P‐48 Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded, randomized, controlled trial
Identifieur interne : 000055 ( Istex/Corpus ); précédent : 000054; suivant : 000056P‐48 Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded, randomized, controlled trial
Auteurs : E. Bensignor ; T. OlivrySource :
- Veterinary Dermatology [ 0959-4493 ] ; 2004-08.
Abstract
The purpose of this study was to determine whether tacrolimus ointment (Protopic) decreased the severity of localized lesions of canine atopic dermatitis (AD). Twenty dogs with AD were enrolled if they exhibited skin lesions localized to both front metacarpi. Each foot was randomized to be treated either with 0.1% tacrolimus or placebo (vaseline) ointment twice daily for 6 weeks. The nature of treatment for each foot lesion was concealed from the clinician. Before, and every 2 weeks during the study, erythema, lichenification, oozing and excoriations each were graded on a 10‐point scale (maximal total score: 40). The primary outcome measures consisted of the percentage reduction from baseline of lesional scores, and the number of subjects whose scores had decreased by 50% or greater by the end of the study. Intent‐to‐treat analyses were used. At the beginning of the study, lesional scores were not significantly different between treatment groups. After 6 weeks, the percentage reduction from baseline scores was higher for tacrolimus‐treated sites [median: 63% (95% CI: 39–67)] than for placebo‐treated feet [3% (‐2‐13)] (paired t‐test; P < 0.0001). When tacrolimus was applied, lesions decreased by 50% or greater in 15 dogs (75%), while this benchmark was not reached for any placebo‐treated feet (Fisher's exact test; P < 0.0001). Adverse drug events consisted of minor irritation in some dogs treated with tacrolimus. Results of this randomized, controlled trial suggest that the daily application of 0.1% tacrolimus ointment is useful for reducing the severity of localized skin lesions of canine AD. Funding: Self‐funded.
Url:
DOI: 10.1111/j.1365-3164.2004.00414_48.x
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ISTEX:0136539570FA13EA6916DEAC9E4DEDCDC393D221Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">P‐48 Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded, randomized, controlled trial</title><author><name sortKey="Bensignor, E" sort="Bensignor, E" uniqKey="Bensignor E" first="E." last="Bensignor">E. Bensignor</name><affiliation><mods:affiliation>Veterinary Dermatology Referral Service, Paris, France; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Olivry, T" sort="Olivry, T" uniqKey="Olivry T" first="T." last="Olivry">T. Olivry</name><affiliation><mods:affiliation>Veterinary Dermatology Referral Service, Paris, France; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0136539570FA13EA6916DEAC9E4DEDCDC393D221</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1111/j.1365-3164.2004.00414_48.x</idno><idno type="url">https://api.istex.fr/document/0136539570FA13EA6916DEAC9E4DEDCDC393D221/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000055</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000055</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">P‐48
Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded, randomized, controlled trial</title><author><name sortKey="Bensignor, E" sort="Bensignor, E" uniqKey="Bensignor E" first="E." last="Bensignor">E. Bensignor</name><affiliation><mods:affiliation>Veterinary Dermatology Referral Service, Paris, France; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA</mods:affiliation></affiliation></author><author><name sortKey="Olivry, T" sort="Olivry, T" uniqKey="Olivry T" first="T." last="Olivry">T. Olivry</name><affiliation><mods:affiliation>Veterinary Dermatology Referral Service, Paris, France; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Veterinary Dermatology</title><title level="j" type="alt">VETERINARY DERMATOLOGY</title><idno type="ISSN">0959-4493</idno><idno type="eISSN">1365-3164</idno><imprint><biblScope unit="vol">15</biblScope><biblScope unit="page" from="56">56</biblScope><biblScope unit="page" to="56">56</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2004-08">2004-08</date></imprint><idno type="ISSN">0959-4493</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0959-4493</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this study was to determine whether tacrolimus ointment (Protopic) decreased the severity of localized lesions of canine atopic dermatitis (AD). Twenty dogs with AD were enrolled if they exhibited skin lesions localized to both front metacarpi. Each foot was randomized to be treated either with 0.1% tacrolimus or placebo (vaseline) ointment twice daily for 6 weeks. The nature of treatment for each foot lesion was concealed