LymphedemaV1, Main, Curation, bibRecord, 008A54

P‐16 Treatment of Malassezia otitis in dogs: a comparative field trial

Identifieur interne : 008A54 ( Main/Curation ); précédent : 008A53; suivant : 008A55

P‐16 Treatment of Malassezia otitis in dogs: a comparative field trial

Source :

Veterinary Dermatology [ 0959-4493 ] ; 2004-08.

RBID : ISTEX:ED5FFEBA40BB80269B46F8D83FEE7E36971B1863

Abstract

Otitis externa (OE) is a very common disease of dogs. Various treatments are available for OE, but most commercial preparations contain a mixture of antifungal, anti‐inflammatory drugs and antibiotic agents. The aim of this study was to evaluate if a commercial product containing clotrimazole, marbofloxacin and dexamethasone (Aurizon®) was more effective than the use of a topical antifungal agent econazole (Daktarin®) used alone to treat Malassezia otitis. Dogs presenting with bilateral OE and numerous yeasts on cytological examination were included. Twenty dogs aged from 1 to 14 years old were treated in this trial (40 ears, 20 in each group). Each case was treated with Aurizon® (four drops) in one ear and Daktarin® in the other ear. Criteria analysed were pruritus (visual analogue scale), erythema, amount of cerumen, and the number of yeasts on cytologic smears. All animals demonstrated a good improvement in Malassezia counts after either treatment. Significant differences were noted in favour of Aurizon® for erythema, cerumen, and pruritus on various days of evaluation. This study demonstrated the superiority of a mixture of corticosteroids and antifungal agent in comparison with an antifungal agent used alone for the treatment of Malassezia OE. Funding: Self‐funded.

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DOI: 10.1111/j.1365-3164.2004.00414_16.x

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ISTEX:ED5FFEBA40BB80269B46F8D83FEE7E36971B1863

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<front><div type="abstract" xml:lang="en">Otitis externa (OE) is a very common disease of dogs. Various treatments are available for OE, but most commercial preparations contain a mixture of antifungal, anti‐inflammatory drugs and antibiotic agents. The aim of this study was to evaluate if a commercial product containing clotrimazole, marbofloxacin and dexamethasone (Aurizon®) was more effective than the use of a topical antifungal agent econazole (Daktarin®) used alone to treat Malassezia otitis. Dogs presenting with bilateral OE and numerous yeasts on cytological examination were included. Twenty dogs aged from 1 to 14 years old were treated in this trial (40 ears, 20 in each group). Each case was treated with Aurizon® (four drops) in one ear and Daktarin® in the other ear. Criteria analysed were pruritus (visual analogue scale), erythema, amount of cerumen, and the number of yeasts on cytologic smears. All animals demonstrated a good improvement in Malassezia counts after either treatment. Significant differences were noted in favour of Aurizon® for erythema, cerumen, and pruritus on various days of evaluation. This study demonstrated the superiority of a mixture of corticosteroids and antifungal agent in comparison with an antifungal agent used alone for the treatment of Malassezia OE. Funding: Self‐funded.</div>
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<front><div type="abstract" xml:lang="en">Otitis externa (OE) is a very common disease of dogs. Various treatments are available for OE, but most commercial preparations contain a mixture of antifungal, anti‐inflammatory drugs and antibiotic agents. The aim of this study was to evaluate if a commercial product containing clotrimazole, marbofloxacin and dexamethasone (Aurizon®) was more effective than the use of a topical antifungal agent econazole (Daktarin®) used alone to treat Malassezia otitis. Dogs presenting with bilateral OE and numerous yeasts on cytological examination were included. Twenty dogs aged from 1 to 14 years old were treated in this trial (40 ears, 20 in each group). Each case was treated with Aurizon® (four drops) in one ear and Daktarin® in the other ear. Criteria analysed were pruritus (visual analogue scale), erythema, amount of cerumen, and the number of yeasts on cytologic smears. All animals demonstrated a good improvement in Malassezia counts after either treatment. Significant differences were noted in favour of Aurizon® for erythema, cerumen, and pruritus on various days of evaluation. This study demonstrated the superiority of a mixture of corticosteroids and antifungal agent in comparison with an antifungal agent used alone for the treatment of Malassezia OE. Funding: Self‐funded.</div>
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<front><div type="abstract" xml:lang="en">The purpose of this study was to determine whether tacrolimus ointment (Protopic) decreased the severity of localized lesions of canine atopic dermatitis (AD). Twenty dogs with AD were enrolled if they exhibited skin lesions localized to both front metacarpi. Each foot was randomized to be treated either with 0.1% tacrolimus or placebo (vaseline) ointment twice daily for 6 weeks. The nature of treatment for each foot lesion was concealed from the clinician. Before, and every 2 weeks during the study, erythema, lichenification, oozing and excoriations each were graded on a 10‐point scale (maximal total score: 40). The primary outcome measures consisted of the percentage reduction from baseline of lesional scores, and the number of subjects whose scores had decreased by 50% or greater by the end of the study. Intent‐to‐treat analyses were used. At the beginning of the study, lesional scores were not significantly different between treatment groups. After 6 weeks, the percentage reduction from baseline scores was higher for tacrolimus‐treated sites [median: 63% (95% CI: 39–67)] than for placebo‐treated feet [3% (‐2‐13)] (paired t‐test; P < 0.0001). When tacrolimus was applied, lesions decreased by 50% or greater in 15 dogs (75%), while this benchmark was not reached for any placebo‐treated feet (Fisher's exact test; P < 0.0001). Adverse drug events consisted of minor irritation in some dogs treated with tacrolimus. Results of this randomized, controlled trial suggest that the daily application of 0.1% tacrolimus ointment is useful for reducing the severity of localized skin lesions of canine AD. Funding: Self‐funded.</div>
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<front><div type="abstract" xml:lang="en">The purpose of this study was to determine whether doxycycline (Ronaxan) decreased the severity of localized lesions of canine acne. Dogs were enrolled if they exhibited skin lesions localized to the chin compatible with canine acne, and if cytological smears showed a bacterial invasion and bacteriological samples grew Staphylococcus intermedius colonies. Demodicosis and dermatophytosis were excluded by skin scrapings and fungal culture, respectively. Lesions (erythema, lichenification, papules, pustules and excoriations) were graded with a quantitative 4‐point scale (maximal total score 15). Extent of lesion was also estimated. Pruritus was graded on a 4‐point scale. Scores were given at the time of inclusion and at day 30 after treatment with doxycycline 10 mg/kg once daily. Twelve dogs (10 males and two females) representing seven breeds were included. Good improvement of both lesional (9.4 before treatment and 2.3 after treatment) and extent scores (43% before treatment and 8% after treatment) was achieved. Pruritus was also markedly improved from 2.08 before treatment to 0.42 after treatment. One dog was not significantly improved after 1 month. Results of this trial suggest that doxycyline is useful for reducing the severity of localized skin lesions of canine acne. Funding: Self‐funded.</div>
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P‐16 Treatment of Malassezia otitis in dogs: a comparative field trial

P‐16 Treatment of Malassezia otitis in dogs: a comparative field trial

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