Antiplasmodial Phenolic Compounds from Piptadenia pervillei
Identifieur interne : 001A43 ( Main/Exploration ); précédent : 001A42; suivant : 001A44Antiplasmodial Phenolic Compounds from Piptadenia pervillei
Auteurs : Voahangy Ramanandraibe [Madagascar] ; Philippe Grellier [France] ; Marie-Thérèse Martin [France] ; Alexandre Deville [France] ; Roger Joyeau [France] ; David Ramanitrahasimbola [Madagascar] ; Elisabeth Mouray [France] ; Philippe Rasoanaivo [Madagascar] ; Lengo Mambu [France]Source :
- Planta medica [ 0032-0943 ] ; 2008.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Antinéoplasiques d'origine végétale, Antipaludiques.
- Pascal (Inist)
- Wicri :
- topic : Plante médicinale.
English descriptors
- KwdEn :
- Animals, Antimalarial, Antimalarials (chemistry), Antimalarials (pharmacology), Antineoplastic Agents, Phytogenic (chemistry), Antineoplastic Agents, Phytogenic (pharmacology), Cell Line, Fabaceae (chemistry), Humans, Leguminosae, Medicinal plant, Molecular Structure, Parasiticide, Pharmacognosy, Phenols (chemistry), Plant origin, Plasmodium falciparum (drug effects).
- MESH :
- chemical , chemistry : Antimalarials, Antineoplastic Agents, Phytogenic, Phenols.
- chemical , pharmacology : Antimalarials, Antineoplastic Agents, Phytogenic.
- chemistry : Fabaceae.
- drug effects : Plasmodium falciparum.
- Animals, Cell Line, Humans, Molecular Structure.
Abstract
Piptadenia pervillei Vatke (Fabaceae) was selected from a screening programme devoted to the search of naturally-occuring antimalarial compounds from plants of Madagascar. Bioassay-guided fractionation of the ethyl acetate extract of the leaves led to the isolation of four phenolic compounds, (+)-catechin (1), (+)-catechin 5-gallate (2), (+)-catechin 3-gallate (3) and ethyl gallate (4). Structures were determined by NMR and mass spectroscopy. Compounds 2 and 3 displayed the highest in vitro activity against the chloroquine-resistant strain FcBl of Plasmodium falciparum with ICso values of 1.2 pM and 1.0 pM, respectively, and no significant cytotoxicity against the human embryonic lung cells MRC-5 was measured (IC50 values >75μM). Five analogues (5-9) of (+)-catechin 5-gallate (2) were synthesized and evaluated for their antiplasmodial activity.
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Affiliations:
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Le document en format XML
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<author><name sortKey="Ramanitrahasimbola, David" sort="Ramanitrahasimbola, David" uniqKey="Ramanitrahasimbola D" first="David" last="Ramanitrahasimbola">David Ramanitrahasimbola</name>
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<term>Antimalarials (pharmacology)</term>
<term>Antineoplastic Agents, Phytogenic (chemistry)</term>
<term>Antineoplastic Agents, Phytogenic (pharmacology)</term>
<term>Cell Line</term>
<term>Fabaceae (chemistry)</term>
<term>Humans</term>
<term>Leguminosae</term>
<term>Medicinal plant</term>
<term>Molecular Structure</term>
<term>Parasiticide</term>
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<term>Antipaludiques ()</term>
<term>Antipaludiques (pharmacologie)</term>
<term>Fabaceae ()</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
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<term>Plasmodium falciparum ()</term>
<term>Structure moléculaire</term>
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<term>Antipaludiques</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">Piptadenia pervillei Vatke (Fabaceae) was selected from a screening programme devoted to the search of naturally-occuring antimalarial compounds from plants of Madagascar. Bioassay-guided fractionation of the ethyl acetate extract of the leaves led to the isolation of four phenolic compounds, (+)-catechin (1), (+)-catechin 5-gallate (2), (+)-catechin 3-gallate (3) and ethyl gallate (4). Structures were determined by NMR and mass spectroscopy. Compounds 2 and 3 displayed the highest in vitro activity against the chloroquine-resistant strain FcBl of Plasmodium falciparum with IC<sub>so</sub>
values of 1.2 pM and 1.0 pM, respectively, and no significant cytotoxicity against the human embryonic lung cells MRC-5 was measured (IC<sub>50</sub>
values >75μM). Five analogues (5-9) of (+)-catechin 5-gallate (2) were synthesized and evaluated for their antiplasmodial activity.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Madagascar</li>
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<region><li>Île-de-France</li>
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<tree><country name="Madagascar"><noRegion><name sortKey="Ramanandraibe, Voahangy" sort="Ramanandraibe, Voahangy" uniqKey="Ramanandraibe V" first="Voahangy" last="Ramanandraibe">Voahangy Ramanandraibe</name>
</noRegion>
<name sortKey="Ramanitrahasimbola, David" sort="Ramanitrahasimbola, David" uniqKey="Ramanitrahasimbola D" first="David" last="Ramanitrahasimbola">David Ramanitrahasimbola</name>
<name sortKey="Rasoanaivo, Philippe" sort="Rasoanaivo, Philippe" uniqKey="Rasoanaivo P" first="Philippe" last="Rasoanaivo">Philippe Rasoanaivo</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Grellier, Philippe" sort="Grellier, Philippe" uniqKey="Grellier P" first="Philippe" last="Grellier">Philippe Grellier</name>
</region>
<name sortKey="Deville, Alexandre" sort="Deville, Alexandre" uniqKey="Deville A" first="Alexandre" last="Deville">Alexandre Deville</name>
<name sortKey="Joyeau, Roger" sort="Joyeau, Roger" uniqKey="Joyeau R" first="Roger" last="Joyeau">Roger Joyeau</name>
<name sortKey="Mambu, Lengo" sort="Mambu, Lengo" uniqKey="Mambu L" first="Lengo" last="Mambu">Lengo Mambu</name>
<name sortKey="Martin, Marie Therese" sort="Martin, Marie Therese" uniqKey="Martin M" first="Marie-Thérèse" last="Martin">Marie-Thérèse Martin</name>
<name sortKey="Mouray, Elisabeth" sort="Mouray, Elisabeth" uniqKey="Mouray E" first="Elisabeth" last="Mouray">Elisabeth Mouray</name>
</country>
</tree>
</affiliations>
</record>
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