from the clinician. Before, and every 2 weeks during the study, erythema, lichenification, oozing and excoriations each were graded on a 10‐point scale (maximal total score: 40). The primary outcome measures consisted of the percentage reduction from baseline of lesional scores, and the number of subjects whose scores had decreased by 50% or greater by the end of the study. Intent‐to‐treat analyses were used. At the beginning of the study, lesional scores were not significantly different between treatment groups. After 6 weeks, the percentage reduction from baseline scores was higher for tacrolimus‐treated sites [median: 63% (95% CI: 39–67)] than for placebo‐treated feet [3% (‐2‐13)] (paired t‐test; P < 0.0001). When tacrolimus was applied, lesions decreased by 50% or greater in 15 dogs (75%), while this benchmark was not reached for any placebo‐treated feet (Fisher's exact test; P < 0.0001). Adverse drug events consisted of minor irritation in some dogs treated with tacrolimus. Results of this randomized, controlled trial suggest that the daily application of 0.1% tacrolimus ointment is useful for reducing the severity of localized skin lesions of canine AD. 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Bensignor</name><affiliations><json:string>Veterinary Dermatology Referral Service, Paris, France; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA</json:string></affiliations></json:item><json:item><name>T. Olivry</name><affiliations><json:string>Veterinary Dermatology Referral Service, Paris, France; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA</json:string></affiliations></json:item></author><articleId><json:string>VDE414_48_48</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>abstract</json:string></originalGenre><abstract>The purpose of this study was to determine whether tacrolimus ointment (Protopic) decreased the severity of localized lesions of canine atopic dermatitis (AD). Twenty dogs with AD were enrolled if they exhibited skin lesions localized to both front metacarpi. Each foot was randomized to be treated either with 0.1% tacrolimus or placebo (vaseline) ointment twice daily for 6 weeks. The nature of treatment for each foot lesion was concealed from the clinician. Before, and every 2 weeks during the study, erythema, lichenification, oozing and excoriations each were graded on a 10‐point scale (maximal total score: 40). The primary outcome measures consisted of the percentage reduction from baseline of lesional scores, and the number of subjects whose scores had decreased by 50% or greater by the end of the study. Intent‐to‐treat analyses were used. At the beginning of the study, lesional scores were not significantly different between treatment groups. After 6 weeks, the percentage reduction from baseline scores was higher for tacrolimus‐treated sites [median: 63% (95% CI: 39–67)] than for placebo‐treated feet [3% (‐2‐13)] (paired t‐test; P > 0.0001). When tacrolimus was applied, lesions decreased by 50% or greater in 15 dogs (75%), while this benchmark was not reached for any placebo‐treated feet (Fisher's exact test; P > 0.0001). Adverse drug events consisted of minor irritation in some dogs treated with tacrolimus. Results of this randomized, controlled trial suggest that the daily application of 0.1% tacrolimus ointment is useful for reducing the severity of localized skin lesions of canine AD. Funding: Self‐funded.</abstract><qualityIndicators><score>8.428</score><pdfVersion>1.4</pdfVersion><pdfPageSize>595 x 842 pts (A4)</pdfPageSize><refBibsNative>false</refBibsNative><abstractCharCount>1641</abstractCharCount><pdfWordCount>20170</pdfWordCount><pdfCharCount>133096</pdfCharCount><pdfPageCount>29</pdfPageCount><abstractWordCount>244</abstractWordCount></qualityIndicators><title>P‐48 Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded, randomized, controlled trial</title><genre><json:string>abstract</json:string></genre><host><title>Veterinary Dermatology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1365-3164</json:string></doi><issn><json:string>0959-4493</json:string></issn><eissn><json:string>1365-3164</json:string></eissn><publisherId><json:string>VDE</json:string></publisherId><volume>15</volume><pages><first>56</first><last>56</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>veterinary sciences</json:string><json:string>dermatology</json:string></wos><scienceMetrix><json:string>applied sciences</json:string><json:string>agriculture, fisheries & forestry</json:string><json:string>veterinary sciences</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>2004</publicationDate><copyrightDate>2004</copyrightDate><doi><json:string>10.1111/j.1365-3164.2004.00414_48.x</json:string></doi><id>0136539570FA13EA6916DEAC9E4DEDCDC393D221</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/0136539570FA13EA6916DEAC9E4DEDCDC393D221/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/0136539570FA13EA6916DEAC9E4DEDCDC393D221/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/0136539570FA13EA6916DEAC9E4DEDCDC393D221/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">P‐48
Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded, randomized, controlled trial</title></titleStmt><publicationStmt><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2004-08"></date></publicationStmt><notesStmt><note type="content-type" subtype="abstract" source="abstract" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-HPN7T1Q2-R">abstract</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="abstract"><analytic><title level="a" type="main">P‐48
Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded, randomized, controlled trial</title><title level="a" type="short">Poster Abstracts</title><author xml:id="author-0000"><persName><forename type="first">E.</forename><surname>Bensignor</surname></persName><affiliation>Veterinary Dermatology Referral Service, Paris, France; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">T.</forename><surname>Olivry</surname></persName><affiliation>Veterinary Dermatology Referral Service, Paris, France; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA<address><country key="US"></country></address></affiliation></author><idno type="istex">0136539570FA13EA6916DEAC9E4DEDCDC393D221</idno><idno type="DOI">10.1111/j.1365-3164.2004.00414_48.x</idno><idno type="unit">VDE414_48_48</idno><idno type="toTypesetVersion">file:VDE.VDE414_48_48.pdf</idno></analytic><monogr><title level="j" type="main">Veterinary Dermatology</title><title level="j" type="alt">VETERINARY DERMATOLOGY</title><idno type="pISSN">0959-4493</idno><idno type="eISSN">1365-3164</idno><idno type="book-DOI">10.1111/(ISSN)1365-3164</idno><idno type="book-part-DOI">10.1111/vde.2004.15.issue-s1</idno><idno type="product">VDE</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">15</biblScope><biblScope unit="page" from="56">56</biblScope><biblScope unit="page" to="56">56</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2004-08"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p>The purpose of this study was to determine whether tacrolimus ointment (Protopic) decreased the severity of localized lesions of canine atopic dermatitis (AD). Twenty dogs with AD were enrolled if they exhibited skin lesions localized to both front metacarpi. Each foot was randomized to be treated either with 0.1% tacrolimus or placebo (vaseline) ointment twice daily for 6 weeks. The nature of treatment for each foot lesion was concealed from the clinician. Before, and every 2 weeks during the study, erythema, lichenification, oozing and excoriations each were graded on a 10‐point scale (maximal total score: 40). The primary outcome measures consisted of the percentage reduction from baseline of lesional scores, and the number of subjects whose scores had decreased by 50% or greater by the end of the study. Intent‐to‐treat analyses were used. At the beginning of the study, lesional scores were not significantly different between treatment groups. After 6 weeks, the percentage reduction from baseline scores was higher for tacrolimus‐treated sites [median: 63% (95% CI: 39–67)] than for placebo‐treated feet [3% (‐2‐13)] (paired <hi rend="italic">t</hi>‐test; <hi rend="italic">P </hi>< 0.0001). When tacrolimus was applied, lesions decreased by 50% or greater in 15 dogs (75%), while this benchmark was not reached for any placebo‐treated feet (Fisher's exact test; <hi rend="italic">P</hi> < 0.0001). Adverse drug events consisted of minor irritation in some dogs treated with tacrolimus. Results of this randomized, controlled trial suggest that the daily application of 0.1% tacrolimus ointment is useful for reducing the severity of localized skin lesions of canine AD.</p><p>
<hi rend="italic">Funding: Self‐funded.</hi>
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Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded, randomized, controlled trial</title><title type="short">Poster Abstracts</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#aff-1-1"><personName><givenNames>E.</givenNames><familyName>Bensignor</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#aff-1-1"><personName><givenNames>T.