorder @5 40`
C07	`06`	`X`	`SPA`	`@0 Trastorno neurológico @5 40`
C07	`07`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 41`
C07	`07`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 41`
C07	`07`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 41`
C07	`08`	`X`	`FRE`	`@0 Mouvement involontaire @5 42`
C07	`08`	`X`	`ENG`	`@0 Involuntary movement @5 42`
C07	`08`	`X`	`SPA`	`@0 Movimiento involuntario @5 42`
C07	`09`	`X`	`FRE`	`@0 Pathologie du muscle strié @5 43`
C07	`09`	`X`	`ENG`	`@0 Striated muscle disease @5 43`
C07	`09`	`X`	`SPA`	`@0 Músculo estriado patología @5 43`
C07	`10`	`X`	`FRE`	`@0 Electrophysiologie @5 44`
C07	`10`	`X`	`ENG`	`@0 Electrophysiology @5 44`
C07	`10`	`X`	`SPA`	`@0 Electrofisiología @5 44`
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Format Inist (serveur)

NO :	PASCAL 10-0161566 INIST
ET :	Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice
AU :	SCHOLLE (Hans C.); JINNAH (H. A.); ARNOLD (Dirk); BIEDERMANN (Frank H. W.); FAENGER (Bernd); GRASSME (Roland); HESS (Ellen J.); SCHUMANN (Nikolaus P.)
AF :	Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University/Jena/Allemagne (1 aut., 3 aut., 4 aut., 5 aut., 6 aut., 8 aut.); Departments of Neurology and Human Genetics, Emory University/Atlanta, Georgia/Etats-Unis (2 aut.); Departments of Pharmacology and Neurology, Emory University/Atlanta, Georgia/Etats-Unis (7 aut.); Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten/Erfurt/Allemagne (6 aut.)
DT :	Publication en série; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 3; Pp. 265-274; Bibl. 42 ref.
LA :	Anglais
EA :	Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high-speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans.
CC :	002B17; 002B17A01
FD :	Ataxie; Dystonie; Pathologie du système nerveux; Cinématique; Animal; Souris; Modèle animal; Electromyographie
FG :	Rodentia; Mammalia; Vertebrata; Pathologie de l'encéphale; Pathologie du système nerveux central; Trouble neurologique; Syndrome extrapyramidal; Mouvement involontaire; Pathologie du muscle strié; Electrophysiologie
ED :	Ataxia; Dystonia; Nervous system diseases; Kinematics; Animal; Mouse; Animal model; Electromyography
EG :	Rodentia; Mammalia; Vertebrata; Cerebral disorder; Central nervous system disease; Neurological disorder; Extrapyramidal syndrome; Involuntary movement; Striated muscle disease; Electrophysiology
SD :	Ataxia; Distonía; Sistema nervioso patología; Cinemática; Animal; Ratón; Modelo animal; Electromiografía
LO :	INIST-20953.354000181820230030
ID :	10-0161566

Links to Exploration step

Pascal:10-0161566

Le document en format XML

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<series><title level="j" type="main">Movement disorders</title>
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<term>Animal model</term>
<term>Ataxia</term>
<term>Dystonia</term>
<term>Electromyography</term>
<term>Kinematics</term>
<term>Mouse</term>
<term>Nervous system diseases</term>
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<term>Dystonie</term>
<term>Pathologie du   système nerveux</term>
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<term>Souris</term>
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<front><div type="abstract" xml:lang="en">Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high-speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans.</div>
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<fA14 i1="01"><s1>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University</s1>
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<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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<fA14 i1="02"><s1>Departments of Neurology and Human Genetics, Emory University</s1>
<s2>Atlanta, Georgia</s2>
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<sZ>2 aut.</sZ>
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<ET>Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice</ET>
<AU>SCHOLLE (Hans C.); JINNAH (H. A.); ARNOLD (Dirk); BIEDERMANN (Frank H. W.); FAENGER (Bernd); GRASSME (Roland); HESS (Ellen J.); SCHUMANN (Nikolaus P.)</AU>
<AF>Division Motor Research, Pathophysiology and Biomechanics, Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Friedrich Schiller University/Jena/Allemagne (1 aut., 3 aut., 4 aut., 5 aut., 6 aut., 8 aut.); Departments of Neurology and Human Genetics, Emory University/Atlanta, Georgia/Etats-Unis (2 aut.); Departments of Pharmacology and Neurology, Emory University/Atlanta, Georgia/Etats-Unis (7 aut.); Prevention Department, Berufsgenossenschaft Nahrungsmittel und Gaststätten/Erfurt/Allemagne (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 3; Pp. 265-274; Bibl. 42 ref.</SO>
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<EA>Increasing interest in rodent models for movement disorders has led to an increasing need for more accurate and precise methods for both delineating the nature of abnormal movements and measuring their severity. These studies describe application of simultaneous high-speed video kinematics with multichannel electromyography (EMG) to characterize the movement disorder exhibited by tottering mutant mice. These mice provide a uniquely valuable model, because they exhibit paroxysmal dystonia superimposed on mild baseline ataxia, permitting the examination of these two different problems within the same animals. At baseline with mild ataxia, the mutants exhibited poorly coordinated movements with increased variation of stance and swing times, and slower spontaneous walking velocities. The corresponding EMG showed reduced mean amplitudes of biceps femoris and vastus lateralis, and poorly modulated EMG activities during the step cycle. Attacks of paroxysmal dystonia were preceded by trains of EMG bursts with doublets and triplets simultaneously in the biceps femoris and vastus lateralis followed by more sustained coactivation. These EMG characteristics are consistent with the clinical phenomenology of the motor phenotype of tottering mice as a baseline of mild ataxia with intermittent attacks of paroxysmal dystonia. The EMG characteristics of ataxia and dystonia in the tottering mice also are consistent with EMG studies of other ataxic or dystonic animals and humans. These studies provide insights into how these methods can be used for delineating movement disorders in mice and for how they may be compared with similar disorders of humans.</EA>
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<FD>Ataxie; Dystonie; Pathologie du   système nerveux; Cinématique; Animal; Souris; Modèle animal; Electromyographie</FD>
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<ED>Ataxia; Dystonia; Nervous system diseases; Kinematics; Animal; Mouse; Animal model; Electromyography</ED>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice

Kinematic and Electromyographic Tools for Characterizing Movement Disorders in Mice

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