Antiplasmodial Phenolic Compounds from Piptadenia pervillei
Identifieur interne : 000031 ( PascalFrancis/Corpus ); précédent : 000030; suivant : 000032Antiplasmodial Phenolic Compounds from Piptadenia pervillei
Auteurs : Voahangy Ramanandraibe ; Philippe Grellier ; Marie-Thérèse Martin ; Alexandre Deville ; Roger Joyeau ; David Ramanitrahasimbola ; Elisabeth Mouray ; Philippe Rasoanaivo ; Lengo MambuSource :
- Planta medica [ 0032-0943 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Piptadenia pervillei Vatke (Fabaceae) was selected from a screening programme devoted to the search of naturally-occuring antimalarial compounds from plants of Madagascar. Bioassay-guided fractionation of the ethyl acetate extract of the leaves led to the isolation of four phenolic compounds, (+)-catechin (1), (+)-catechin 5-gallate (2), (+)-catechin 3-gallate (3) and ethyl gallate (4). Structures were determined by NMR and mass spectroscopy. Compounds 2 and 3 displayed the highest in vitro activity against the chloroquine-resistant strain FcBl of Plasmodium falciparum with ICso values of 1.2 pM and 1.0 pM, respectively, and no significant cytotoxicity against the human embryonic lung cells MRC-5 was measured (IC50 values >75μM). Five analogues (5-9) of (+)-catechin 5-gallate (2) were synthesized and evaluated for their antiplasmodial activity.
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Format Inist (serveur)
NO : | PASCAL 08-0207828 INIST |
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ET : | Antiplasmodial Phenolic Compounds from Piptadenia pervillei |
AU : | RAMANANDRAIBE (Voahangy); GRELLIER (Philippe); MARTIN (Marie-Thérèse); DEVILLE (Alexandre); JOYEAU (Roger); RAMANITRAHASIMBOLA (David); MOURAY (Elisabeth); RASOANAIVO (Philippe); MAMBU (Lengo) |
AF : | Laboratoire de Bio-thérapeutique, Institut Malgache de Recherches Appliquées/Antananarivo/Madagascar (1 aut., 6 aut., 8 aut.); USM 0504 Biologie Fonctionnelle des Protozoaires, Département Régulations, Développement et Diversité Moléculaire, Muséum National d'Histoire Naturelle/Paris/France (2 aut., 7 aut.); Institut de Chimie des Substances Naturelles, CNRS/Gif-sur-Yvette/France (3 aut.); USM 0502-UMR 5154 CNRS Chimie et Biochimie des Substances Naturelles, Département Régulations, Développement et Diversité Moléculaire, Muséum National d'Histoire Naturelle/Paris/France (4 aut., 5 aut., 9 aut.) |
DT : | Publication en série; Correspondance, lettre; Niveau analytique |
SO : | Planta medica; ISSN 0032-0943; Coden PLMEAA; Allemagne; Da. 2008; Vol. 74; No. 4; Pp. 417-421; Bibl. 23 ref. |
LA : | Anglais |
EA : | Piptadenia pervillei Vatke (Fabaceae) was selected from a screening programme devoted to the search of naturally-occuring antimalarial compounds from plants of Madagascar. Bioassay-guided fractionation of the ethyl acetate extract of the leaves led to the isolation of four phenolic compounds, (+)-catechin (1), (+)-catechin 5-gallate (2), (+)-catechin 3-gallate (3) and ethyl gallate (4). Structures were determined by NMR and mass spectroscopy. Compounds 2 and 3 displayed the highest in vitro activity against the chloroquine-resistant strain FcBl of Plasmodium falciparum with ICso values of 1.2 pM and 1.0 pM, respectively, and no significant cytotoxicity against the human embryonic lung cells MRC-5 was measured (IC50 values >75μM). Five analogues (5-9) of (+)-catechin 5-gallate (2) were synthesized and evaluated for their antiplasmodial activity. |
CC : | 002B02A04 |
FD : | Antipaludique; Leguminosae; Pharmacognosie; Plante médicinale; Origine végétale; Antiparasitaire; Catéchine gallate |
FG : | Dicotyledones; Angiospermae; Spermatophyta |
ED : | Antimalarial; Leguminosae; Pharmacognosy; Medicinal plant; Plant origin; Parasiticide |
EG : | Dicotyledones; Angiospermae; Spermatophyta |
SD : | Antipalúdico; Leguminosae; Farmacognosia; Planta medicinal; Origen vegetal; Antiparasitario |
LO : | INIST-9624.354000183350430100 |
ID : | 08-0207828 |