</givenNames><familyName>Olivry</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="US"><unparsedAffiliation>Veterinary Dermatology Referral Service, Paris, France; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p>The purpose of this study was to determine whether tacrolimus ointment (Protopic) decreased the severity of localized lesions of canine atopic dermatitis (AD). Twenty dogs with AD were enrolled if they exhibited skin lesions localized to both front metacarpi. Each foot was randomized to be treated either with 0.1% tacrolimus or placebo (vaseline) ointment twice daily for 6 weeks. The nature of treatment for each foot lesion was concealed from the clinician. Before, and every 2 weeks during the study, erythema, lichenification, oozing and excoriations each were graded on a 10‐point scale (maximal total score: 40). The primary outcome measures consisted of the percentage reduction from baseline of lesional scores, and the number of subjects whose scores had decreased by 50% or greater by the end of the study. Intent‐to‐treat analyses were used. At the beginning of the study, lesional scores were not significantly different between treatment groups. After 6 weeks, the percentage reduction from baseline scores was higher for tacrolimus‐treated sites [median: 63% (95% CI: 39–67)] than for placebo‐treated feet [3% (‐2‐13)] (paired <i>t</i>‐test; <i>P </i>< 0.0001). When tacrolimus was applied, lesions decreased by 50% or greater in 15 dogs (75%), while this benchmark was not reached for any placebo‐treated feet (Fisher's exact test; <i>P</i> < 0.0001). Adverse drug events consisted of minor irritation in some dogs treated with tacrolimus. Results of this randomized, controlled trial suggest that the daily application of 0.1% tacrolimus ointment is useful for reducing the severity of localized skin lesions of canine AD.</p><p> <i>Funding: Self‐funded.</i> </p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>P‐48 Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded, randomized, controlled trial</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Poster Abstracts</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>P‐48
Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded, randomized, controlled trial</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Bensignor</namePart><affiliation>Veterinary Dermatology Referral Service, Paris, France; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Olivry</namePart><affiliation>Veterinary Dermatology Referral Service, Paris, France; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="abstract" displayLabel="abstract"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2004-08</dateIssued><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The purpose of this study was to determine whether tacrolimus ointment (Protopic) decreased the severity of localized lesions of canine atopic dermatitis (AD). Twenty dogs with AD were enrolled if they exhibited skin lesions localized to both front metacarpi. Each foot was randomized to be treated either with 0.1% tacrolimus or placebo (vaseline) ointment twice daily for 6 weeks. The nature of treatment for each foot lesion was concealed from the clinician. Before, and every 2 weeks during the study, erythema, lichenification, oozing and excoriations each were graded on a 10‐point scale (maximal total score: 40). The primary outcome measures consisted of the percentage reduction from baseline of lesional scores, and the number of subjects whose scores had decreased by 50% or greater by the end of the study. Intent‐to‐treat analyses were used. At the beginning of the study, lesional scores were not significantly different between treatment groups. After 6 weeks, the percentage reduction from baseline scores was higher for tacrolimus‐treated sites [median: 63% (95% CI: 39–67)] than for placebo‐treated feet [3% (‐2‐13)] (paired t‐test; P < 0.0001). When tacrolimus was applied, lesions decreased by 50% or greater in 15 dogs (75%), while this benchmark was not reached for any placebo‐treated feet (Fisher's exact test; P < 0.0001). Adverse drug events consisted of minor irritation in some dogs treated with tacrolimus. Results of this randomized, controlled trial suggest that the daily application of 0.1% tacrolimus ointment is useful for reducing the severity of localized skin lesions of canine AD. Funding: Self‐funded.</abstract><relatedItem type="host"><titleInfo><title>Veterinary Dermatology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0959-4493</identifier><identifier type="eISSN">1365-3164</identifier><identifier type="DOI">10.1111/(ISSN)1365-3164</identifier><identifier type="PublisherID">VDE</identifier><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="supplement"><caption>Suppl. no.</caption><number>s1</number></detail><extent unit="pages"><start>56</start><end>56</end></extent></part></relatedItem><identifier type="istex">0136539570FA13EA6916DEAC9E4DEDCDC393D221</identifier><identifier type="DOI">10.1111/j.1365-3164.2004.00414_48.x</identifier><identifier type="ArticleID">VDE414_48_48</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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