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<front><div type="abstract" xml:lang="en">Piptadenia pervillei Vatke (Fabaceae) was selected from a screening programme devoted to the search of naturally-occuring antimalarial compounds from plants of Madagascar. Bioassay-guided fractionation of the ethyl acetate extract of the leaves led to the isolation of four phenolic compounds, (+)-catechin (1), (+)-catechin 5-gallate (2), (+)-catechin 3-gallate (3) and ethyl gallate (4). Structures were determined by NMR and mass spectroscopy. Compounds 2 and 3 displayed the highest in vitro activity against the chloroquine-resistant strain FcBl of Plasmodium falciparum with IC<sub>so</sub>
values of 1.2 pM and 1.0 pM, respectively, and no significant cytotoxicity against the human embryonic lung cells MRC-5 was measured (IC<sub>50</sub>
values >75μM). Five analogues (5-9) of (+)-catechin 5-gallate (2) were synthesized and evaluated for their antiplasmodial activity.</div>
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<s5>23</s5>
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<fC03 i1="06" i2="X" l="FRE"><s0>Antiparasitaire</s0>
<s5>24</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Parasiticide</s0>
<s5>24</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Antiparasitario</s0>
<s5>24</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Catéchine gallate</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>133</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 08-0207828 INIST</NO>
<ET>Antiplasmodial Phenolic Compounds from Piptadenia pervillei</ET>
<AU>RAMANANDRAIBE (Voahangy); GRELLIER (Philippe); MARTIN (Marie-Thérèse); DEVILLE (Alexandre); JOYEAU (Roger); RAMANITRAHASIMBOLA (David); MOURAY (Elisabeth); RASOANAIVO (Philippe); MAMBU (Lengo)</AU>
<AF>Laboratoire de Bio-thérapeutique, Institut Malgache de Recherches Appliquées/Antananarivo/Madagascar (1 aut., 6 aut., 8 aut.); USM 0504 Biologie Fonctionnelle des Protozoaires, Département Régulations, Développement et Diversité Moléculaire, Muséum National d'Histoire Naturelle/Paris/France (2 aut., 7 aut.); Institut de Chimie des Substances Naturelles, CNRS/Gif-sur-Yvette/France (3 aut.); USM 0502-UMR 5154 CNRS Chimie et Biochimie des Substances Naturelles, Département Régulations, Développement et Diversité Moléculaire, Muséum National d'Histoire Naturelle/Paris/France (4 aut., 5 aut., 9 aut.)</AF>
<DT>Publication en série; Correspondance, lettre; Niveau analytique</DT>
<SO>Planta medica; ISSN 0032-0943; Coden PLMEAA; Allemagne; Da. 2008; Vol. 74; No. 4; Pp. 417-421; Bibl. 23 ref.</SO>
<LA>Anglais</LA>
<EA>Piptadenia pervillei Vatke (Fabaceae) was selected from a screening programme devoted to the search of naturally-occuring antimalarial compounds from plants of Madagascar. Bioassay-guided fractionation of the ethyl acetate extract of the leaves led to the isolation of four phenolic compounds, (+)-catechin (1), (+)-catechin 5-gallate (2), (+)-catechin 3-gallate (3) and ethyl gallate (4). Structures were determined by NMR and mass spectroscopy. Compounds 2 and 3 displayed the highest in vitro activity against the chloroquine-resistant strain FcBl of Plasmodium falciparum with IC<sub>so</sub>
values of 1.2 pM and 1.0 pM, respectively, and no significant cytotoxicity against the human embryonic lung cells MRC-5 was measured (IC<sub>50</sub>
values >75μM). Five analogues (5-9) of (+)-catechin 5-gallate (2) were synthesized and evaluated for their antiplasmodial activity.</EA>
<CC>002B02A04</CC>
<FD>Antipaludique; Leguminosae; Pharmacognosie; Plante médicinale; Origine végétale; Antiparasitaire; Catéchine gallate</FD>
<FG>Dicotyledones; Angiospermae; Spermatophyta</FG>
<ED>Antimalarial; Leguminosae; Pharmacognosy; Medicinal plant; Plant origin; Parasiticide</ED>
<EG>Dicotyledones; Angiospermae; Spermatophyta</EG>
<SD>Antipalúdico; Leguminosae; Farmacognosia; Planta medicinal; Origen vegetal; Antiparasitario</SD>
<LO>INIST-9624.354000183350430100</LO>
<ID>08-0207828</ID>
</server>
</inist>
</record>
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